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Compression stockings may let patients skip Long-Term antibiotics for recurring skin infections

NCT ID NCT07549594

Disease control Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether wearing compression stockings alone can prevent repeat episodes of erysipelas (a bacterial skin infection) as well as the usual approach of antibiotics plus stockings. About 200 adults who have had at least two infections in the same leg will be randomly assigned to one year of either compression therapy alone or compression plus daily oral penicillin. If compression alone works, it could spare patients from long-term antibiotic use and its side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Phenoxymethylpenicillin (oral penicillin) and compression stockings
What this could lead to
If compression alone works as well as antibiotics plus compression, patients could avoid long-term antibiotics and their side effects.
What could go wrong
This is a Phase 4 trial with 200 participants, so results may not apply to everyone. Compression alone might not prevent infections as effectively as the combination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female * ≥ 18 years of age * At least 2 episodes of recurrent erysipelas at the same leg within the previous 52 weeks, and no more than five episodes of erysipelas in the same areas of the lower limbs during the year before randomization * The last recurrent erysipelas have to be diagnosed within the previous 3 months * BMI \< 40 kg/m2 (no morbid obesity) * Able to apply the compression alone or with a helper (e.g., nurse, household member) * Affiliated with a social security regimen * Able to consent and written informed consent obtained from the participant * Able to understand the aims of the study and to comply with the requirements of the study * Able to participate and be followed up during the study period Exclusion Criteria: * Any causes of immunosuppression: known HIV+ infection, organ transplantation, bonemarrow transplantation, immunosuppressive regimens for any disease, malignancy or lymphoproliferative disorder * Receiving antibiotic treatment for erysipelas * Received antibiotic prophylaxis for recurrent erysipelas in the year before randomization \_ Received short- or long-term antibiotic therapy for a condition other than erysipelas * Already wore effective compression therapy (worn at least 5 days a week) in the 3 months before randomization * Contraindication to compression therapy (ie heart failure, arterial occlusive disease,including obliterative peripheral arterial disease with a systolic pressure index \< 0.6, advanced diabetic microangiopathy for compression \> 30 mmHg, phlegmasia cerulea dolens, and septic thrombosis) * History of known hypersensitivity to beta-lactamines or contraindications to Phenoxymethylpenicillin (Oracilline) or to any of the other components of the medicine as per its SmPC * Contraindications to the emollient cream in accordance with its SmPC * Diabetic foot and fractures * Woman of childbearing potential not using a highly effective method of contraception\*, or having a desire to conceive, during the whole trial duration. A β-HCG test will be performed in all woman of childbearing potential * Persons covered by articles L1121-5 to L1121-8 of the Code de Santé Publique (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, minors, and persons subject to a legal protection measure: guardianship or trusteeship). * Participation in another interventional research with an investigational drug or medical device. * Mental state rendering the person giving consent incapable of understanding the trial; * Patient being the investigator, or any member of the team or relative of the investigator directly involved in the trial, including assistant doctors, pharmacists, nurses, trial coordinator.

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Conditions

The condition(s) this trial relates to.

erysipelas

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent erysipelas

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    25 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AMIENS

    Amiens, France

  • Bordeaux-D

    Bordeaux, France

  • Bordeaux-I

    Bordeaux, France

  • CRETEIL

    Créteil, France

  • DIJON

    Dijon, France

  • GRENOBLE

    La Tronche, France

  • LE MANS

    Le Mans, France

  • LYON

    Lyon, France

  • La Reunion

    Saint-Pierre, France

  • Lille Ghicl

    Lille, France

  • NANTES-D

    Nantes, France

  • NANTES-I

    Nantes, France

  • ORLEANS

    Orléans, France

  • POITIERS

    Poitiers, France

  • Paris Cognacq-Jay

    Paris, France

  • Paris La Pitie

    Paris, France

  • Paris St Louis-I

    Paris, France

  • Paris St-Antoine-I

    Paris, France

  • REIMS

    Reims, France

  • RENNES-D

    Rennes, France

  • ROUEN

    Rouen, France

  • St-Etienne

    Saint-Etienne, France

  • Strasbourg

    Strasbourg, France

  • TOURS-D

    Chambray-lès-Tours, France

  • TOURS-I

    Tours, France