Injury

This trial tests whether a spinal cord stimulator, implanted surgically, combined with intensive motor rehabilitation can help people with spinal cord injury regain the ability to stand and step. Ten adults with complete or incomplete spinal cord injury who cannot currently stand…

This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics…

This study tested whether adding the antibiotic rifampicin to the standard antiseptic povidone-iodine could improve wound healing and prevent infection after hair transplantation. 65 adults were randomly assigned to receive either the combination or the standard antiseptic alone.…

Researchers are studying how the antibiotic ertapenem behaves in patients with severe burns who are on breathing machines. The trial measures drug levels in the blood after two intravenous doses to see how the body processes the medicine. They also check whether a standard 1-gram…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This trial tests two types of plates used to fix a specific kind of jaw fracture, called a subcondylar fracture. One plate is made of titanium, the standard metal. The other is made of PEEK, a medical plastic that can be 3D-printed. Researchers will compare how well each plate re…

This trial tests two mechanical ventilation strategies in adults with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition that makes breathing difficult. Half the participants receive airway pressure release ventilation (APRV), while the other …

This trial tests a new way to treat deep skin wounds that need a graft. Researchers add a patient's own epidermal stem cells, prepared during surgery, to a standard composite graft made of a dermal matrix and a thin skin layer. The goal is to see if this addition improves wound h…

This trial tests whether regular walking with a robotic exoskeleton can improve bone health and quality of life in people with spinal cord injury. Participants will train three times a week for 26 weeks, aiming for an hour of continuous walking each session. Researchers will meas…

This trial tests whether a gel made from fucoidan, a compound found in seaweed, can improve healing and bone regrowth in people with gum disease. The study enrolls 5 systemically healthy adults aged 25 to 55 who have periodontitis with bone defects around teeth or implants. After…

This trial tests a counseling program called ImpACT+ for women in South Africa who have HIV and a history of sexual trauma. The program combines HIV treatment adherence support with coping skills to address traumatic stress. Researchers will compare viral suppression rates and ca…

This trial is testing an implantable wireless brain-computer interface (BCI) called NEO in people with tetraplegia caused by cervical spinal cord injury. The device is designed to let participants control external equipment using their brain signals, potentially improving their a…

This study tests whether a non-invasive nerve stimulation on the leg, called transcutaneous tibial nerve stimulation (TTNS), can help maintain bladder function in people with recent spinal cord injury. Researchers will enroll 120 adults with spinal injuries at level T9 or above, …

This trial compares two surgical techniques for repairing a common type of hip fracture in older adults: dynamic locking, which allows slight movement at the nail's end, versus static locking, which holds it rigidly. The goal is to see which approach leads to less thigh pain and …

This early study tests an implanted device called the Intelligent Spine Interface (ISI-C) in people with spinal cord injuries. The device is designed to bridge the gap in the spinal cord, picking up signals from above the injury and sending them to nerves below. The goal is to un…

This trial tests whether deliberately cooling the body to 34-35°C for five days after a severe traumatic brain injury improves neurological recovery at six months, compared with standard care that keeps temperature normal. Adults aged 18-65 with a closed head injury and high pres…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This trial tests whether injecting bone cement into a recently fractured vertebra (vertebroplasty) reduces disability better than wearing a brace. Adults aged 18–70 with a traumatic spinal fracture (within 15 days) are randomly assigned to one of the two treatments. The study mea…

This trial tests whether a spinal implant that delivers electrical stimulation, combined with robot-assisted rehabilitation, can improve walking ability in people with chronic spinal cord injury. Participants will have a device implanted and then undergo months of training. The g…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested whether ketotifen, an allergy medicine, can prevent elbow stiffness after a fracture or dislocation. 395 adults took either a low or high dose of ketotifen or a placebo pill twice daily for 6 weeks. The main goal was to see if the drug improved elbow range of mo…

This study tested whether adding tobramycin powder to the standard vancomycin powder in the wound during surgery reduces infections after high-risk leg fracture repair. About 1,550 adults with tibial plateau or pilon fractures at high infection risk took part. The main goal was t…

This trial looks at two non-surgical approaches for treating a broken wrist (distal radius fracture). One group receives finger-trap traction followed by a cast, while the other gets a local anesthetic injection into the fracture site, then traction and manual realignment before …

This study tests whether a personalized training program guided by machine learning can reduce time-loss injuries and improve performance in elite track and field athletes. Over a 9-month season, 120 athletes aged 18–35 will either follow the adaptive, data-driven plan or a stand…

This study tests whether adding Nintendo Switch active video games to standard occupational therapy can reduce fall risk and improve balance in adults with weakness on one side of the body (hemiparesis) after a stroke or other brain injury. Participants play games like Ring Fit A…

This trial investigates whether placing vancomycin antibiotic powder directly into the wound during surgery can reduce deep surgical site infections in people with severe tibial plateau fractures. Participants are adults with high-energy fractures requiring plate and screw fixati…

This study tests whether a custom-designed brace called the IDEO, combined with a physical therapy program called Return to Run, can improve physical function in people with traumatic leg injuries. Participants are adults aged 18 to 60 who are at least two years past a leg injury…

This study looked at using bioabsorbable (dissolvable) screws instead of metal screws to fix a specific type of ankle injury called syndesmosis disruption. The goal was to see if these screws could hold the bones in place while they heal, then naturally dissolve, avoiding the nee…

This study looked at 442 people with severe open fractures of the shin bone (tibia). It compared two surgical approaches: using a modern ring external fixator (a frame outside the leg) versus internal fixation (a metal rod or plate placed inside the bone). The main goal was to se…

This study tested whether adding albumin (a protein) to standard IV fluids helps adults with severe burns covering at least 25% of their body. 101 participants were randomly assigned to receive either standard fluids alone or standard fluids plus albumin during the first 24-48 ho…

This study tested a special bandage (dressing) that contains a germ-killing ingredient called chlorhexidine for IV tubes placed in the arm. The goal was to see if it reduces infections and other complications compared to the standard bandage. About 300 patients in Australia and F…

This study compared two ways to cover deep wounds on the lower leg, ankle, or foot: a synthetic skin patch called Integra versus traditional flap surgery (moving skin from another body part). 72 patients with traumatic skin loss were enrolled. The goal was to see which method lea…

This pilot study tested a standardized 5-step weaning procedure to safely remove tracheostomy tubes in 30 brain-injury patients. The procedure involves steps like deflating the tube cuff and using a speaking valve, with a team of doctors and nurses monitoring stability. The goal …

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone dr…

This study tested a Norwegian intensive habilitation program for children aged 2-6 with severe cerebral palsy or similar brain damage. The program aimed to improve the child's daily living skills and empower parents. 93 children and their families took part in a randomized trial …

This study looked at whether a menstrual cup can help women with vesicovaginal fistula (VVF) manage urine leakage while waiting for surgery. Eleven women in Ghana tested the cup, and researchers measured how much urine leaked with and without it. They also asked about comfort and…

This study tested a new surgical device called the Femoral Neck System (FNS) for fixing a common type of hip fracture. Researchers wanted to see how often patients needed another surgery after the implant. The study included 43 adults with hip fractures and followed them for one …

This study tested whether giving patients extra oxygen (80% FiO2) during surgery could reduce surgical site infections after severe tibial plateau or pilon fractures. Over 1,100 patients were randomly assigned to receive either supplemental oxygen or standard care. The main goal …

This study tested a device that automatically adjusts oxygen levels for hospitalized patients with serious injuries or illnesses. 300 adults received either the automated device or standard manual oxygen adjustments. The goal was to see if the device kept oxygen levels in a safer…

This study looked at how well the Gamma4 nail system works for fixing thigh bone fractures. 100 adults who needed this surgery were followed for a year to see if their bones healed and to check for any problems. The goal was to see if the nail helps bones heal properly without ca…

This study tested a short, motivational counseling session for injured patients who drink alcohol, delivered in the emergency department in Tanzania. Over 600 adults took part, and the goal was to see if the intervention could reduce binge drinking and related harms. The approach…

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study tested whether giving a clotting factor concentrate (4F-PCC) early to people with severe traumatic bleeding could reduce organ failure and death. 380 patients were randomly assigned to receive either standard care or standard care plus 4F-PCC within 2 hours of hospital…

This study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…

This study tested a new type of prosthetic leg for people who have lost a leg below or above the knee. The smart leg uses sensors to detect muscle signals and provides gentle vibrations to help the user feel the leg's position. It also has powered knee and ankle joints that activ…

This study tested whether giving a single, strong dose of steroids to people right after a major heart attack (STEMI) could reduce the amount of heart muscle that gets permanently damaged. The steroid was given before the standard emergency procedure to open the blocked artery. T…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIC) could improve blood flow and reduce tissue damage in women undergoing breast reconstruction with a free flap. RIC involves using a blood pressure cuff on the upper arm to create short …

This study tested whether a daily supplement made from kefir peptides could help heal broken bones faster in postmenopausal women with osteoporosis. Thirty women with upper arm or wrist fractures were randomly assigned to receive either the kefir supplement or standard care alone…

This study tested a new rehabilitation approach for people with spinal cord injury. Ten participants received a spinal cord stimulation implant and used a robotic exoskeleton to help them walk. The goal was to improve leg muscle strength and overall quality of life. The combinati…

This study tested a closed-loop ventilation system (INTELLiVENT-ASV) in 20 adults with acute brain injury who needed a breathing machine. The goal was to see if this smart system could provide safer, more effective breathing support compared to standard ventilation. Researchers m…

This study tested whether putting antibiotic powder (vancomycin or tobramycin) directly into open fracture wounds right after injury can prevent infections. Twenty adults with severe open fractures of the arm or leg took part. The goal was to see if this simple step reduces surgi…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study tested whether continuously monitoring the pressure in the breathing tube cuff (using a ventilator system) could reduce pneumonia compared to manual checks every 8 hours. It involved 40 ICU patients with severe head injury who needed a breathing machine. The goal was t…

This study tested whether combining a mild brain stimulation technique (tDCS) with a new mental and physical rehab method (NEUROM) can help people with chronic spinal cord injury regain leg movement and feeling. Fifty-six participants with paralysis below the lower back were rand…

This study tested whether giving low-titer type O whole blood to injured patients at risk of severe bleeding, before they reach the hospital, works better than standard care (fluids or blood components). Over 1,000 patients from 10 trauma centers took part. The main goal was to s…

This study tested an experimental drug called elezanumab in people with a recent cervical spinal cord injury. The goal was to see if the drug could improve arm and hand movement and was safe. About 60 adults aged 18-75 with severe neck-level injuries received either the drug or a…

This study looked at whether the drug dexmedetomidine, given during laparoscopic surgery for rectal or sigmoid colon cancer, can protect the lungs of patients aged 60 and older. The trial included 64 participants and measured oxygen levels and other breathing indicators. The goal…

This study looked at how safe and effective the JuniOrtho plating system is for treating congenital deformities and fractures in the lower limbs of 30 children and adults. The device is a metal plate and screws used during surgery to hold bones in place while they heal. Researche…

This study looked at whether giving whole blood (all blood parts together) works as well as giving separate blood parts (red cells, plasma, platelets) to people with severe bleeding from trauma. About 200 patients who needed a massive transfusion were included. The goal was to se…

This study looked at two ways to treat a rare break in the jaw joint (condylar head fracture): surgery to fix the bone, or non-surgical care with advice and exercises. 14 adults with this injury took part. The goal was to see which approach leads to better chewing and jaw functio…

This study tested whether cooling the brain based on its own temperature, rather than body temperature, improves fever control in severe brain injury patients. 41 adults with brain injury and fever were enrolled. The intervention group used an external cooling device guided by br…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study looked at whether a specific heart procedure, done a few minutes after blood flow returns naturally, can limit heart muscle damage in people having a major heart attack. 72 adults with a first heart attack and partially open arteries took part. Researchers measured hea…

This study tested two common treatments for depression and PTSD—talk therapy (IPT) and an antidepressant (fluoxetine)—in a large public hospital in Kenya. Over 2,100 adults participated to see if these treatments could be effectively delivered by non-specialists in primary care. …

This study looked at whether giving a single dose of tranexamic acid before surgery can reduce blood loss in adults with broken thigh bones. The trial involved 43 patients in Uganda who had open surgery to fix their fracture. The goal is to see if this common, low-cost drug can l…

This study tested whether applying a gel made from a patient's own blood (i-PRF) to the extraction site after wisdom tooth removal helps the socket heal better than standard surgery alone. Thirty-two healthy, non-smoking adults had both lower wisdom teeth removed, with one side r…

This early-stage trial tested the drug olaparib (a PARP inhibitor) given alongside radiation therapy for people with triple-negative breast cancer that is advanced or has come back. The main goal was to find the safest dose of olaparib when used with radiation, and to watch for s…

This study tested whether custom-made titanium plates, designed from CT scans and 3D printing, work better than standard lambda plates for fixing broken jaw joints. Twenty-four adults with subcondylar fractures were treated with one of the two plates. Researchers measured surgery…

This study tested whether fresh frozen plasma (FFP) works better than albumin for fluid replacement in adults with severe burns covering over 20% of their body. Fifty-nine participants were randomly assigned to receive either FFP or albumin within 8 hours of injury. The goal was …

This study tested whether a special type of hip implant (dual mobility cup) can prevent the hip from popping out of place after a total hip replacement for a broken hip. The trial involved 1,600 elderly patients with a specific type of hip fracture. Researchers compared the dual …

This study tested a new custom-designed omega-shaped bone plate against standard metal plates for fixing broken jaws in the chin area. Twelve adults with such fractures were split into two groups, one receiving the custom plate and the other the standard one. The custom plates we…

This study tested whether a dressing soaked in heparin, a blood-thinning medicine, can prevent thick, raised scars and reduce pain at the site where skin is taken for a graft. 400 patients each had one donor site treated with standard care and the other with a heparin dressing. T…

This study tested a robotic system called EPIONE that helps doctors guide needles into bones during CT scans. The robot is used for procedures like biopsies, tumor treatments, and bone repairs. Researchers wanted to see if the robot could make these procedures safer and more accu…

This study tested whether a beta-blocker eye drop called timolol, applied directly to the wound, can help heal venous leg ulcers that have not improved with standard care. Forty-two adults with ulcers lasting at least 24 weeks received either timolol plus standard wound care or s…

This study tested whether a brain-computer interface (BCI) training program could improve hand and arm function in people with recent spinal cord injuries. Thirty participants used a system that reads brain signals during hand motor imagery exercises. The goal was to see if this …

This study tested whether a single injection of cyclosporine, given right before opening a blocked artery, could improve outcomes for people having a major heart attack. About 970 patients received either cyclosporine or a placebo. Researchers tracked deaths, hospitalizations for…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

Researchers are comparing two scoring systems, the Chest Trauma Score and the Thoracic Trauma Severity Score, to see which one better predicts complications and death in adults with blunt chest injuries. The study enrolls 60 patients aged 18 and older who arrive at the hospital w…

Researchers are comparing two injury severity scoring systems, the New Injury Severity Score (NISS) and the Injury Severity Score (ISS), to see which one better predicts death in blunt trauma patients. The study enrolls 458 trauma patients admitted to emergency rooms in Iraq. Upo…

Visual problems after a mild traumatic brain injury often go unnoticed. Researchers at Bispebjerg Hospital are developing and testing a 42-item questionnaire and eye-tracking based screening tools to detect these issues. The study compares 100 adults with persistent symptoms afte…

Researchers are testing whether a special type of MRI, called diffusion tensor imaging, can detect subtle damage to the brain's white matter after a sports concussion. Standard brain scans often look normal after a concussion, even when athletes have lingering symptoms. This stud…

This trial tests whether contrast-enhanced ultrasound can detect spinal cord injury during decompression surgery for chronic spinal cord compression. Researchers inject an ultrasound contrast agent before, during, and after the procedure to visualize blood flow changes in the spi…

This study tests whether a handheld, noninvasive device called the Infrascanner Model 2500 can help doctors detect brain hemorrhages faster in people with suspected traumatic brain injury from combat. The device uses near-infrared light to spot bleeding inside the skull. Research…

This study tests whether artificial intelligence (AI) can help emergency room doctors find broken bones, dislocations, and other bone problems more quickly and accurately. About 4,800 patients with arm or leg injuries will have their X-rays reviewed either with or without AI assi…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This trial tests whether a portable ultrasound device, used at the patient's bedside, can accurately detect hip fractures after a fall or injury. Researchers will compare ultrasound findings with standard X-rays in 146 adults with suspected hip fractures. If proven reliable, ultr…

This study looks at whether a new DNA sequencing technology (Nanopore) can better identify infections in broken bones compared to standard lab cultures. Researchers will collect bone samples from 100 adults with fracture-related infections and compare the results from both method…

This study tested a new imaging method called 3D-DXA to measure bone density in the spine, comparing it to standard CT scans. Researchers enrolled 120 adults who already needed a CT scan. The goal was to see if the 3D-DXA technique, which uses less radiation, could give equally a…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can help doctors safely avoid CT scans in children with mild traumatic brain injury. Over 1,500 children across Europe participated. The goal was to see if these blood tests are accurate enough to …

This study tested a new, rapid MRI method in 102 infants with brachial plexus birth palsy (nerve damage from birth). The goal was to see if the MRI could help doctors decide earlier and more accurately whether the baby needs nerve surgery. The MRI was done without anesthesia, and…

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could sa…

This study compared the accuracy of bedside ultrasound (POCUS) with standard X-rays for diagnosing elbow fractures in 90 adults with indirect elbow trauma. Using CT scans as the gold standard, researchers aimed to see if ultrasound could be a reliable first-line tool. If proven a…

This study tested a new, low-cost tool called the Intensive Care Infection Score (ICIS) to see if it can better detect bacterial infections in burn patients compared to standard blood tests. Researchers studied 97 adults and children hospitalized for burns. The goal was to improv…

This study tested whether measuring S100B protein levels in the blood can safely rule out serious brain injuries in adults with minor head trauma who take antiplatelet drugs (blood thinners). 720 participants had a blood test upon arriving at the emergency room, followed by a CT …

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can safely tell doctors when an older adult with a mild head injury does not need a CT scan. Over 2,200 participants aged 65 and older were enrolled. The goal is to reduce unnecessary radiation and…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study tested whether a new ultra low-dose CT scanner can find bone fractures as well as standard X-rays, but with less radiation. Over 500 emergency patients with suspected breaks in the spine, pelvis, or limbs were scanned using both methods. The goal was to see if the low-…

This study tested whether an AI tool called Boneview helps clinicians spot fractures on X-rays more accurately. 18 doctors and other health professionals reviewed 500 X-ray images, half with fractures and half without, first without AI and then with AI assistance. The goal was to…

This study tested whether a cone-beam CT scanner (Newtom 5G) can detect and classify fractures of the arms and legs as accurately as a standard CT scan. 43 adults with suspected fractures received both scans. Researchers compared how well each scan identified the type of fracture…

This study tested whether an ultrasound of the optic nerve sheath (the lining around the nerve connecting the eye to the brain) can accurately detect dangerously high pressure inside the skull in children. Researchers measured the nerve sheath diameter in 230 children with brain …

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 d…

Researchers at the University of Ljubljana studied whether a 12-week ankle strength training program changes muscle strength and walking mechanics in healthy, active men aged 18 to 50. Participants trained on a device that isolates the muscles that turn the foot outward and inwar…

Patients on a breathing machine need the cuff around their endotracheal tube kept at about 25 cmH2O to seal the airway. Nurses usually check and adjust this pressure by hand every few hours, which can let the pressure drop too low between checks. This trial tests whether a mechan…

Researchers test whether a body awareness program called ROAF can reduce imbalance injuries in military personnel. Five hundred people enrolled in a selection camp receive either six one-hour ROAF workshops or six one-hour cognitive training sessions. The trial tracks injury rate…

This study tested a household safety intervention for veterans with elevated suicide risk. The program involved discussions about safely storing firearms and medications, plus providing free safety devices. Researchers enrolled 40 veterans from VA healthcare settings to see if th…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested a program called Family Safety Net in rural Alaska. It aimed to help families store firearms safely to prevent suicide and accidental injuries. 58 adults who lived with guns took part. Some received a counseling session, others a scripted talk, and all got free …

This study tested two approaches to prevent serious fall injuries in older adults (65+) who had a prior bone fracture. One group received enhanced usual care, while the other received exercise coaching. Researchers tracked serious fall injuries, falls, and overall health over 36 …

This study looked at whether the Functional Movement Screen™ (FMS™) can predict injuries in amateur rugby players. Twenty healthy adult players from Normandy were tested at the start and end of the season, and their injuries were tracked. The goal was to see if a low FMS™ score c…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested a special dressing coated with a spider-silk-like chemical (DACC) to see if it prevents infections after vascular surgery. Over 700 adults in the UK were randomly assigned to get either the DACC dressing or a standard one. Researchers checked for infections at 3…

This study looked at whether home safety assessments and modifications could reduce injury risks for children under 7 in low-income households. Researchers visited 300 homes, identified hazards like unlocked poisons, missing smoke alarms, and unsecured furniture, then provided fi…

This study tested a small clip attached to the breathing tube used during anesthesia to see if it could prevent sore throat, voice changes, and trouble swallowing after surgery. 100 adults having surgery with general anesthesia took part. The clip is designed to reduce pressure o…

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers at the University of Tulsa are studying Exposure, Relaxation, and Rescripting Therapy (ERRT), a brief treatment for frequent trauma-related nightmares. The trial enrolls about 90 adults who have experienced trauma and have roughly one nightmare per week. Participants …

Researchers are comparing a powered prosthetic knee with a standard microprocessor-controlled knee in people who have an above-knee amputation and are highly active. Participants will use each knee for three months while wearing an activity monitor to track daily steps. The study…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

This study tests a hydrocolloid dressing (a special bandage) applied right after oculofacial surgery to see if it can replace antibiotic ointment. Twenty adults who have had Mohs surgery or other facial reconstruction will wear the dressing for one week. The goal is to simplify p…

This study compares two types of wound dressings—chlorhexidine-impregnated gauze and povidone-iodine dressing—to see which one better prevents infection and speeds up healing in people with fresh, clean-contaminated wounds from an injury. About 176 adults aged 18 to 65 will take …

Researchers are testing a biodegradable nasal dressing called OCEAN that releases the steroid mometasone furoate. The dressing is placed in the nose after endoscopic sinus surgery in adults with chronic rhinosinusitis, with or without nasal polyps. The trial checks safety by coun…

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

This trial tests whether replacing part of a standard rehabilitation session with Wii Fit or Pilates exercises improves walking, balance, and leg strength in adults with healed lower-limb burns. Participants receive 60-minute supervised sessions three times a week for 12 weeks, s…

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

This study compares two types of nerve blocks—SFIB and PENG—to see which one controls pain better after hip replacement surgery. Sixty patients will be randomly assigned to receive one of the blocks. The main goal is to measure how much morphine they need in the first 24 hours af…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

Researchers are studying whether TENS, a device that sends mild electrical pulses through the skin, can lower pain and reduce the need for painkillers after total hip replacement. The trial enrolls 60 adults who have had hip replacement surgery and do not have a pacemaker, heart …

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

Researchers are testing whether short, repeated sessions of mild low oxygen (mild intermittent hypoxia) can strengthen upper airway muscles and improve sleep apnea treatment. Adults with newly diagnosed obstructive sleep apnea and prehypertension or stage 1 hypertension, includin…

Children with spinal cord injury often struggle to sit upright because their trunk muscles are paralyzed. Researchers are testing a device that sends electrical pulses through the skin to the spinal cord, called transcutaneous spinal stimulation, to see if it can improve sitting …

Researchers at the University of Louisville are testing whether combining activity-based locomotor training with non-invasive spinal stimulation can improve sitting posture and trunk control in children with chronic spinal cord injuries. The trial enrolls 14 children, ages 3 to 1…

Researchers are comparing two 9-week group classes for veterans who have a history of mild traumatic brain injury and post-traumatic stress disorder. One class teaches mindfulness, meditation, and yoga; the other teaches how the brain works and recovers after injury. The study me…

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

This study looks at whether applying heat and giving abdominal massage soon after hip fracture surgery can improve bowel function and mental well-being. About 75 adults who had hip surgery and haven't had a bowel movement yet will receive these treatments twice a day for three da…

This study tested two materials—concentrated growth factor and collagen fleece—to see if they help the roof of the mouth heal better after gum graft surgery. 38 healthy adults took part, and the materials were placed on the wound and covered with a dressing. The goal was to reduc…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

This study tests whether adding a structured exercise program to standard ergonomics training can reduce work-related pain and improve quality of life in female dairy farmers. Sixty women who have been farming for at least 5 years will be split into two groups: one gets only ergo…

This study looked at whether a Quadro-Iliac nerve block can reduce pain after hip surgery. Researchers reviewed 60 patients who had hip surgery, comparing those who got the block plus standard pain relief to those who only used standard pain relief. They measured opioid use, pain…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests two additional therapies for people recovering from a broken wrist (distal radius fracture) treated with surgery. One therapy uses gentle manual movements (Mulligan mobilisation), and the other uses mental imagery exercises (graded motor imagery) to retrain the b…

This trial tests the Nike Sport Sole, an accessory that attaches to the Cheetah Xceed running prosthetic foot. The sole comes in two versions: a traction sole for general running and a spike pad for track use. Researchers will have three people with below-knee amputations use the…

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This study tests a new two-sided pad (Debrisoft Duo) for cleaning wounds by removing dead tissue. About 104 adults with various wound types (like diabetic ulcers or burns) will be randomly assigned to the new pad or the current one-sided pad. The main goal is to see if the new pa…

This study tests whether high doses of branched chain amino acids (BCAAs), a type of supplement, can help people aged 11 to 23 recover from a concussion more quickly. Participants receive either a BCAA drink or a placebo for 28 days. The main goal is to see if more people in the …

Researchers are testing whether a mobile and web-based healing program can reduce trauma and stress in university students who lived through earthquakes. The program combines film therapy, laughter yoga, stress coping training, progressive relaxation, grief education, expressive …

This study looked at whether virtual reality glasses or simple game cards can help children aged 5 to 10 feel less fear, anxiety, and pain during wound care. Ninety kids were split into three groups: standard care, care with game cards, or care with virtual reality. Researchers m…

Researchers at Lyon University Hospital are testing whether adding sophrology, a relaxation technique, and art therapy to standard rehabilitation can improve quality of life for people recovering from hand or upper limb surgery. The trial will enroll 31 adults treated in the hand…

This trial tests whether giving spinal anesthesia in small, divided doses through a tiny tube keeps blood pressure more stable than a single standard dose in frail patients over 60 with hip fractures. Researchers will monitor blood pressure during the two-hour surgery and track p…

This study tests a new nerve block called FRONT for pain relief after hip nail surgery in adults aged 60 and older. The block uses one needle to target two nerves, aiming to reduce pain while preserving leg movement so patients can get up and walk sooner. 60 participants will be …

This study tests whether watching a custom 360-degree virtual reality video during dressing changes can lower pain, anxiety, and the need for opioid painkillers in adults recovering from burn surgery. Eighty participants will wear VR headsets while their bandages are changed and …

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This trial tests whether giving a steroid injection just before surgery for a broken leg can reduce swelling and pain compared to a placebo. Adults with certain leg fractures who need surgery within 72 hours are randomly assigned to receive either the steroid or a saline injectio…

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil …

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests whether a six-week program of eye exercises delivered through virtual reality can help adults aged 18 to 42 who have vision problems after a concussion. Participants are randomly assigned to either the eye exercise program or usual care (education and symptom man…

This study tested whether adding photobiomodulation (light therapy) to standard physical therapy helps military trainees with leg stress fractures heal faster. 105 participants received either real or sham light therapy for up to 6 weeks, and researchers tracked how quickly they …

This study compares two approaches to pain control in elderly patients having hip fracture surgery: a standard femoral nerve block versus a femoral block plus an additional PENG block. The goal is to see if the combination reduces pain during spinal anesthesia positioning and low…

This study compares two ways of numbing the arm for wrist fracture surgery. One group receives a standard axillary block with a long-lasting anesthetic, while the other gets a short-acting axillary block plus separate long-acting blocks at the elbow for the median and radial nerv…

This pilot study tested a new therapy called Psychological Cognitive Reprocessing Procedure (P-CRP) in 43 adults with trauma and grief. Unlike standard treatments, P-CRP starts by silently repeating a word tied to a negative belief while tapping the shoulders, letting the mind pr…

This study tests whether virtual reality (VR) exercises can improve cognitive functions like attention and problem-solving in people with severe acquired brain injury. Twenty-eight participants will be randomly assigned to either VR-based cognitive training or traditional paper-a…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tested a home-based program to help aging veterans with a history of traumatic brain injury (TBI) improve their thinking skills, such as attention and planning. Twenty-nine veterans aged 65 and older used telehealth technology to complete cognitive exercises from home.…

This study looked at whether e-health tools—like a phone call from a specialist or a self-report app—can help manage pain and anxiety after a breast biopsy. About 193 women took part. The goal was to see if these check-ins lead to less pain and better well-being compared to stand…

This study tested whether adding a nerve block catheter (erector spinae plane) to standard painkillers helps people with chest trauma breathe better and have less pain. Forty adults with broken ribs and poor lung function were randomly assigned to get the catheter plus usual care…

This study tested a 20-minute neck-strengthening program in 50 amateur rugby players to see if it could speed up their neck muscle reactions to head impacts. The program used isometric contractions and stroboscopic glasses to improve visual processing and reflex force. Researcher…

This study tested three different treatment approaches for teens aged 13-19 who had a concussion within the past three weeks and were still experiencing moderate to severe symptoms like headaches, dizziness, and neck pain. The goal was to see if early, symptom-specific treatments…

This study tested a new way to numb only the front part of the foot for surgery, leaving the heel sensation intact. The goal was to see if this approach could provide good pain relief while allowing patients to walk earlier. Twenty-seven adults having foot surgery received a targ…

This study tested whether a procedure called vertebroplasty (injecting cement into a broken spine bone) relieves pain better than a sham (fake) procedure in people with osteoporosis. 52 adults aged 50 and older with recent spine fractures took part. The main goal was to measure p…

This study tested whether briefly restricting blood flow to the leg during physical therapy could help people regain strength and muscle after a broken femur (thigh bone). 219 adults aged 18-55 with a closed femur fracture took part. The approach uses a special tourniquet system …

This study tested whether puncturing the RP6 acupuncture point during the pushing phase of labor could reduce perineal tears and increase the chance of an intact perineum after childbirth. 350 women who had never given birth vaginally were randomly assigned to receive either real…

This study looked at two types of nerve blocks—fascia iliaca block and femoral nerve block—to see which one works better for pain control in people having hip fracture surgery. 80 adults were randomly assigned to receive one of the two blocks before spinal anesthesia. The main go…

This study tested whether using bandages printed with cartoon characters helps children feel less fear, stress, and pain during burn dressing changes. 42 children aged 6-11 with second-degree burns were randomly assigned to get either cartoon or plain bandages. The goal was to se…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested whether a virtual rehabilitation program called VIVA is feasible for people with spine fractures caused by osteoporosis. The program includes weekly online sessions to help reduce pain and improve movement and quality of life. The study involved 34 participants …

This study tested a procedure called cryoneurolysis, which uses a device to freeze nerves near broken ribs to block pain. It involved 43 adults aged 18-64 with rib fractures who were not candidates for surgery. The goal was to see if this approach could lower pain scores and redu…

This study looked at whether a special nerve block called PENG can help people who have partial hip replacement surgery feel less pain and need fewer painkillers. 48 adults having this surgery were split into two groups: one got the nerve block plus usual care, the other got usua…

This study tested whether a nerve block (lumbar erector spinae plane block) guided by ultrasound works as well as spinal anesthesia for hip and upper thigh surgery. Sixty-six adults received either the nerve block or spinal anesthesia, and researchers measured how long it took be…

This study tested whether placing platelet-rich fibrin (PRF) made from the patient's own blood or an absorbable collagen sponge into the socket after wisdom tooth removal improves healing. Twenty-nine healthy adults with impacted lower wisdom teeth on both sides took part. Each s…

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study tested whether resistance training with a blood flow restriction (venous occlusion) helps people regain hand strength and function after a burn injury. Thirty-four patients with healed hand burns did either standard rehab or the same exercises with a cuff limiting bloo…

This study tested whether adding TECAR therapy (a device that uses electrical currents) to standard exercises improves balance, pain, and daily function after an acute ankle sprain. 42 adults with grade I or II sprains were split into two groups: one did exercises alone, the othe…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study tested a new device called Intensive Neurowave Emotional Stimulation (INES) in 40 people with disorders of consciousness after severe brain injury. The experimental group received multisensory stimulation with emotionally meaningful audio-visual content, while the cont…

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested a special nursing approach, called the Tidal Model, to help caregivers of people with traumatic brain injury. 18 caregivers took part and the program aimed to reduce their anxiety, depression, and burnout. The approach focused on understanding each caregiver's p…

This study tested a procedure called cryoneurolysis, which uses a cold probe to freeze nerves around broken ribs, in 127 elderly patients. The goal was to reduce pain and the need for strong narcotics, helping patients recover faster. Researchers measured pain scores at discharge…

This study tested whether a nerve block called an erector spinae plane (ESP) block is practical to use in trauma patients with broken ribs. It included 27 adults with rib fractures and moderate to severe pain. The goal was to see if a larger trial is possible, not to prove the bl…

This pilot study tested two ways to manage pain in patients aged 70 and older who had a hip fracture and were waiting for surgery. One method used a continuous pulling technique on the skin, and the other used a pillow placed between the legs. The goal was to see which approach c…

This study tested a computer-controlled method of giving propofol sedation to 45 adults in the emergency department. The goal was to find the right brain concentration needed for deep sedation during painful procedures like fixing a broken bone or putting a dislocated joint back …

This study looked at whether a home-based rehabilitation program helps older adults (65+) recover walking ability after hip fracture surgery. Instead of staying in the hospital, participants received hospital-level care at home, including physical therapy and wound care. The goal…

This study tested a gel made from cross-linked hyaluronic acid to see if it helps gums heal after a gum graft. Twenty healthy adults took part. Half received the gel on the wound, while the other half did not. Participants rated their pain and healing over two weeks, with checkup…

This study looked at whether different exercise programs could help children aged 10 to 17 who had severe burns on their legs. 84 children were split into three groups: balance training, jump-based (plyometric) training, or a mix of both. They exercised three times a week for eig…

This study looked at whether acupuncture can reduce dry mouth (xerostomia) caused by radiation therapy in people with head and neck cancer. A total of 258 participants were randomly assigned to receive acupuncture or usual care. The main goal was to see if acupuncture improved dr…

This study tested whether a single osteopathic session in the emergency department can improve recovery from a mild to moderate ankle sprain. Fifty adults with recent sprains were split into two groups: one got standard medical care, the other got osteopathic treatment. Researche…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury. One program used movement to music, the other standard exercises. Researchers measured physical activity levels and pain to see which approach worked better.

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested a personalized magnetic brain stimulation therapy called MeRT for people with PTSD. 158 adults received either real or sham treatment. The goal was to see if MeRT could safely reduce PTSD symptoms. The approach tailors the stimulation to each person's brain wave…

This study looked at how well Global D implants work for orthognathic (jaw) surgery and whether they improve patients' quality of life. 198 people who had their first jaw surgery received these implants. Researchers measured quality of life before and after surgery using a specia…

This study tested a mobile app called Back2Play that guides youth through step-by-step return to school and physical activity after a concussion. Researchers wanted to see if using the app reduces symptoms, speeds up recovery, and lowers the chance of getting another concussion. …

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested a high-intensity interval training (HIIT) walking program for people recovering from a broken thigh or shin bone. 66 adults aged 18-50 who had surgery for their fracture took part. The goal was to see if this type of exercise could improve their physical functio…

This study tested whether a mattress that gives off low-level electromagnetic pulses (BEMER therapy) can improve sleep, readiness to play, and injury recovery in elite female football players. Sixty athletes used either the active mattress or a sham (fake) mattress for 8 minutes …

This study tested whether taking branched-chain amino acids (BCAAs) can improve sleep and thinking in veterans who have had a mild traumatic brain injury. 160 veterans were randomly assigned to receive different doses of BCAAs or a placebo for 12 weeks. The main goal was to see i…

This study looked at whether different types of physical exercise can help adults recover from a mild traumatic brain injury (concussion). 37 adults who had a concussion within the past year took part in a 3-month program of either balance or aerobic exercises. Researchers measur…

This study tested a program called ABC ANSWERS for veterans with Alzheimer's disease or traumatic brain injury and their informal caregivers (family or friends). The program added extra support and education to regular primary care. Researchers measured changes in quality of life…

This study looked at two different surgical methods for replacing the shoulder joint in people over 65 who had a severe shoulder fracture. The goal was to see which approach leads to better shoulder function, safety, and quality of life. 90 participants were randomly assigned to …

This study looked at 80 adults with a broken upper arm bone who needed surgery to place a metal nail inside the bone. Researchers compared the usual method (going through the rotator cuff) with a newer method (going through a gap called the rotator interval). The goal was to see …

This study tested whether an online program combining cognitive exercises and mindfulness training could help soldiers and veterans with mild traumatic brain injury (TBI) improve their memory, attention, and thinking speed. Twenty-three participants used either a specialized brai…

This study tested whether a special numbing mixture called WALANT could reduce pain during central venous catheter (CVC) insertion better than standard lidocaine. Sixty-four trauma or dialysis patients were randomly assigned to receive either WALANT or lidocaine before the proced…

This study tested whether virtual reality (VR) exercises can improve memory and thinking in adults aged 65 and older who had a mild traumatic brain injury. Thirty participants used VR at home for six weeks. The goal was to see if VR could help with attention, memory, and visual s…

This study tested whether adding ear acupuncture (auricular thumbtack needle therapy) to standard care and nerve stimulation could help people with traumatic brain injury regain consciousness. Sixty patients with a Glasgow Coma Scale score of 4-8 were randomly assigned to receive…

This study tested whether a program called Equine Assisted Learning (EAL) can reduce trauma symptoms in public safety personnel like police, firefighters, and paramedics. 40 participants from Saskatchewan took part in 16 sessions of unmounted activities with horses, guided by men…

This study tested whether a PENG nerve block—a targeted injection of anesthetic around the hip—can reduce pain and the need for morphine in adults with hip fractures in the emergency department. 36 patients were randomly assigned to receive either the block plus standard care or …

This study tested a special talking therapy (values-based cognitive behavioral therapy) for 6 adults with spinal cord injury from road accidents. The goal was to see if it helps reduce daily pain and improve living according to personal values. Participants attended 10 therapy se…

This study tested a program to help older cancer patients get stronger before and after surgery. 148 patients aged 70+ (or 60+ with other health issues) took part. The program included exercise, nutrition advice, and education to reduce complications and improve recovery.

This completed study tested two different anesthetic drugs—dexmedetomidine and sufentanil—in 28 people having surgery for traumatic brain injury. The goal was to see which one keeps the brain's oxygen levels more stable during and after the operation. Researchers measured oxygen …

This study tested whether starting gentle leg cycling in bed within 48 hours after spinal surgery is safe and doable for people with severe spinal cord injuries. Forty-five adults took part, cycling for 30 minutes daily for two weeks. Researchers checked for safety, how many sess…

This study tested a program called IVY for middle school students who have been bullied. The goal was to help them feel less distressed and learn skills to protect themselves and cope. 48 students participated and the program focused on building knowledge and confidence.

This study tested a 12-session telemedicine support group for people with brain injuries and their caregivers. The group taught coping skills and emotional support to improve confidence and well-being. Only 13 people took part, so the results are preliminary but suggest remote su…

This study tested a free service called Resource Facilitation for people with traumatic brain injury (TBI). Participants worked one-on-one with a specialist to set goals and connect with services. The goal was to see if this support improves quality of life and reduces disability…

This study tested a 12-week telemedicine coping skills group for brain injury survivors and their caregivers. Participants learned strategies to manage stress, depression, and communication challenges. The goal was to see if a virtual format could be as effective as in-person ses…

This study tested whether using a device that electrically stimulates the abdominal muscles can help people with spinal cord injury manage their bowel movements more quickly and comfortably. 36 adults with injuries at or above T12 were randomly assigned to receive real or low-dos…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones who came to the emergency room in severe pain. Researchers wanted to see if giving paracetamol (Tylenol) or ibuprofen (Advil) along with morphine worked better than morphine alone. They measured pain leve…

This study tested whether adding a sedative (midazolam) to standard morphine painkiller helps children with arm fractures feel less pain. Sixty children aged 5 to 16 were split into two groups: one got morphine plus midazolam, the other got morphine plus a placebo. Researchers me…

This study tested whether hypnosis, with MEOPA (a pain-relieving gas) available if needed, works as well as MEOPA alone for controlling pain in children getting stitches. Sixty children in the emergency department were randomly assigned to one of two groups. The goal was to see i…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. Th…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested two types of wound dressings—Lomatuell Pro and UrgoTul—on 183 people with acute wounds like cuts, scrapes, or minor burns. The main goal was to see which dressing caused less pain when removed. Patients rated their pain during the first dressing change, and the …

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This study tested a personalized treatment plan for people with mild traumatic brain injury (concussion) that targets specific symptoms like anxiety, headaches, vision problems, and sleep issues. 169 adults with recent concussions were assigned to either the targeted treatment or…

This study tested whether playing an immersive video game called Bandit the Dolphin could improve thinking and movement in adults who had a traumatic brain injury years ago. The game involves moving your arms to control a dolphin in an ocean environment, combining physical and me…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study looked at two methods of injecting bone cement into fractured vertebrae in elderly patients with osteoporosis. 196 patients were randomly assigned to receive either a one-sided or two-sided injection. The goal was to see which approach better reduces pain and improves …

This study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…

This study tested whether adding a nerve block to a standard hematoma block reduces pain better during wrist fracture realignment. 180 adults with displaced wrist fractures were randomly assigned to receive either a hematoma block alone or a hematoma block plus a median nerve blo…

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This study tested a 10-session art therapy program for adults with trauma-related symptoms who have difficulty with traditional talk therapy. 38 participants made artwork to process memories and emotions. Researchers measured changes in emotional expression, self-esteem, and resi…

Researchers at Pamukkale University are studying overhead athletes, such as throwers and swimmers, to see whether differences between the dominant and non-dominant arm relate to injury and performance. About 58 athletes aged 15 and older who train and compete regularly take part.…

This study looks back at 8000 trauma patients with spleen injuries to figure out the best treatment approach. Researchers want to compare surgery (splenectomy) with a less invasive procedure (embolisation) and see what works best for different injury grades. The goal is to improv…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study surveys healthcare workers in the Hampshire and Isle of Wight region to understand how they care for older adults (65+) who take blood thinners and have fallen, possibly hitting their head. The goal is to map current services, identify challenges, and find ways to redu…

This study looked at whether a simple score called mREMS can predict how trauma patients will do in a hospital in Baghdad. Researchers checked 292 patients with road traffic injuries. They want to see if the score can help doctors in places with limited resources make better deci…

This study looks at two ways to give oxygen to people with acute brain injury after their breathing tube is removed. One method uses a high-flow nasal cannula, which delivers warm, moist oxygen through the nose. The other is conventional oxygen therapy, like a face mask or nasal …

This study looks back at the records of adults who had surgery for gunshot wounds to the abdomen or chest and abdomen. Researchers compare patients with obesity, defined by a body mass index of 30 or higher, to those without obesity. They track complications, time in the intensiv…

This study looks at 406 patients with acute brain injury who need a breathing machine. Doctors often struggle to know when it's safe to remove the tube, and many patients fail. The goal is to find clues that predict successful weaning, so patients can avoid unnecessary procedures…

Researchers are observing older adults, aged 65 and up, who arrive at the hospital with a brain injury. They will record blood levels of sodium, potassium, calcium, and other electrolytes over five days, along with measures like the Glasgow Coma Scale. The study compares patients…

Researchers are testing whether a type of non-invasive brain stimulation, called intermittent theta burst stimulation, can change how the brain controls hand muscles. The study includes adults with and without spinal cord injuries to compare brain-muscle connections. By measuring…

This study tests whether a computer algorithm can predict neurological decline in people who arrive at the hospital within 6 hours of a traumatic brain injury. Researchers will collect vital sign data and use machine learning to see if it can forecast worsening brain function, su…

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

Researchers are studying whether a muscle-released hormone called irisin is linked to bone strength in people with spinal cord injury. They will compare irisin levels and bone density between individuals with spinal cord injury and healthy controls. Participants will also do one …

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This study looks back at the records of 461 women in Brazil who received a short, high-dose radiation schedule after breast cancer surgery. The schedule, called extreme hypofractionation, delivers 5 doses of 5.2 Gy instead of many smaller doses. Researchers want to see how well t…

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study compares virtual reality (VR) training to mannequin training for teaching medical students how to manage airway injuries. Forty medical students will be randomly assigned to learn using VR or a mannequin, then tested a week later. The goal is to see if VR can provide e…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This observational study tests whether a bispectral index (BIS) monitor, which tracks brain activity, can reliably measure how deeply sedated patients with traumatic brain injury are in the intensive care unit. Researchers will compare BIS readings with other measures like pressu…

This trial investigates how the body handles sevoflurane, an inhaled anesthetic used for short-term sedation, in burn patients in the intensive care unit (ICU). It compares drug levels in burn patients with those in other ICU patients to see if dosing needs adjustment. The study …

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study investigates how often adults remember events during procedural sedation with propofol in the emergency department, specifically for fracture or joint dislocation reduction. About 250 participants will be asked a questionnaire the day after sedation to check for any re…

This observational study looks at how people with spinal cord injuries maintain balance while performing a stationary wheelchair wheelie. Participants will be asked to hold a wheelie for at least 20 seconds while sensors track their body movements and balance. The goal is to unde…

This study explores whether an enhanced rehabilitation program (ERP) is practical for people recovering from major trauma, such as severe leg injuries or multiple injuries. Participants receive at least two sessions per week of therapies like exercise, manual therapy, and cogniti…

This study follows 3,000 people who received stitches for traumatic wounds in an emergency department. Researchers track how the wounds heal and look for factors that lead to complications like infection or stitches coming apart. The goal is to identify what makes some wounds hea…

This study looks at whether water polo players have different shoulder flexibility, strength, and core stability compared to non-players. Researchers measure shoulder rotation, muscle tightness, and trunk endurance in both groups. The goal is to understand what might lead to shou…

This study looks back at medical records of over 1,000 people hospitalized for burns to see which of three scoring systems—ABSI, Revised Baux, or Modified Ryan—best predicts whether a patient will survive. The goal is to find the most accurate tool for doctors to use when making …

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This completed study tested a standard way to select seriously brain-injured patients who might become brain dead within 48 hours. Researchers tracked 83 patients in intensive care to see how many progressed to brain death. The goal was to improve the process for organ donation c…

This study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This completed study tested whether brain wave recordings (event-related potentials) can detect cognitive processing in people with brain injuries, including those with altered consciousness. Researchers compared 320 patients and healthy adults using high-density EEG. The goal wa…

This study looked back at 134 patients under 75 who had a partial hip replacement after a broken hip. The goal was to see how often the hip socket wears down over time and how often that leads to a second surgery. Researchers also checked if a common way to measure socket erosion…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study investigates whether a specific ultrasound measurement—called maximal diaphragm thickening fraction—can accurately assess diaphragm function in patients who are on mechanical ventilation. Researchers will compare this ultrasound technique to a standard method (phrenic …

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study looked at whether the ratio of urea to creatinine in urine can help identify malnutrition in intensive care patients with brain injury. Malnutrition is common in the ICU and raises the risk of infections. Researchers measured this ratio in 309 adults and tracked six ty…

This study observed over 1,600 adults in French emergency rooms to understand how patients are managed in the resuscitation area and whether being admitted directly to that area versus later affects their need for intensive care within 24 hours. Researchers recorded patient detai…

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…

This study looked at blood and saliva samples from 260 people, including those with traumatic brain injuries, to find protein markers that appear before dangerous pressure builds up inside the skull. The goal is to see if a simple blood test could warn doctors early. No treatment…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if thi…

This study looked at whether patients who had heart surgery can safely and effectively collect swabs from their own chest wounds at home. 43 adults were observed via video call as they swabbed themselves, then sent the samples to a lab. The goal was to see if this method is accep…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked at how heading a soccer ball changes the brain and whether wearing a mouthguard makes a difference. Twenty-one male soccer players did 10 headers in two sessions—once with a mouthguard and once without. Before and after, they had brain scans, cognitive tests, an…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This completed study looked at 60 adults having leg surgery with a tourniquet to see if spinal or general anesthesia better maintains blood flow in the leg. Researchers used a light-based sensor to measure tissue oxygen levels. The goal was to understand which method might reduce…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study collected X-ray images from 32 head and neck cancer patients during their radiation therapy sessions. The goal was to measure how much the head moves or changes shape between treatments. Researchers also used the images to create realistic artificial X-rays for future …

This study looked at whether resetting a broken wrist in the emergency room helps reduce pain while waiting for surgery. 147 adults with a displaced distal radius fracture took part. Researchers measured daily pain and hand function to see if the reset made a difference.

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked at whether robotic gait training helps people with spinal cord injury walk better compared to standard walking therapy. 115 patients in inpatient rehab took part. The goal was to measure improvements in walking ability and speed.

This study examined bacteria in severe leg wounds of 646 adults (ages 18-64) with open tibia fractures or traumatic amputations. Researchers took samples at the time of wound closure to see if certain bacteria led to deep infections within 30 days to one year. The goal was to bet…

This study tested whether a special 3D X-ray done in the operating room can replace standard CT scans after repairing an abdominal aortic aneurysm. 427 patients were randomly assigned to either the new 3D scan or the usual approach. The goal was to see if the new method reduces r…

This study looked at 161 older adults who had hip fracture or joint replacement surgery. Researchers checked if medications with a high 'atropine load' (a measure of anticholinergic effect) were linked to postoperative confusion. They used the Confusion Assessment Method daily an…

This completed study looked at hand and wrist injuries in professional hockey players in the Swedish Hockey League over three seasons. Researchers analyzed injury data from about 2,300 games to understand what types of injuries happen, when they occur, and which players are most …

This study looked back at the medical records of 150 adults who had surgery for facial fractures using the Stryker Universal CMF System. The goal was to confirm that the system safely and effectively holds broken facial bones in place. Researchers checked whether any patients nee…

This study looked at 165 trauma patients to see how often they had low blood oxygen (hypoxemia) during their first 24 hours in the hospital. Researchers used a special finger clip to track oxygen levels and compared daytime vs. nighttime episodes. The goal was to understand when …

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This study looked back at 70 patients who had jaw reconstruction surgery using Stryker's custom-made Surgeon iD plates. The goal was to confirm the plates are safe and work well by checking how many patients needed unplanned follow-up surgery. Researchers also tracked infections …

This study looked at whether tiny molecules in the blood, called microRNAs, can help tell if someone with a mild head injury has actual brain damage visible on a CT scan. Researchers took blood samples from 155 people with mild traumatic brain injury and compared those with and w…

This study looked back at 170 adults with chronic neck pain from whiplash injuries to compare two treatments: radiofrequency (a nerve-blocking procedure) and neck fusion surgery. Researchers reviewed medical records from a 20-year period to see which treatment provided better pai…

This study involved over 22,000 children who experienced blunt trauma (like car crashes or falls) to develop a tool that helps doctors decide which kids truly need neck immobilization and imaging. The goal is to avoid unnecessary X-rays and CT scans, which expose children to radi…

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This study tested whether a gentle electrical stimulation on the ear (taVNS) can improve how the heart and nervous system respond during exercise in people with chronic spinal cord injury. 35 adults completed two exercise sessions—one with real stimulation and one with a sham (fa…

This completed study looked at 86 patients who had a fracture possibly due to weak bones (osteoporosis). Researchers wanted to see if the calcium supplements patients were prescribed matched what they actually got from food. Many patients get calcium pills even if their diet alre…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study looked at 80 frail older adults who had hip surgery after a fall. Researchers took small muscle samples to measure fat, protein, and gene activity. The goal was to understand whether muscle amount or muscle function matters more for recovery. This is a knowledge-gather…

This study looked at whether a portable brain scanner called fNIRS can safely and effectively measure brain activity in people with chronic traumatic brain injury while they walk on a treadmill with virtual reality. Eight participants completed the session, and researchers checke…

This study tested a simple tool to help family doctors better manage mental health problems after a mild traumatic brain injury (concussion). Over 500 adults who visited an emergency department were enrolled. Doctors received a letter with their patient's mental health screening …

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study looked at 42 people who had surgery for multiple torn knee ligaments between 2000 and 2019. Researchers measured knee function and symptoms using standard questionnaires. The goal was to understand how well surgery works for these serious injuries, which can cause long…

This study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…

This study looked at 77 adults with a specific type of knee fracture (Schatzker IV) to see if MRI and CT scans could predict which fractures also involve a dislocation. Researchers compared imaging features between those with and without dislocation. The goal was to help surgeons…

This study tested whether a special type of MRI (called DBSI) can predict how well people recover after surgery for a compressed spinal cord. 71 patients with cervical spondylotic myelopathy had this MRI before surgery and again 2 years later. Researchers looked for imaging marke…

This study tested a program called TEaM to improve how doctors and schools support children after a mild traumatic brain injury (concussion). The program included training for doctors and tools to help them communicate with schools and families. Researchers enrolled 101 children …

This small study tested whether it is safe and practical to use two devices together in people with recent spinal cord injury. Eight participants received both a mild electrical stimulator placed on the back and leg, and a low-level laser. The main goal was to see if the equipmen…

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study looked at how the antifungal medicine caspofungin is processed in the bodies of adults with serious burns. The goal was to find the best dose, since burns can change how drugs work. Only 2 people took part, so the results are very limited.

This study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …

This study looked at how walking with a robot (Lokomat) helps people with spinal cord injuries recover movement. Ten patients were assessed before, during, and after training, plus one month later. The goal was to understand how gait improves over time, not to test a new drug or …

This study looked for proteins in the blood that could tell doctors early on whether a broken arm bone is healing well or might lead to a nonunion (where the bone doesn't heal). Researchers studied 45 adults with simple humerus fractures treated without surgery. They checked bloo…

This study reviewed 148 patients who had thigh bone or hip replacement-related fracture surgery using metal wires (cerclage) to hold bone pieces together. Researchers found that using more wires was linked to a higher chance of deep infections and prolonged wound drainage. The fi…

This study looked at how blood sugar levels relate to sugar levels in the brain of 14 seriously ill patients with acute brain injury. Researchers used special monitoring tools to measure brain sugar and oxygen. The goal was to better understand this relationship and create a math…

This study explored whether getting an ultrasound a few days after an ankle sprain leads to better recovery after 3 months. Researchers observed 13 patients who had a follow-up visit between day 3 and day 6 after injury. The goal was to see if the ultrasound helped doctors better…

This study tested a digital platform that helps hospital staff quickly identify patients who are bleeding, so they can be asked to join future research studies. About 40 adults admitted to Oxford University Hospitals took part. The goal was to see if the platform could correctly …

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study looked at swallowing problems in 34 patients with severe traumatic brain injury who are minimally conscious. Researchers used a special X-ray test called videofluoroscopy to see how swallowing works. The goal was to better understand these swallowing disorders, which c…

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study tested whether the sedative dexmedetomidine can lower C-reactive protein (CRP), a marker of inflammation, in 25 adults with traumatic brain injury undergoing emergency or planned skull surgery. Patients received either dexmedetomidine or a standard sedative during surg…

This study tested whether brief sessions of breathing low-oxygen air are safe for people who have had a traumatic brain injury (TBI). Twelve adults with mild to moderate TBI received up to four sessions of acute intermittent hypoxia, where oxygen levels were briefly lowered. Rese…

Researchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…

This study tested a new method called continuous anterior chest compression (CACC) to help people with severe lung injury (ARDS) breathe better. Twenty adults on ventilators were studied to see if pressing on the chest improved lung function compared to lying on the stomach. The …

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This study explored whether personality type (A or B) and stress levels differ between people with type 2 diabetes who have foot wounds and those who do not. Researchers used questionnaires to measure personality, stress, depression, and quality of life in 66 participants. The go…

This study analyzed blood and other samples from 106 adults with recent spinal cord injuries to find molecules linked to better recovery. Researchers measured changes in these molecules before and after rehabilitation and one year after injury. The goal is to identify biological …

This study tested whether custom carbon fiber braces can reduce harmful forces on the ankle joint after a fracture, which may lower the risk of developing arthritis. Twenty-two adults with healed ankle fractures walked with and without different brace designs while researchers me…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This completed study looked at 25 people who had COVID-19 but were not hospitalized, yet still felt short of breath and tired. Researchers measured their diaphragm strength using advanced breathing tests and ultrasound. The goal was to see if diaphragm weakness is a hidden cause …

This study followed 912 men and women over 60 in France who were hospitalized for severe osteoporotic fractures. Researchers tracked how many had another severe fracture within 2 and 5 years, and how many died during that time. The goal was to better understand the long-term risk…

This completed study looked at breathing muscle function in 50 people who were hospitalized for COVID-19. Half had been on a ventilator, half only needed extra oxygen. Researchers used advanced tests to measure diaphragm strength and movement. The goal was to understand why many …

This study reviewed records of 610 older adults (over 65) on blood thinners who had hip fracture surgery. Researchers wanted to see how long surgery was delayed to avoid bleeding risks and whether that delay affected survival. The goal is to find the safest approach to schedule s…

This study looked at 94 adults with a recent spinal cord injury to see if keeping their blood pressure at a higher or lower target helped them heal better. Participants were split into two groups: one with a standard blood pressure goal and one with a higher goal, maintained for …

This study looked at how the brain controls eye movements in people aged 11 to 35 who had a concussion 1 to 6 months ago and still have trouble focusing their eyes (convergence insufficiency). Researchers compared these participants to others with eye focusing problems not caused…

This completed study from Versailles Hospital looked back at 200 medical reports of adults with skin injuries like cuts, scrapes, burns, and leg ulcers. The goal was to see how well pain was controlled during treatment. Researchers also interviewed some patients and staff to chec…

This study looked at how well the Chimaera intramedullary nail works in elderly patients with hip fractures. Researchers tracked 206 people aged 65 and older who had surgery with this device. The main goal was to see how many needed a second surgery due to problems, and they also…

This study looked at 250 people who had a severe type of heart attack involving bleeding into the heart muscle. Researchers tested whether a measurement called the wall strain index ratio, taken from a heart MRI, could identify areas of the heart at risk of tearing (rupture). The…

This study measures normal ankle function in 96 healthy military personnel using the Ankle-Go test, which combines physical exercises and questionnaires. The goal is to establish reference values for soldiers, who have different physical demands than civilians. Results will help …

This study tested whether a therapy called 'illusory movements' (where patients imagine or sense movement without actually moving) could help reduce muscle breakdown in people with severe burns covering 20% or more of their body. Researchers measured energy use, muscle loss, and …

This study tested whether an online course can effectively train laypeople in sub-Saharan Africa to provide emergency first aid for trauma injuries. Over 650 commercial drivers in Nigeria, Sierra Leone, Uganda, and Kenya took either an in-person or virtual half-day training cover…

This study looked at 154 elderly patients (70 years or older) having hip fracture surgery. It compared a special type of spinal anesthesia (low-dose hypobaric lateral spinal anesthesia) with general anesthesia to see which one keeps blood pressure more stable during surgery. The …

This study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…

This study followed 88 adults with moderate to severe traumatic brain injury for up to 18 months. Researchers used MRI scans and hormone tests to see if hormone deficiencies after injury are linked to lower quality of life. The goal was to better understand these connections, not…

This completed study looked at how the immune system is weakened after septic shock, severe trauma, burns, or major surgery. Researchers took blood samples from 552 patients and healthy volunteers to measure immune function. The goal was to find better ways to predict and manage …

This study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…

This study looked at 108 healthy sports science students to see if past leg injuries leave lasting changes in walking and running patterns. Participants wore small sensors on their legs while walking and running, and filled out questionnaires about their injury history. The goal …

This study looked back at data from 50 patients with severe brain injuries (from trauma or bleeding) who were treated in the ICU. Researchers analyzed brain blood flow, oxygen levels, and scans to understand how treatments affect the brain and body. The goal is to develop more pe…

This study tested a computer program called ACE that helps nurses decide which products to use for treating chronic wounds. Researchers compared outcomes when nurses used ACE versus their usual approach in 73 patients across 18 clinics. The goal was to see if the tool improves he…

This study looked back at records of 67 children to see if a broken front tooth from an injury could lead to hidden changes in the jaw joint. Researchers used special 3D X-rays (CBCT) to measure joint spaces and check for pain. They found that children with tooth fractures had di…

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This study looked back at records of 120 people admitted to intensive care units in four French hospitals after gunshot wounds. The goal was to describe how often patients died within 28 days and what factors might affect their survival. The study did not test any new treatment, …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This study looked at how people with leg amputations (below or above the knee) balance while walking. Researchers used special pressure-sensing platforms to measure the center of pressure in 130 patients after they finished rehabilitation. The goal was to understand walking asymm…

This study tested whether an artificial intelligence (AI) tool called qER 2.0 EU helps doctors and other health professionals read head CT scans more accurately and quickly. Thirty-three readers, including radiologists, emergency doctors, and radiographers, reviewed 150 scans wit…

This study looked at how powered ankle prostheses change the pressure inside the prosthetic socket and the health of the residual limb in people with below-knee amputations. Six adults who already use a standard prosthetic leg walked on level ground with different types of prosth…

This completed study used MRI scans to see how thinking difficulties appear in the brains of people with spinal cord injury. Fifty-four participants completed cognitive tasks while their brain activity was measured. The goal was to better understand non-motor challenges that ofte…

This study looked at over 8,800 infants under 2 years old who came to the emergency room with a minor head injury. Researchers wanted to see if a special checklist (the PELICAN rule) could help doctors decide when a CT scan is truly needed. The goal is to avoid unnecessary radiat…

This study tested whether sending three text message reminders to adults over 50 who had a low-trauma fracture would encourage them to get a bone density test. The goal was to improve screening for osteoporosis, a condition that weakens bones. Researchers enrolled 97 patients fro…

This study looked at 227 women who had a serious tear during childbirth (obstetrical anal sphincter injury) to find out how many later develop anal incontinence—leaking gas or stool. Researchers collected data on quality of life and incontinence symptoms. The goal is to better un…

This study tested a new classification system called BICEP to better identify and categorize bladder injuries that can happen during prostate surgery. Researchers studied 250 patients undergoing common prostate procedures to see how often injuries occur and how severe they are. T…

This study tested a new 'Mobility Toolkit' to see how well it measures walking recovery in 244 adults aged 18-60 who had surgery for serious leg fractures. Participants used the toolkit during clinic visits over a year. The goal was to see if the toolkit is easy to use and accura…

This study involved 160 elite French athletes from athletics, rugby 7, and bobsleigh. Researchers measured how each athlete runs and the properties of their muscles to create personalized training programs. The goal was to reduce lower-limb muscle injuries while maintaining top s…

This study examined 49 older women with hip fractures to understand why some also break a supportive bone called the lateral wall. Researchers found that lower bone density and lower body weight were linked to these more complex fractures. The goal is to help doctors plan better …

This study looked at whether two substances in the blood, zonulin and interleukin-8, are linked to delirium (sudden confusion) after hip fracture surgery in older adults. Researchers measured these markers before and after surgery in 73 patients over 65. The goal was to see if th…

This study tested whether a small microdialysis catheter placed directly into a bone graft could monitor blood flow and healing after head and neck reconstruction. Thirty-four people having surgery with bone from their hip or leg took part. The goal was to see if the catheter cou…

This study followed 310 people who had elbow surgery with specific implants to see how their arm function improved over two years. Researchers measured disability using a standard questionnaire and tracked any complications or need for additional surgeries. The goal was to gather…

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive neurological diseases like cerebral palsy or brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical records f…

This study looks at how a robotic body-weight support system called FLOAT affects the way people with incomplete spinal cord injury perform everyday tasks like walking, standing up, and climbing stairs. Researchers measure movement and muscle activity with and without the robot's…

This study looked at whether a single session of moderate cycling, done in a lab, with a non-immersive virtual reality screen, or with a full immersive virtual reality headset, could improve thinking speed and multitasking in 24 adults with traumatic brain injury. Participants co…