Mclean Hospital

This study tests whether taking magnesium and vitamin B6 alongside usual treatment can reduce symptoms of depression, anxiety, and stress in people who recently started experiencing bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years will r…

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial problems. Researchers will give MitoQ or a placebo to 50 eligible participants for 12 weeks, alongside their usual medicat…

This early-stage study tests whether adding D-serine (a supplement) to transcranial magnetic stimulation (TMS) can better relieve depression symptoms. About 60 adults with major depressive disorder will receive 30 TMS sessions plus either D-serine or a placebo pill. The goal is t…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce symptoms like psychosis, depression, and mania in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alo…

This study tests a digital program called Cognitive Bias Modification for Interpretation (CBM-I) in adults with obsessive-compulsive disorder (OCD). The program aims to change how people automatically interpret situations, which may reduce OCD symptoms. Participants will be rando…

This study tests a custom high-CBD product to see if it can ease anxiety and depression in people with bipolar disorder. Over 4 weeks, 25 adults with stable medication will take CBD and report their symptoms. It is an early-phase trial to gather initial data on safety and effecti…

This study tests a custom, hemp-derived CBD product against a placebo to see if it can reduce pain and improve quality of life in people with endometriosis. Researchers will track pain levels and other symptoms over 12 weeks. The goal is to provide much-needed evidence on whether…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants from six clinics will either get standard care or the enhanced versio…

This study aims to figure out why exposure therapy helps some people with OCD but not others. Researchers will track 400 adults with OCD during therapy sessions, using surveys, behavior observations, and wristwatch sensors to measure body responses. The goal is to identify which …

This study aims to understand how a non-invasive brain stimulation technique called continuous theta-burst stimulation (cTBS) affects brain activity in people with major depression. Researchers will give participants a single dose of different FDA-approved medications that boost …

This study looks at whether a non-invasive magnetic stimulation technique can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve challenging tasks. About 95 participants will do thinking exercises and get brain scans before and afte…

This study looks at how a mindfulness app might help teenagers who tend to overthink (ruminate). About 158 teens aged 13-18 will be randomly assigned to use the app or a control activity. Researchers will use brain scans and smartphone surveys to see if the app changes brain conn…

This study looks at whether teaching parents to interpret ambiguous situations less negatively can reduce anxiety in their children. Researchers will enroll 300 parents and their children (ages 7-12). Parents will use a smartphone app for four weeks to practice thinking in a less…

This study looks at how severe childhood stress may change the brain and increase the risk of depression. Researchers will use brain scans to measure chemical changes and brain activity in 160 women aged 20 to 32. The goal is to understand why some people stay mentally healthy de…

This study aims to create a new tool to measure the consequences of substance use in people with substance use disorder. Researchers will interview patients, their close friends or family, and healthcare providers to develop the tool. The goal is to better understand and track tr…

This study looks at how stress affects the brain, body, and behavior in teenage girls who have a parent with depression. Researchers will use brain scans, smartphone surveys, and smartwatches to track stress responses in real time. The goal is to find early signs that could predi…

This study looks at how a specific brain system (nociceptin) works in people with current or past major depression. Researchers will use brain scans, blood and saliva tests, and decision-making tasks to understand depression better. The goal is to find new ways to predict and tre…

This study uses a safe, noninvasive brain stimulation technique called TMS to learn how hallucinations happen in people with schizophrenia or schizoaffective disorder. Researchers will measure brain activity and symptom changes in 68 participants before and after TMS. The goal is…

This study tests an experimental drug to see if it can change how the brain processes decisions involving reward or risk in people with major depression or anxiety disorders. Participants will undergo brain scans and complete behavioral tasks while taking the drug or a placebo. T…