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Scientists hunt for brain injury fingerprints in blood and spit

NCT ID NCT01171131

Knowledge-focused Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects of head trauma and identify new targets for treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could point toward new targets for treating long-term effects of traumatic brain injury.
What could go wrong
This is a small pilot study (96 people) that only looks for markers, not a treatment. The findings may not lead to any new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

96 people

The number who actually took part.

Started

Apr 2010

Finished

Mar 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

TIRR Clinics

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Chronic TBI patients: Inclusion Criteria Have a history of head trauma manifesting in one or more of the following: * Loss of consciousness * Post-traumatic amnesia * Focal neurologic deficits, seizure * Persistent symptoms of increased arousal (e.g. difficulty falling or staying asleep, anger and hypervigilance) * Impairment in social, occupational, or other important areas of functioning (e.g. problems with work and relationships.) Exclusion Criteria Inability to obtain informed consent and if they are non-communicative (i.e. in a vegetative state). Healthy volunteers: Inclusion Criteria * No significant medical history * Take no medications (other than birth control pills) * Fever free * No history of head trauma or recent injury/infection * No history of neurological or psychiatric disorders or alcohol or drug dependency. Exclusion Criteria * Inability to provide informed consent * age/gender match not available in TBI cohort

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic brain injury dementia pugilistica traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic brain injury

Contacts and locations

Locations

  • TIRR

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.