University Hospital, Tours

This study tests whether giving extra oxygen through the nose during the brief pause between stopping a breathing mask and placing a breathing tube can prevent severe drops in oxygen levels. About 500 ICU patients with low oxygen due to lung failure will be randomly assigned to r…

This study tests whether an ultrasound-guided needle biopsy is a safe way to diagnose interstitial lung disease (ILD), a group of conditions that scar the lungs. Fifteen adults who need a tissue sample will first get the ultrasound-guided biopsy under local anesthesia, then have …

This study aims to find specific markers in blood platelets that can help doctors diagnose ALS (Lou Gehrig's disease) more accurately and earlier. Researchers will compare 60 participants—30 with newly diagnosed ALS and 30 with other motor neuron diseases—to see if platelet tests…

This study tests whether wearing compression stockings alone can prevent repeat episodes of erysipelas (a bacterial skin infection) as effectively as taking daily antibiotics plus compression. About 200 adults who have had at least two infections in the same leg will be randomly …

This study tests whether giving the drug propranolol (a beta-blocker) soon after a sexual assault can prevent post-traumatic stress disorder (PTSD). 34 adult women who seek help within 72 hours will take either propranolol or a placebo for 10 days, then a lower dose for another 1…

This study looks at whether playing personalized music through a sound shower in the intensive care unit (ICU) waiting room can lower anxiety for family members. About 224 adults visiting a loved one who is on a breathing machine will take part. Their anxiety levels will be measu…

This study tests whether dexmedetomidine, a sedative, can lower the chance of delirium (sudden confusion) in children who need a breathing machine in the ICU. About 266 children aged 1 month to 17 years will be randomly assigned to receive either dexmedetomidine or the standard d…

This study looks at whether a simple, non-invasive brain ultrasound can help doctors decide which patients with suspected normal pressure hydrocephalus will benefit from a shunt surgery. About 110 adults will have the ultrasound before a standard spinal tap. The research team wil…

This study looks at whether common chemicals like PFAS (found in non-stick pans), BPA (in plastics), and pesticides are linked to obesity in children. Researchers will measure these chemicals in the blood of 80 children aged 6 to 15, comparing those with obesity to those without.…

This study looks at sputum and blood samples from 50 adults with advanced non-small cell lung cancer who are starting immunotherapy. Researchers want to find immune cell changes that could predict which patients will respond well to treatment. The goal is to better understand the…

This study aims to find out how often people with ADHD also have fibromyalgia, and vice versa. Researchers will also look for biological clues in the blood. The study will involve 100 adults who have either ADHD, fibromyalgia, or both. No new treatments are being tested; instead,…

This study looks at a program called Individual Placement and Support (IPS) that helps people with severe mental disorders find regular jobs. It compares IPS to the usual way of getting help from social workers. The goal is to see if IPS is worth the extra cost by measuring how m…

This study looks at how the brain responds to sights and sounds in children and adults with neurodevelopmental disorders (like autism or ADHD) compared to those without. Researchers will measure brain activity using EEG while giving sensory tasks, and also test learning and behav…

This study aims to create a detailed atlas of ultrasound images of the mouth. Researchers will take ultrasound pictures of the inside and outside of the mouth in 100 adult dental patients. The goal is to better understand normal and diseased tissues, which could help dentists dia…