ANHEDONIA

This study tested a positive emotion-focused program in 73 children (ages 8-12) whose mothers had depression and anhedonia. The goal was to see if the program could improve how their brains respond to rewards, measured by EEG. This early-stage research aims to prevent anhedonia, …

This study tested a personalized brain-training method called PRISM neurofeedback in 19 adults with major depression and anhedonia (loss of pleasure). Participants were randomly assigned to receive either real or sham (fake) training. The goal was to see if the therapy is safe an…

This study tested whether adding aticaprant to standard antidepressants helps adults with major depression who still feel little pleasure or interest (anhedonia). 444 participants received either aticaprant or a placebo pill for about 6 weeks. The main goal was to see if depressi…

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who also have anhedonia (loss of interest or pleasure). 85 adults with depression and significant anhedonia took pramipexole or a placebo alongside their usual antidepressa…

This study looked at whether adding pramipexole, a drug usually used for Parkinson's disease, can safely help people with depression who have lost the ability to feel pleasure (anhedonia). 55 adults who had already been in a shorter study took pramipexole for a longer period. Res…

This small pilot study tested whether pramipexole, a drug used for Parkinson's disease, could reduce anhedonia (loss of interest or pleasure) in people with depression. 13 adults with depression and significant anhedonia took the drug alongside their usual antidepressants. Resear…

This small pilot study tested whether psilocybin, the active ingredient in magic mushrooms, combined with psychological support could help people with treatment-resistant depression who have lost the ability to feel pleasure (anhedonia). Twenty adults with major depressive disord…

This study tested an experimental drug called ALTO-203 in 69 adults with moderate major depressive disorder and anhedonia (loss of interest or pleasure). Participants received either a low dose, a higher dose, or a placebo, and were monitored for mood changes and side effects ove…

This study tested a drug called aticaprant in 513 adults with major depression who still had symptoms—especially loss of interest or pleasure (anhedonia)—even after taking standard antidepressants. Participants took either aticaprant or a placebo pill alongside their usual antide…

This study tested a noninvasive brain stimulation technique called accelerated intermittent theta burst stimulation (aiTBS) for people with anhedonic depression—a type of depression where you lose interest or pleasure in things. 60 adults were randomly assigned to receive either …

This completed study looked at how inflammation might change the way younger women (ages 25-44) experience reward, such as money or smiling faces, and how that relates to depression. Researchers gave 40 healthy women a mild inflammatory substance or a placebo and measured their r…

This study looked at how inflammation impacts feelings of pleasure and motivation in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure these effects. The goal was to better understand the link between anxiety, inflammation, and los…

This study looked at anhedonia—a lack of motivation or pleasure—in 123 young people with depression. Participants had brain scans, blood tests, and interviews to measure symptoms. Some also tried treatments like brain stimulation (TMS), positive thinking training, or ketamine. Th…