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Gel eases pain after gum graft surgery, study finds

NCT ID NCT07458685

Symptom relief Sponsor: University of Milan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a gel made from cross-linked hyaluronic acid to see if it helps gums heal after a gum graft. Twenty healthy adults took part. Half received the gel on the wound, while the other half did not. Participants rated their pain and healing over two weeks, with checkups up to 60 days. The goal was to see if the gel reduces discomfort and speeds up recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Sep 2022

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Good general health (ASA 1 or 2) * No local contraindications to implant surgery procedures (mucosal inflammation, active periodontal disease, erosive mucosal conditions, bone lesions, history of local radiation therapy and bruxism along with inadequate oral hygiene or lack of motivation for home care) * Presence of two adjacent implants either submerged or prosthetically loaded * Premolar and/or molar sectors of either the mandible or the maxilla * Presence of \< 2 mm of keratinized mucosa width at the buccal aspect of the said adjacent implants Exclusion Criteria: * Smokers (\> 10 cigarettes/day) * Subjects with known allergies to penicillin or collagen * Poor oral hygiene * Uncontrolled systemic pahologies * Active periodontal infection * No medical history of head and neck radiation therapy * No medical history of antiresorptive agents or steroids therapies * Pregnant or lactating women * Physical or mental disabilities affecting oral hygiene

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Palatal donor site wound healing Palatal wound

Contacts and locations

Locations

  • Implant Center for Edentulism and Jawbone Atrophies, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan

    Milan, Lombardy, 20122, Italy

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