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Could short bursts of low oxygen help heal the brain?

NCT ID NCT04890639

Knowledge-focused Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether brief sessions of breathing low-oxygen air are safe for people who have had a traumatic brain injury (TBI). Twelve adults with mild to moderate TBI received up to four sessions of acute intermittent hypoxia, where oxygen levels were briefly lowered. Researchers monitored vital signs and symptoms to check for side effects and also looked for any improvements in memory, thinking, and motor control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acute Intermittent Hypoxia (brief low-oxygen breathing sessions)
What this could lead to
If safe and effective, this approach could point toward a new way to boost brain recovery after traumatic brain injury.
What could go wrong
This is a very small, early safety study with only 12 participants, so results may not apply widely. The treatment involves low oxygen, which could cause side effects like dizziness or shortness of breath.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Mar 2022

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-65 years * A first time, mild to moderate traumatic brain injury (TBI) confirmed by medical records * When available, a Glasgow Coma Scale score between 9-15 * Able to use a keyboard * Able to understand and communicate in English * Able to consent independently * Able to leave a research visit with a companion/group transportation * Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study * Not involved in any other research intervention study testing neurobehavioral functioning Exclusion Criteria: * Other neurological diagnoses or a diagnosis of severe psychiatric disorder (e.g., psychosis) or a reported childhood learning disability * Severe aphasia, preventing a participant from understanding the protocol and consent form * Pre-existing hypoxic pulmonary disease * Severe hypertension (\>160/100) * Medically documented history of obstructive lung diseases \[e.g., Chronic obstructive pulmonary disease (COPD) or significant asthma\] * Ischemic cardiac disease * Ineligible to undergo MRI or TMS

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic Hypoxia traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain injuries, traumatic

Contacts and locations

Locations

  • Shirley Ryan AbilityLab

    Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.