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Can a common anesthetic be tailored for burn victims?

NCT ID NCT02048683

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial investigates how the body handles sevoflurane, an inhaled anesthetic used for short-term sedation, in burn patients in the intensive care unit (ICU). It compares drug levels in burn patients with those in other ICU patients to see if dosing needs adjustment. The study involves 24 adults on ventilators who require sedation, including those with burns covering 20-50% of their body. By measuring sevoflurane and its byproducts in the blood, researchers aim to refine sedation practices for this vulnerable group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sevoflurane (an inhaled anesthetic used for short-term sedation in the ICU)
What this could lead to
If successful, this could lead to more precise dosing of sevoflurane for sedation in burn patients, improving safety and effectiveness.
What could go wrong
This is a small early-phase study focused on drug levels, not clinical outcomes. Results may not apply broadly, and sevoflurane can have side effects like low blood pressure or breathing issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

24 people

The number who actually took part.

Start date

Dec 2013

Finished

Sep 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients ventilated requiring invasive procedure in ICU * Stable respiratory and hemodynamic conditions * Consent of patients or family * Arterial line * Burn patients : burn area between 20 and 50% (3rd degree) OR non burn patients Exclusion Criteria: * BMI \<30 * Sevoflurane anaphylaxia

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Conditions

The condition(s) this trial relates to.

burn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Icu patients with indication of sedation

Contacts and locations

Locations

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003, France