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Can a bike ride boost talk therapy for depression?

NCT ID NCT06001346

Symptom relief Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 27, 2026 · Updated 5 times

Summary

This study tested a new approach: having people with major depressive disorder do 30 minutes of moderate exercise right before a therapy session. 40 adults were split into two groups: one exercised on a stationary bike, the other watched nature videos. The goal was to see if exercise helps people connect better with their therapist and become more active in their daily lives.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aerobic exercise
What this could lead to
If it works, this could point toward a simple way to boost the effectiveness of talk therapy for depression.
What could go wrong
This is a small, early-stage study with only 40 participants. The results may not apply to everyone, and the benefit of exercise before therapy is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Sep 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with DSM-5 MDD, confirmed via SCID. * Having current depressive symptoms of at least mild severity defined by HAM-D rating ≥8. * Being between age 18 and 65. * Either not engaging in any mental health treatment (e.g., medication, psychological, or behavioral) OR on a stable mental health treatment regimen and willing to maintain it for the length of the intervention. * Willing and safe to exercise based on the Physical Activity Readiness Questionnaire. * Being CBT-naïve (as defined by never undergoing structured CBT). Exclusion Criteria: * currently pregnant, nursing, or planning to become pregnant, * severe obesity (BMI=40) * diagnosed with lifetime or current Psychosis, Mania, or Bipolar Disorder, via the SCID * diagnosed with current Substance Use Disorder, via the SCID * pose an imminent risk of self-harm or harm to others, assessed via the C-SSRS * exhibit behavioral disturbance (e.g., aggression, mild-moderate cognitive impairment) that would significantly interfere with study participation, assessed by clinical research personnel

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder

Contacts and locations

Locations

  • Iowa State University

    Ames, Iowa, 50010, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.