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Resilience training shows promise for teens facing advanced cancer

NCT ID NCT03668223

Symptom relief Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a program called PRISM that teaches stress management, goal-setting, and coping skills to adolescents and young adults (ages 12-24) with advanced cancer. Researchers wanted to see if it could improve quality of life and reduce anxiety and depression. The program involves several one-on-one coaching sessions and was compared to usual care in a randomized trial across multiple hospitals.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Promoting Resilience in Stress Management (PRISM) behavioral intervention
What this could lead to
If it works, this program could help teens and young adults with advanced cancer feel better emotionally and cope more effectively with their illness.
What could go wrong
This is a completed trial with 195 participants, but the intervention is behavioral—it may not work for everyone, and benefits might be modest or not last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

195 people

The number who actually took part.

Started

Apr 2019

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 24 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 12-24 years * Diagnosed with advanced cancer: progressive, recurrent, refractory disease or any diagnosis with estimated overall survival \<50% at least 2 weeks prior to enrollment * Able to speak English * Able to read English or Spanish * Cognitively able to participate in interviews Exclusion Criteria: * Patient Refusal * Parent Refusal (if patient \<18 years-old)

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder cancer Communication communication disorder Depression depressive disorder neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Cancer Communication Coping skills Depression HOPE Quality of life

Contacts and locations

Locations

  • Children's Hospital Los Angeles

    Los Angeles, California, 900278, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98145, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

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