ANHEDONIA

This study tested an experimental drug called ALTO-203 in people with moderate depression and loss of pleasure (anhedonia). Researchers gave 69 participants either the drug or a placebo to see how it affected their mood and alertness, and to check if it was safe. The goal was to …

This study tested whether a personalized form of non-invasive brain stimulation could better treat depression and loss of pleasure (anhedonia) in people who haven't responded to standard medications. Sixty adults with treatment-resistant depression received either a personalized …

This study tested whether adding a new daily pill called aticaprant to a person's current antidepressant could better treat major depression, specifically for people who experience a severe lack of pleasure (anhedonia). Over 500 adults who weren't getting enough benefit from thei…

This study tested whether adding a new drug called aticaprant to a person's current antidepressant could help improve symptoms in adults with major depression who also experience a severe loss of pleasure (anhedonia) and haven't gotten enough relief from their current medication.…

This study tested a family-focused program designed to prevent depression in children whose mothers have a history of depression. It involved 73 children aged 8-12 and their mothers, who participated in 8 online sessions. The main goal was to see if the program could improve how …

This study tested a personalized brain-training therapy called Prism neurofeedback to see if it could safely help reduce symptoms of depression, especially the loss of pleasure known as anhedonia. Nineteen adults with depression were randomly assigned to receive either the real b…

This small, early-stage study tested whether adding the drug pramipexole could help people with depression who specifically struggle with anhedonia—the inability to feel pleasure or motivation. The drug, typically used for Parkinson's disease, was given alongside participants' ex…

This study aimed to understand how inflammation might affect feelings of pleasure and motivation in older adults, particularly those with anxiety. Researchers gave 40 participants aged 60-80 either a substance that causes temporary inflammation or a placebo, then measured their m…

This study aimed to understand how temporary inflammation might affect the brain's reward system—how we anticipate and enjoy things—in women. Researchers gave 40 healthy, premenopausal women either a low-dose substance to trigger a brief inflammatory response or a placebo, then m…