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Common drugs linked to Post-Surgery confusion in seniors

NCT ID NCT03390751

Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 161 older adults who had hip fracture or joint replacement surgery. Researchers checked if medications with a high 'atropine load' (a measure of anticholinergic effect) were linked to postoperative confusion. They used the Confusion Assessment Method daily and the Duran scale to rate drug atropine load. The goal is to help doctors choose safer drugs to prevent confusion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors choose safer medications during surgery to reduce confusion in elderly patients.
What could go wrong
This is a small observational study, not a treatment trial. It only looks for a link, so it cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

161 people

The number who actually took part.

Started

Dec 2017

Finished

Jan 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The recruitment of patients will be ensured from the consultation of anesthesia or the entry into hospitalization by the anesthesia team of the orthopedic surgery department of the Hospital.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Admitted to the orthopedic department for surgical management of a fracture of the upper end of the femur in emergency or for the installation of a hip or knee prosthesis * Patient able to understand and respond to the protocol * No opposition to the collection of data of the patient or his / her designee Exclusion Criteria: * Pre-existing confusion to surgery, detected by the CAM scale * Serious or moderate head trauma less than three months old * Removing / installing prosthesis.

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Conditions

The condition(s) this trial relates to.

Confusion hip fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging

Contacts and locations

Locations

  • Pierre-Paul-Riquet University Hospital

    Toulouse, 31000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.