MS and depression: new study probes how patients read emotions
NCT ID NCT02468765
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed study looked at how depression affects the ability to recognize emotions in people with multiple sclerosis (MS). Researchers used EEG, heart rate monitoring, and questionnaires to compare emotion recognition in MS patients with and without depression, as well as healthy controls. The goal was to better understand the link between mood disorders and emotional processing in MS.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors better understand how depression impacts emotion recognition in MS, potentially leading to improved mental health support.
- What could go wrong
- This is a small, observational study with only 38 participants. It does not test a treatment, so it cannot directly improve patient outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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38 people
The number who actually took part.
- Started
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Apr 2015
- Finished
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May 2016
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Three groups will participate: Depressive MS patients, non depressive MS patients and a control group
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Man or Woman between 18 and 65 years old * Participant understanding and able to speak French * Participant understanding the Participant Informed Sheet and who has signed the Informed Consent * Participant with Health Insurance MS Patients : * Patient with relapsing remitting multiple sclerosis form * Expanded Disability Status Scale (EDSS) \< 4 * Patient without motor disorders, cerebellar or significant upper limb somatosensory or visual disturbances Control Participants : * Participant without global cognitive deterioration Exclusion Criteria: * Participant taking part of other biomedical studies involving drug tests * Participant with other neurological pathologies, head trauma with loss of consciousness, psychiatric pathologies, serious general affections, alcoholism, perception disorders, dysarthria, disorders preventing oral communication and reading, under prescription of psychotropic drugs * Mental or visual incapacity to take part in the study * Participant with antecedents of drug or alcohol abuse * Allergy to the components of the gel used during the EEG * Patients with MRI contraindications : Pacemaker or neurostimulator or Implantable Cardioverter Defibrillator (ICD), Cochlear Implants, ocular or cerebral ferromagnetic foreign body close to the nerve structures, metal prostheses, * Uncooperative or agitated patients, * Claustrophobic patients, * Ventricular peritoneal shunts and neurosurgical valves, * Braces * MS patient without MRI in the last 4 months * Adults under guardianship, under judicial protection, persons deprived of liberty, * Pregnant or breast feeding women, * MS patient with another MS form than Relapsing-Remitting, * MS patient who encountered a relapse in the last 6 weeks, * MS patient treated with corticoids in the last month.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Saint Vincent de Paul (GHICL)
Lille, Hauts-de-France, 59000, France
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