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Painless spinal zaps may restore hand movement after paralysis

NCT ID NCT03184792

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. The goal was to see if the stimulation could help rewire the spinal cord and improve motor control. The treatment was painless and did not require surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

15 people

The number who actually took part.

Started

Dec 2017

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cervical (C7 or higher) spinal cord injury at least 1-year duration * Incomplete spinal cord injury (American Spinal Injury Association Impairment Scale (AIS) C or D) * Between 21 and 70 years of age * Difficulty with hand functions in activities of daily living (e.g. dressing, grooming, feeding) * Stable medical condition without cardiopulmonary disease or frequent autonomic dysreflexia that would contraindicate participation in upper extremity rehabilitation or testing activities * Capable of performing simple cued motor tasks * Ability to attend 2 to 5 sessions of weekly physical therapy sessions and testing activities * Adequate social support to be able to participate in weekly training and assessment sessions for the duration of 6 months within the study period. * Ability to read and speak English Exclusion Criteria: * Autoimmune etiology of spinal cord dysfunction/injury * History of additional neurologic disease, such as stroke, multiple sclerosis, traumatic brain injury, etc. * Peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.) * Rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.) * Significant medical disease; including uncontrolled systemic hypertension with values above 170/100 mmHg; cardiac or pulmonary disease; uncorrected coagulation abnormalities or need for therapeutic anticoagulation. * Active cancer * Cardiovascular or musculoskeletal disease or injury that would prevent full participation in physical therapy intervention * Unhealed fracture, contracture, pressure sore, or urinary tract infection or other illnesses that might interfere with upper extremity rehabilitation or testing activities * Any condition that would render the patient unable to safely cooperate with the study tests as judged by the screening physician * Pregnancy * Tendon or nerve transfer surgery in the upper limbs * Botulinum toxin injections in the prior 6 months * Dependent on ventilation support * Implanted stimulator (e.g. vagus nerve stimulator, pacemaker, cochlear implant, etc). * Has depression or anxiety based on Patient Health Questionnaire and General Anxiety Disorder-7 item Questionnaire * Diagnosed with syringomyelia * Alcohol and/or drug abuse. * Cognitive impairment based on Short Portable Mental Status Questionnaire * Unable to read and/or comprehend the consent form. * Unable to understand the instructions given as part of the study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Washington

    Seattle, Washington, 981095, United States

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