ANHEDONIA

This study tests a two-week smartphone app program designed to help people who have trouble feeling pleasure (anhedonia), along with symptoms of depression, anxiety, and stress. Participants will do three short daily exercises, such as savoring positive moments or practicing grat…

This study tests whether L-DOPA, a drug used for Parkinson's disease, can improve loss of interest and pleasure (anhedonia) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will m…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can improve the ability to feel pleasure (anhedonia) in people with major depression. 85 participants, including healthy volunteers, will take psilocybin in two sessions—once with a drug that blocks th…

This study tests whether estradiol (a form of estrogen) can improve symptoms of depression, psychosis, and loss of pleasure in perimenopausal women aged 44-55. Participants will receive either estradiol or a placebo and undergo brain scans to see how the treatment affects reward-…

This study looks at whether doing a positive mood exercise before exposure therapy can improve treatment for public speaking anxiety. About 94 adults with social anxiety will take part. They will be randomly assigned to either a positive mood treatment or a relaxation treatment b…

This study is testing a smartphone app called Vira, combined with health coaching, to help teens with depression feel more enjoyment in daily activities. The goal is to see if this approach is practical and liked by users, and if it can reduce symptoms like anhedonia (loss of ple…

This study tests a gentle brain stimulation technique called tDCS to see if it can help people with bipolar depression who have lost interest or pleasure in things (anhedonia). Researchers will use brain scans to see if the stimulation changes brain pathways linked to reward. 45 …

This study tests if a non-invasive brain stimulation technique called tDCS can help young adults (18-35) with mild depression feel better. Participants will receive either real tDCS or a sham (fake) treatment for 20 minutes a day over 2 weeks. Researchers will track mood changes …

This study watches 100 adults with treatment-resistant depression who are taking esketamine nasal spray as part of their normal care. Researchers want to see how well it works, who responds best, and how it affects daily life, work, and mood. They will also look at genetic and br…

This study is testing a digital platform that uses smartphone data (like activity and sleep patterns) to help therapists better support teens at high risk for suicide. About 78 teens aged 13-18 who are already in a treatment program will use the platform alongside their usual car…

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and let a GPS app run for four months. The goal is to understand these connections better, not to test any treatment.

This study looks at how a type of talk therapy for PTSD, called cognitive processing therapy (CPT), changes brain activity related to feeling pleasure. Researchers will use brain scans (fMRI) to see if therapy helps the brain's reward system work better. The study involves 120 ad…

This study looks at whether a non-invasive brain stimulation technique can improve the ability to seek and enjoy rewards in people with depression who have lost interest in things (anhedonia). Researchers will give 72 adults with depression five days of stimulation and measure ch…

This study follows 415 people with difficult-to-treat depression for 5 years after their original genetic testing. Researchers will review medical records and registry data to see how patients are doing, including suicide attempts and depression course. The goal is to learn which…

This study is testing a mobile phone app called TrueBlue that helps monitor depression and anxiety. It includes 125 adults who are at least 12 weeks pregnant or up to 12 weeks after giving birth. The goal is to see if the app is safe, easy to use, and agrees with standard mood qu…