Painless spinal zaps may restore hand movement after paralysis
NCT ID NCT03184792
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. The goal was to see if the stimulation could help rewire the spinal cord and improve motor control. The treatment was painless and did not require surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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15 people
The number who actually took part.
- Started
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Dec 2017
- Finished
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Dec 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Cervical (C7 or higher) spinal cord injury at least 1-year duration * Incomplete spinal cord injury (American Spinal Injury Association Impairment Scale (AIS) C or D) * Between 21 and 70 years of age * Difficulty with hand functions in activities of daily living (e.g. dressing, grooming, feeding) * Stable medical condition without cardiopulmonary disease or frequent autonomic dysreflexia that would contraindicate participation in upper extremity rehabilitation or testing activities * Capable of performing simple cued motor tasks * Ability to attend 2 to 5 sessions of weekly physical therapy sessions and testing activities * Adequate social support to be able to participate in weekly training and assessment sessions for the duration of 6 months within the study period. * Ability to read and speak English Exclusion Criteria: * Autoimmune etiology of spinal cord dysfunction/injury * History of additional neurologic disease, such as stroke, multiple sclerosis, traumatic brain injury, etc. * Peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.) * Rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.) * Significant medical disease; including uncontrolled systemic hypertension with values above 170/100 mmHg; cardiac or pulmonary disease; uncorrected coagulation abnormalities or need for therapeutic anticoagulation. * Active cancer * Cardiovascular or musculoskeletal disease or injury that would prevent full participation in physical therapy intervention * Unhealed fracture, contracture, pressure sore, or urinary tract infection or other illnesses that might interfere with upper extremity rehabilitation or testing activities * Any condition that would render the patient unable to safely cooperate with the study tests as judged by the screening physician * Pregnancy * Tendon or nerve transfer surgery in the upper limbs * Botulinum toxin injections in the prior 6 months * Dependent on ventilation support * Implanted stimulator (e.g. vagus nerve stimulator, pacemaker, cochlear implant, etc). * Has depression or anxiety based on Patient Health Questionnaire and General Anxiety Disorder-7 item Questionnaire * Diagnosed with syringomyelia * Alcohol and/or drug abuse. * Cognitive impairment based on Short Portable Mental Status Questionnaire * Unable to read and/or comprehend the consent form. * Unable to understand the instructions given as part of the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Washington
Seattle, Washington, 981095, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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