Could a Parkinson's drug help treat anhedonic depression long-term?
NCT ID NCT05825235
First seen Apr 29, 2026 · Last updated Jun 23, 2026 · Updated 8 times
Summary
This study looked at whether adding pramipexole to usual treatment can help people with anhedonic depression (depression with a loss of interest or pleasure) over six months. 55 adults who had already been in a shorter trial took pramipexole as an add-on. Researchers measured changes in anhedonia and other depression symptoms, as well as side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Region Skåne
Lund, Skåne County, 221 85, Sweden
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pramipexole (a drug used for Parkinson's and restless legs, tested here for depression with loss of interest)
What this could lead to
If it works, this could offer a new long-term treatment option for people with depression who struggle with loss of interest or pleasure.
What could go wrong
This is a small, open-label follow-up study with no placebo group, so results may be less reliable. Side effects of pramipexole can include nausea, dizziness, and impulse control issues.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.