Estrogen trial aims to lift Menopause-Linked depression and psychosis

NCT ID NCT05282277

Recruiting now Symptom relief Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen May 02, 2026 · Last updated May 23, 2026 · Updated 4 times

Summary

This study tests whether estradiol (a form of estrogen) can improve symptoms of depression, psychosis, and loss of pleasure in perimenopausal women aged 44-55. Participants will receive either estradiol or a placebo and undergo brain scans to see how the treatment affects reward-related brain activity. The goal is to find a new way to ease these symptoms that start during the menopause transition.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

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Locations

University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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ANHEDONIA DEPRESSION PSYCHOSIS