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Which anesthetic protects the injured brain better?

NCT ID NCT07244822

Symptom relief Sponsor: Universitas Jenderal Soedirman Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested two different anesthetic drugs—dexmedetomidine and sufentanil—in 28 people having surgery for traumatic brain injury. The goal was to see which one keeps the brain's oxygen levels more stable during and after the operation. Researchers measured oxygen saturation in the brain using a special light-based monitor. The results could help doctors choose the best anesthetic for these critical surgeries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine and Sufentanil
What this could lead to
If dexmedetomidine proves better at maintaining brain oxygen levels, it could become a preferred anesthetic for traumatic brain injury surgery.
What could go wrong
This is a very small, completed trial (28 people) that only measures a short-term oxygen level, not long-term recovery or survival. Results may not apply to all TBI patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

Jun 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-65 years diagnosed with traumatic brain injury (TBI) requiring surgical intervention under general anesthesia. * Classified as ASA Physical Status I-III. * Undergoing elective or emergency craniotomy at RSUD Prof. Dr. Margono Soekarjo Purwokerto. * Provide informed consent (patient or legal representative). Exclusion Criteria: * Patients with severe cardiovascular instability (e.g., shock, uncontrolled arrhythmia). * History of allergy or hypersensitivity to dexmedetomidine or sufentanil. * Severe hepatic or renal impairment. * Pregnant or lactating women. * Glasgow Coma Scale ≤ 8 before induction. * Refusal of participation or incomplete consent.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral oxygen saturation Nir spectroscopy Traumatic brain injury

Contacts and locations

Locations

  • RSUD Prof. Margono Soekarjo

    Purwokerto, Central Java, 53122, Indonesia

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