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Blood test may spare Head-Injury patients on blood thinners from unnecessary CT scans

NCT ID NCT03780062

Diagnosis Sponsor: Poitiers University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether measuring S100B protein levels in the blood can safely rule out serious brain injuries in adults with minor head trauma who take antiplatelet drugs (blood thinners). 720 participants had a blood test upon arriving at the emergency room, followed by a CT scan 4-8 hours later. The goal was to see if a low S100B level could reliably predict no need for surgery or hospitalisation, potentially avoiding CT scans and radiation exposure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
S100B protein blood test
What this could lead to
If successful, this blood test could help doctors quickly rule out dangerous brain injuries in patients on blood thinners after a minor head bump, reducing the need for CT scans.
What could go wrong
This is a completed Phase 3 trial, but the test may not be accurate enough in all patients, and false negatives could miss serious injuries. Results need validation in broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

720 people

The number who actually took part.

Started

Jan 2019

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 Years old * Minor traumatic brain injury measured by a Glasgow score between 13 and 15 * Antiplatelet agent therapy * Free subject without tutorship or curatorship Exclusion Criteria: * Age \< 18 years old * Glasgow score \<13 * Traumatic brain injury older than 6 hours * Patient without any social security system * Patient with renforced protection (tutorship, curatorship, …)

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Conditions

The condition(s) this trial relates to.

traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Minor traumatic brain injury Treatment by antiplatelet

Contacts and locations

Locations

  • CHU of MONTPELLIER

    Montpellier, 34090, France

  • CHU of NICE

    Nice, 06003, France

  • CHU of POITIERS

    Poitiers, 86021, France

  • La Pité Salpêtrière

    Paris, 75013, France