MRI reveals brain differences in violent suicide attempts
NCT ID NCT05230043
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity patterns linked to violent suicide attempts, which could help improve prevention.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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40 people
The number who actually took part.
- Started
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Mar 2022
- Finished
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Sep 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Four groups of participants will be recruited: 1. 20 individuals with personal history of mood disorder (bipolar disorder or depressive disorders) and at least one suicidal act committed with a violent means within the last 12 months. 2. 20 individuals with personal history of mood disorder (bipolar disorder or depressive disorders) and at least one suicidal act conducted within the last 12 months but no lifetime history of suicidal act with a violent means. 3. 20 individuals with personal history of mood disorder (bipolar disorder or depressive disorders) who never attempted suicide and have no family history of suicidal behavior up to the second biological degree. 4. 20 individuals with no personal history of major mental disorder or suicidal act and no family history of suicidal behavior up to the second biological degree.
- Ages
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18 to 60 years
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Right-handed (as assessed with the Edinburgh Handedness Scale). * Agreement to participate and sign the informed consent form. * Is insured or beneficiary of a health insurance plan. * Speaks French. * Suicide Attempters using Violent Means group: * a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0); * at least one suicidal act committed with a violent means within the last 5 years. * Suicide Attempters using Non-Violent Means group: * a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0); * at least one suicidal act conducted within the last 5 years; * no lifetime history of suicidal act with a violent means. * Patient Control group: * a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0); * never attempted suicide in their lifetime; * no family history of suicidal behavior up to the second biological degree. * Healthy Control group: * no personal history of major mental disorder according to the MINI 7.0; * never attempted suicide in their lifetime; * no family history of suicidal behavior up to the second biological degree. Exclusion Criteria: * Current participation or in the exclusion period of another research protocol in a category 1 RIPH * Currently under judicial protection, or under adult guardianship. * Refusal to participate. * Is pregnant or breast feeding. * The suicide attempt may have impacted the brain functioning (e.g. following hanging, asphyxia by drowning, head trauma following jumping from height, bullet impact, etc). This criteria will be assessed clinically by the investigator. * Mental retardation (known or observed during the interview). * Current psychotic disorder (according to the MINI 7.0). * Current hypomanic episode (according to the MINI 7.0). * Current manic, mixed, rapid cycling episodes (according to the MINI 7.0). * Alcohol or substance disorder within last 3 months (according to the MINI 7.0). * Past major brain trauma (with loss of consciousness \> 1 minute). * Contra-indication to MRI (metal in body (including due to suicidal act), claustrophobia, impossibility to lie still on the back during one hour). * Electroconvulsive therapy within the last three months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de Nimes
Nîmes, France
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Other studies related to the condition(s) this trial covers.
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