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Can virtual reality reboot the brain after severe injury?

NCT ID NCT06474871

Symptom relief Sponsor: Anna Estraneo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests whether virtual reality (VR) exercises can improve cognitive functions like attention and problem-solving in people with severe acquired brain injury. Twenty-eight participants will be randomly assigned to either VR-based cognitive training or traditional paper-and-pencil exercises. The goal is to see if VR offers a better way to recover thinking skills in the months after injury.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Virtual reality rehabilitation system (Khymeia VRRS)
What this could lead to
If it works, this could offer a more engaging and effective way to help people recover cognitive function after severe brain injury.
What could go wrong
This is a small early-stage trial with only 28 participants, so results may not apply to everyone. VR may not be better than traditional therapy, and some people may find it uncomfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

Oct 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * LCF ≥4 at study entry; * Age 18-75 * Stable clinical diagnosis (i.e., stable LCF); * Time post-injury between 28 days and 6 months; * Ability to complete the pre-test A section of the Italian version of the Trail Making Test (TMT); * A pathological B-A score of the TMT according to normative data adjusted for age and education; * Signed informed consent by the patient or by the patient's primary caregiver. Exclusion Criteria: * Severe medical conditions that might hamper participation in the rehabilitation sessions, or influence diagnosis; * Previous neurodegenerative or acquired neurological diseases that affect cognitive domains (e.g., dementia)

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Conditions

The condition(s) this trial relates to.

brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acquired brain injury

Contacts and locations

Locations

  • ICS Maugeri

    Telese Terme, Benevento, 82037, Italy

  • ICS Maugeri

    Bari, Italy

  • IRCCS Santa Maria Nascente Fondazione Don Gnocchi ONLUS

    Milan, Milan, 20148, Italy

  • Ospedale Policlinico San Martino

    Genova, Italy

  • Polo Specialistico Riabilitativo Fondazione Don Carlo Gnocchi ONLUS

    Sant'Angelo dei Lombardi, Avellino, 83054, Italy

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