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MRI reveals brain differences in violent suicide attempts

NCT ID NCT05230043

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity patterns linked to violent suicide attempts, which could help improve prevention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Mar 2022

Finished

Sep 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Four groups of participants will be recruited: 1. 20 individuals with personal history of mood disorder (bipolar disorder or depressive disorders) and at least one suicidal act committed with a violent means within the last 12 months. 2. 20 individuals with personal history of mood disorder (bipolar disorder or depressive disorders) and at least one suicidal act conducted within the last 12 months but no lifetime history of suicidal act with a violent means. 3. 20 individuals with personal history of mood disorder (bipolar disorder or depressive disorders) who never attempted suicide and have no family history of suicidal behavior up to the second biological degree. 4. 20 individuals with no personal history of major mental disorder or suicidal act and no family history of suicidal behavior up to the second biological degree.

Ages

18 to 60 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Right-handed (as assessed with the Edinburgh Handedness Scale). * Agreement to participate and sign the informed consent form. * Is insured or beneficiary of a health insurance plan. * Speaks French. * Suicide Attempters using Violent Means group: * a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0); * at least one suicidal act committed with a violent means within the last 5 years. * Suicide Attempters using Non-Violent Means group: * a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0); * at least one suicidal act conducted within the last 5 years; * no lifetime history of suicidal act with a violent means. * Patient Control group: * a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0); * never attempted suicide in their lifetime; * no family history of suicidal behavior up to the second biological degree. * Healthy Control group: * no personal history of major mental disorder according to the MINI 7.0; * never attempted suicide in their lifetime; * no family history of suicidal behavior up to the second biological degree. Exclusion Criteria: * Current participation or in the exclusion period of another research protocol in a category 1 RIPH * Currently under judicial protection, or under adult guardianship. * Refusal to participate. * Is pregnant or breast feeding. * The suicide attempt may have impacted the brain functioning (e.g. following hanging, asphyxia by drowning, head trauma following jumping from height, bullet impact, etc). This criteria will be assessed clinically by the investigator. * Mental retardation (known or observed during the interview). * Current psychotic disorder (according to the MINI 7.0). * Current hypomanic episode (according to the MINI 7.0). * Current manic, mixed, rapid cycling episodes (according to the MINI 7.0). * Alcohol or substance disorder within last 3 months (according to the MINI 7.0). * Past major brain trauma (with loss of consciousness \> 1 minute). * Contra-indication to MRI (metal in body (including due to suicidal act), claustrophobia, impossibility to lie still on the back during one hour). * Electroconvulsive therapy within the last three months.

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Conditions

The condition(s) this trial relates to.

mood disorder Suicide, Attempted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU de Nimes

    Nîmes, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.