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Brain training shows promise for bipolar thinking problems

NCT ID NCT01470781

Symptom relief Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a computer program called BrainWorks that uses fun games to train thinking skills like memory, attention, and problem-solving. 72 adults with bipolar disorder and psychosis played these games over several sessions. Researchers measured changes in cognitive abilities and daily functioning compared to a control group. The goal was to see if this brain training could help with the thinking problems that often come with bipolar disorder.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BrainWorks computer-based cognitive training program
What this could lead to
If it works, this could point toward a non-drug way to sharpen memory, attention, and problem-solving skills in people with bipolar disorder.
What could go wrong
This is a small, completed study with only 72 participants, so results may not apply to everyone. The training is time-consuming and may not improve real-world functioning.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Start date

Jun 2011

Finished

Aug 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of BD with psychosis * Positive and Negative syndrome Scale (PANSS) \< 75; PANSS Psychosis item scores = 3 or under; Young Mania Rating Scale (YMRS) = 6 or under * Age between 18 and 50 * Within 10 years of illness onset * Legal and mental competency of the participant Exclusion Criteria: * Age under 18 or over 50 * PANSS \>75; PANSS Psychosis item scores \>3; YMRS \> 6 * Legal or mental incompetence (legal incompetence defined by any guardianship (including of person or treatment guardianship); mental incompetence defined by failure of the informed consent survey) * Psychiatric inpatient status at time of enrollment * Delirium secondary to medical illness * Psychotic or mood disorder due to general medical or neurological illness * History of head trauma * History of seizure disorder or photo-sensitive seizures * Use of anticholinergic medication, clozapine or olanzapine at baseline * Rapid-cycling bipolar disorder * Diagnosis of current substance abuse (past month) or substance dependence within the past year.

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Conditions

The condition(s) this trial relates to.

bipolar disorder psychotic disorder Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar disorder Psychosis

Contacts and locations

Locations

  • McLean Hospital

    Belmont, Massachusetts, 02478, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.