Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can adding albumin improve burn resuscitation?

NCT ID NCT04356859

Disease control Sponsor: American Burn Association Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding albumin (a protein) to standard IV fluids helps adults with severe burns covering at least 25% of their body. 101 participants were randomly assigned to receive either standard fluids alone or standard fluids plus albumin during the first 24-48 hours after injury. The goal was to see if albumin reduces the total fluid needed and improves urine output and other outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Albumin (human)
What this could lead to
If adding albumin works, it could reduce the amount of fluid needed during burn resuscitation, potentially lowering complications like swelling and organ damage.
What could go wrong
This is a small, completed trial with 101 participants, so results may not apply to all burn patients. Albumin is expensive and may not improve survival or other key outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

101 people

The number who actually took part.

Started

Apr 2021

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Total burn size (second and third degree) is ≥ 25% of the TBSA * Burn center admission within 12 hours of injury. * There is a plan for formal fluid resuscitation. Exclusion Criteria: * Significant associated trauma * High voltage (≥ 1000 volts) electrical burns * Burn wound excision surgery within 48 hours from injury * Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury * Hypertonic saline (HTS) given at any time ≤ 48 hours from injury * Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury * High dose Vitamin C infusion given at any time ≤ 48 hours from injury * Administration of human albumin prior to randomization * Palliative comfort measures are instituted ≤ 48 hours from injury * Pregnancy * Pre-injury chronic renal insufficiency equal to or greater than stage 3 * Pre-injury chronic hepatic disease (Child-Pugh B or C) * Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Burn injury are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

burn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Burn injury

Contacts and locations

Locations

  • Arizona Burn Center Valleywise Health

    Phoenix, Arizona, 85008, United States

  • Ascension Via Christi St. Francis

    Wichita, Kansas, 67214, United States

  • Atrium Health Wake Forest Baptist Medical Center

    Winston-Salem, North Carolina, 27157, United States

  • Cooperman Barnabas Medical Center

    Livingston, New Jersey, 07039, United States

  • Erie County Medical Center

    Buffalo, New York, 14215, United States

  • Hennepin Healthcare

    Minneapolis, Minnesota, 55404, United States

  • Legacy Health

    Portland, Oregon, 97227, United States

  • Loyola Medicine

    Maywood, Illinois, 60153, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Metrohealth Medical Center

    Cleveland, Ohio, 44109, United States

  • Regional Burn Center at Harborview

    Seattle, Washington, 98014, United States

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N3M5, Canada

  • The University of Tennessee Health Science Center

    Memphis, Tennessee, 38163, United States

  • Torrance Memorial

    Torrance, California, 90505, United States

  • University of Alberta

    Edmonton, Alberta, AB T6G 1Z1, Canada

  • University of California Davis, Regional Burn Center

    Sacramento, California, 95817, United States

  • University of Cincinnati College of Medicine

    Cincinnati, Ohio, 45267, United States

  • University of Florida Health

    Gainesville, Florida, 32608, United States

  • University of Iowa Healthcare

    Iowa City, Iowa, 52242, United States

  • University of Kansas Health System

    Kansas City, Kansas, 66160, United States

  • University of Miami Health System

    Miami, Florida, 33136, United States

  • University of South Florida

    Tampa, Florida, 33606, United States

  • University of Utah Health

    Salt Lake City, Utah, 84132, United States

  • University of Wisconsin Health

    Madison, Wisconsin, 53792, United States

  • West Penn Hospital

    Pittsburgh, Pennsylvania, 15224, United States

  • Westchester Medical Center Health Network

    Valhalla, New York, 10595, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.