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Online CBT shows promise for treating depression in rural communities

NCT ID NCT04120285

Symptom relief Sponsor: University of South Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving primary care doctors access to an online cognitive behavior therapy program helps treat major depression in rural West Virginia and Kentucky. Over 1,200 adults participated. The goal was to see if remote therapy can improve depression remission rates and be a practical option where mental health services are scarce.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote internet-based cognitive behavior therapy (eCBT)
What this could lead to
If successful, this could provide an effective, accessible treatment option for depression in rural areas with limited mental health resources.
What could go wrong
This is a completed study, but results may not apply to all populations. Online therapy may not work for everyone, and access to technology is required.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,280 people

The number who actually took part.

Started

Jan 2021

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. seeking MDD treatment for the first time in the past 6 months (i.e., the beginning of a first or new course of treatment), 2. appropriate for outpatient treatment, 3. literate in English, 4. has access to a smart phone, home computer or willing to travel to access a computer 5. without hearing or vision or cognitive impairment that would interfere with research data collection 6. without history of either bipolar disorder or non-affective psychosis.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder

Contacts and locations

Locations

  • Harpers Ferry Family Medicine

    Harpers Ferry, West Virginia, 25425, United States

  • Minnie Hamilton Health Systems

    Glenville, West Virginia, 26351, United States

  • Minnie Hamilton Health Systems

    Grantsville, West Virginia, 26147, United States

  • University of Lousiville Health

    Louisville, Kentucky, 40202, United States

  • Upper Kanawha Clinic

    Cedar Grove, West Virginia, 25039, United States

  • WVU Medicine

    Morgantown, West Virginia, 26505, United States

  • Wayne Medical Clinic

    Wayne, West Virginia, 25570, United States

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