Mucus may block inhaled antibodies in lung disease
NCT ID NCT06670937
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how mucus from the airways of people with bronchiectasis affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults with stable bronchiectasis and test how well the antibodies can reach and bind to bacteria in the lab. The goal is to understand barriers to this therapy and help design better inhaled treatments for chronic lung infections.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Clinical diagnosis of NCFB * Computed tomography (CT) evidence of bilateral bronchiectasis * Consent for research use of data and material * Ability to provide an induced sputum sample * Stable clinical status over the last 4 weeks Exclusion Criteria: * Pulmonary disease other than NCFB (except asthma) * Diagnosis of cystic fibrosis * Diagnosis of primary ciliary dyskinesia * Requirement for oxygen therapy at rest * Diagnosis of IgG deficiency (total serum IgG \< 5.4 g/l) * Treatment with a CFTR modulator drug in the last 6 months * Unilateral bronchectasis * CT evidence of interstitial lung disease with traction bronchectasis * Refusal of the patient * Acute exacerbation of NFCB in the last 4 weeks * No sputum production * Current treatment with systemic antibiotics (other than low dose azithromycin) * Pregnancy or breastfeeding * Subject under legal protection (e.g., guardianship, tutorship). * Inability to produce a sputum sample
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHRU de Tours
Tours, France, 37044, France
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Other studies related to the condition(s) this trial covers.
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