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What makes muscles weak in frail seniors after a hip break?

NCT ID NCT04764617

Knowledge-focused Sponsor: University of Nottingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 80 frail older adults who had hip surgery after a fall. Researchers took small muscle samples to measure fat, protein, and gene activity. The goal was to understand whether muscle amount or muscle function matters more for recovery. This is a knowledge-gathering study, not a treatment test.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify why some frail older patients recover poorly after hip surgery, pointing toward ways to improve muscle health and recovery.
What could go wrong
This is an observational study, not a treatment trial. It aims to gather knowledge, not test a therapy, so it won't directly change patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

80 people

The number who actually took part.

Started

Jan 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals \>65 years who have been admitted to Queens Medical Centre, Nottingham, UK for surgical repair of a hip fracture sustained following a low impact fall.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical Frailty Score (assessed as part of standard care) ≥ 4 * Fractured hip, sustained following a fall, that requires surgery * Good understanding of spoken and written English language * Able to give informed consent, or availability of a legally acceptable surrogate to provide consent Exclusion Criteria: * Those who fell and sustained their hip fracture greater than 12 hours prior to hospitalisation. * Those who have fallen and sustained a hip fracture whilst an in-patient in hospital * Those who sustained the hip fracture as a result of high impact trauma (e.g. road traffic accident) * Surgery carried out later than 96 hrs after fall * Chronic neurological, inflammatory or musculoskeletal disorders which result in muscle wasting, e.g. Multiple sclerosis, muscular dystrophy, rheumatoid arthritis * Any co-morbidity which precludes hip surgery * Those with a compromised swallowing reflex which would prevent the participant from taking fluids orally, will be excluded. * Those taking diabetes medication

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Conditions

The condition(s) this trial relates to.

Frailty hip fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Frailty syndrome

Contacts and locations

Locations

  • Queens Medical Centre; Department of Orthopaedics

    Nottingham, NG72UH, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.