Estrogen trial aims to lift Menopause-Linked depression and psychosis

NCT ID NCT05282277

Recruiting now Symptom relief Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen May 02, 2026 · Last updated May 23, 2026 · Updated 4 times

Summary

This study tests whether estradiol (a form of estrogen) can improve symptoms of depression, psychosis, and loss of pleasure in perimenopausal women aged 44-55. Participants will receive either estradiol or a placebo and undergo brain scans to see how the treatment affects reward-related brain activity. The goal is to find a new way to ease these symptoms that start during the menopause transition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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ANHEDONIA DEPRESSION PSYCHOSIS