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Scientists hunt for hidden biomarkers to solve antidepressant failure

NCT ID NCT03118193

Knowledge-focused Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to find biological markers in blood, urine, and saliva that could help explain why up to 40% of people with depression do not respond to standard antidepressants. Researchers analyzed samples from 50 adults with major depression who had not taken antidepressants for at least two weeks. The goal was to better understand the disease and potentially guide more personalized treatment in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Jun 2017

Finished

Jan 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * between 18-60 years-old * major depressive disorder, confirmed by Mini International Neuropsychiatric Interview (MINI) * no bipolar disorder or schizophrenia, confirmed by MINI * no neurological dementia disease * able to perform olfactive tests, i.e. no anosmia and/or allergy to odors * score MADRS (Montgomery AsbergDepression Rating Scale) \>20 * no antidepressant treatment during 14 days before inclusion * informed written consent * affiliation to a social security system Exclusion Criteria: * patient who don't want any antidepressant treatment for this depressive episode * legal incapacity and/or any circumstances making the person unable to understand the trial features, purposes or consequences * participating to drug clinical study or in exclusion period of clinical study because of previous participation * pregnant woman

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

Contacts and locations

Locations

  • CHU Tours

    Tours, 37044, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.