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Brain training with EEG and MRI shows promise for depression

NCT ID NCT04450186

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help improve lingering cognitive problems after a depressive episode. The study involved 31 adults and was designed to prepare for a larger trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EEG/fMRI neurofeedback
What this could lead to
If successful, this could point toward a new non-drug therapy for depression that helps patients train their own brain activity to reduce symptoms.
What could go wrong
This is a very small pilot study (31 people) testing feasibility, not effectiveness. Results may not apply to all depressed patients, and the technique is still experimental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Aug 2020

Finished

Apr 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18 to 65 years old 2. Signature of an informed consent after being given clear and loyal oral and written information Exclusion Criteria: Related to the volunteer 1. Prior experience of a neurofeedback task Related to the MRI 2. Implanted cardiac pacemaker of defibrillator 3. Brain aneurysm clip 4. Cochlear implant 5. Ocular on encephalic metallic foreign body 6. Endoprothesis implanted for less than 4 weeks and ostheosynthesis device implanted for less than 6 weeks. 7. Claustrophobia Other criteria 8. Unstable hemodynamic status 9. Acute respiratory failure 10. Alteration of general state or continuous monitoring requirement 11. Other psychiatric condition (DSM-5) such as schizophrenia, substance abuse… 12. Neurological condition or diagnosis of dementia in medical history 13. Undergoing treatment by benzodiazepines or anticonvulsants prescribed less than a month prior to inclusion 14. Undergoing treatment influencing the blood flow prescribed less than three weeks prior to inclusion 15. Protected person (adults legally protected (under judicial protection, guardianship or supervision), person deprived of their liberty, pregnant woman, lactating woman and minor)

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

Contacts and locations

Locations

  • CHU

    Rennes, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.