University Hospital, Tours

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This study looks at children aged 3 to 10 who need surgery for a spine problem called hemivertebra. The goal is to see how well the surgery corrects the spine curve and what complications might happen, like nerve issues or the curve coming back. Researchers will follow the childr…

This Phase 3 trial tests whether adjusting the dose of bevacizumab based on each patient's drug levels can better control metastatic colorectal cancer. About 244 people will receive either standard or personalized dosing alongside chemotherapy. The main goal is to see if personal…

This study looks at whether a dedicated, step-by-step care plan can help people who have a brain bleed (intracerebral hemorrhage). About 600 adults admitted to the University Hospital of Tours will be followed to see if the new protocol reduces deaths and long-term disability com…

This study tests whether a structured diet and exercise program can help adults with cystic fibrosis increase their lean muscle mass. Participants must be 18 or older, have cystic fibrosis, and have been taking the drug Trikafta for at least 6 months. The program combines dietary…

This study tests whether a treatment plan that uses water pills (diuretics) can better control blood pressure in people with moderate to severe chronic kidney disease whose blood pressure remains high despite standard medications. About 720 adults will be assigned to either the d…

This study is testing a new memory assessment tool called NEM (New evaluation of Episodic Memory) to see if it can better diagnose Alzheimer's disease in its early stages. Researchers will enroll 150 adults aged 50 and older with mild memory problems (amnesic MCI). The new test f…

This study aims to find out if proteins and fats in tears can be used to diagnose Alzheimer's disease. Researchers will collect tear samples from 90 participants (people with Alzheimer's and healthy volunteers) and compare the levels of certain biomarkers. If successful, this cou…

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study tests whether lying face down (prone position) while awake can help people with severe pneumonia avoid needing a breathing tube. Researchers will study 1078 adults in intensive care who need high-flow oxygen. The goal is to see if this simple position change reduces th…

This study tests whether serving food as easy-to-grip bites (finger food) helps elderly residents in care homes eat more, gain weight, and enjoy meals more. Thirty residents over 75 with weight loss or muscle loss will be randomly assigned to finger food or usual meals. The main …

This study tests a type of talk therapy called dissociation-focused cognitive behavioral therapy (DF-CBT) for people with dissociative disorders, such as depersonalization or dissociative identity disorder. The goal is to see if it reduces symptoms like feeling detached from your…

This study looks at two common ways to start labor in pregnant women whose cervix hasn't softened enough after 24 hours of preparation. One method uses the hormone oxytocin, and the other uses a different hormone called prostaglandins. The goal is to see which approach leads to f…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests whether using hypnosis during a screening colonoscopy helps people feel less anxious and in less pain, and whether it helps doctors complete the exam more fully. About 600 adults in France will be randomly assigned to receive either standard care or hypnosis duri…

This study tests whether giving a water pill (furosemide) and extra fluids during laser kidney stone surgery helps clear out tiny leftover fragments. About 374 adults who need this surgery will be randomly assigned to receive either the water pill plus fluids or standard care. Th…

This study tests a new high-tech device that uses eye-tracking to help patients in the intensive care unit (ICU) who are on breathing machines communicate with their caregivers. Many of these patients are awake but cannot speak due to a tube in their throat, which can be frustrat…

This study is testing a new, non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) to measure tiny brain movements. Researchers will compare these measurements in 300 people with mild versus major cognitive disorders. The goal is to see if brain pulse patterns…

This study looks at specific immune cells (iNKT cells and monocytes) in people with lupus to see how certain receptors on these cells change when the disease is active versus stable. Researchers will collect extra blood samples from 50 lupus patients during routine visits. The go…

This study is gathering information from 10,000 people who have had a spontaneous brain hemorrhage. Researchers will collect medical history, brain scans, and blood samples to better understand the condition and find clues that help predict recovery. The goal is to improve how do…

This study collects nasal cells from 100 adults during planned nose surgery. The cells are grown in the lab to create a realistic model for testing how well drugs are delivered and work. The goal is to build a cell collection that helps improve treatments for respiratory infectio…

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This study looks at bone marrow cells from children with acute leukemia and compares them to cells from children without blood diseases. The goal is to understand why some leukemias relapse or resist treatment. Researchers will measure how these cells use energy and handle stress…

This study looks at how quickly the kidneys clear morphine in sickle cell patients having a painful crisis. Researchers will measure kidney function and morphine levels in 100 intensive care patients to see if higher doses are needed for effective pain relief. The goal is to pers…

This study looks at whether patients with severe breathing problems in the ICU should be allowed to eat or drink before they need a breathing tube. Currently, patients are often kept fasting to prevent food from entering the lungs, but this can cause discomfort and malnutrition. …

This study looks at how genes and body chemistry are linked in adults with phenylketonuria (PKU) who were treated early in life. Researchers will analyze blood and saliva samples from 149 participants to find patterns that may explain differences in health and thinking skills. No…

This study looks at how mucus from the airways of people with bronchiectasis affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults with stable bronchiectasis and test how well the antibodies can reach and bind to bacteria in the lab. The…

This study is testing whether a blood-based model can predict how well rheumatoid arthritis patients will respond to a lower dose of the drug rituximab. Researchers will enroll 30 adults who already respond well to standard-dose rituximab and switch them to a single 1000 mg infus…