Mclean Hospital

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can improve brain energy use and reduce stress in people with mild memory problems or early Alzheimer's. Researchers will measure changes in brain chemistry and thinking skills over ti…

This early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who had significant anxiety or agitation. The goal was to see if it could reduce these behavioral symptoms safely. The stud…

This study follows 1,600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how pe…

This study looks at how people who have had major depression in the past make decisions when faced with choices that involve risk or reward. Researchers use brain scans (MRI) and computer tasks to see which brain areas are active during these decisions. The goal is to find patter…

This study looks at how childhood abuse affects the brain and causes dissociation (feeling detached from yourself or reality). Researchers will use MRI scans and thinking tests in about 200 women with PTSD or Dissociative Identity Disorder, plus healthy volunteers. The goal is to…

This study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. About 40 participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects…

This study was designed to test whether a drug called lorcaserin could reduce cocaine cravings and impulsive behavior by rebalancing serotonin levels in the brain. It planned to enroll 18- to 55-year-olds who used cocaine at least four times in the past month. However, the study …

This study was designed to see if a drug called LY-2940094 could protect healthy people from developing depression or anxiety after stress. Researchers planned to measure brain responses to rewards and fear using tasks and questionnaires. However, the study was withdrawn before a…