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Brain scans reveal hidden scars of childhood abuse in women

NCT ID NCT02757339

Knowledge-focused Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how childhood abuse and neglect change the brain in women with PTSD or dissociative identity disorder. Researchers will use MRI scans and cognitive tests to measure brain activity related to attention, emotions, and feelings of detachment. The goal is to better understand the biology behind traumatic dissociation, which could one day lead to improved treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help explain the brain basis of dissociation after trauma, pointing toward better diagnosis or targeted therapies.
What could go wrong
This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to men or other groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2015

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will enroll up to 90 female patients with either DID or PTSD ages 18-89. We will also recruit up to 60 control subjects matched for demographics (age, race, gender).

Ages

18 to 89 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female * Clinical diagnosis of PTSD or DID and history of childhood abuse, or healthy controls * Age between 18 and 89 * Legal and mental competency of the patient Exclusion Criteria: * Male * Under 18 or over 89 * Legal or mental incompetence * Delirium secondary to medical illness * PTSD or DID due to general medical or neurological illness * History of neurological conditions that may cause significant psychiatric symptomatology (e.g., dementia) * Any contraindication to MR scans, including claustrophobia, pregnancy, metal implants, etc. * Current alcohol or substance dependence or abuse (within the last month) * A history of schizophrenia or other psychotic disorder * History of head injury or loss of consciousness for longer than 5 min (including concussion)

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Conditions

The condition(s) this trial relates to.

multiple personality disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dissociative identity disorder Posttraumatic stress disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • McLean Hospital

    Belmont, Massachusetts, 02478, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.