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Can timed lung 'Recruitment' maneuvers protect Preemies' lungs?

NCT ID NCT04289324

Disease control Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this regular approach to standard care, measuring the oxygen saturation index over up to seven days of ventilation. It also tracks outcomes like days on a ventilator and the development of bronchopulmonary dysplasia, a chronic lung condition common in premature babies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Regular lung recruitment maneuvers (stepwise oxygenation-guided procedure) during high-frequency oscillatory ventilation
What this could lead to
If effective, this approach could improve oxygen levels and reduce lung injury in extremely preterm infants, potentially lowering the risk of chronic lung disease.
What could go wrong
This is a small, early-stage trial, so results may not be conclusive. The procedure itself could cause temporary changes in blood pressure or oxygen levels, and benefits may not persist.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Feb 2020

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 8 weeks

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Preterm infants * born below 28 weeks of gestational age * not older than 29 weeks of postmenstrual age * receive HFOV Exclusion Criteria: * known congenital anomalies of the heart, of the lung, and/or of the central nervous system * known chromosomal abnormalities * participation in other intervention trials

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Conditions

The condition(s) this trial relates to.

acute lung injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extreme prematurity High frequency oscillation ventilation Lung injury, acute

Contacts and locations

Locations

  • Medical University of Vienna

    Vienna, State of Vienna, 1090, Austria

More trials for these conditions

Other studies related to the condition(s) this trial covers.