Warm oxygen through the nose may help brain injury patients breathe easier after ventilator
NCT ID NCT07664085
First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 2 times
Summary
This study looks at two ways to give oxygen to people with acute brain injury after their breathing tube is removed. One method uses a high-flow nasal cannula, which delivers warm, moist oxygen through the nose. The other is conventional oxygen therapy, like a face mask or nasal prongs. Researchers want to see which approach better prevents breathing failure, such as needing a tube reinserted or extra breathing support, within five days after extubation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- high-flow nasal cannula therapy
- What this could lead to
- If high-flow nasal cannula proves better, it could become the standard oxygen method after extubation for brain injury patients, reducing the need for re-intubation.
- What could go wrong
- This is an observational study, not a randomized trial, so results may be influenced by patient differences. The findings need confirmation in larger, controlled studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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285 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jan 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult post-neurosurgical patients with acute brain injury who were admitted to the Surgical Intensive Care Unit of Bach Mai Hospital, required invasive mechanical ventilation for at least 24 hours, and underwent planned extubation after meeting clinical readiness criteria. Patients received either high-flow nasal cannula or conventional oxygen therapy after extubation according to routine clinical practice and the attending ICU physician's decision.
- Ages
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16 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 16 years or older. * Admission to the Surgical Intensive Care Unit after neurosurgery for acute brain injury, including traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, ischemic stroke, or other acute neurosurgical brain conditions. * Requirement for invasive mechanical ventilation for at least 24 hours. * Undergoing planned extubation after clinical assessment by the treating ICU team. * Successful completion of a spontaneous breathing trial lasting 30 to 120 minutes. * Adequate airway protection, defined as an Airway Care Score less than 8 points. * Neurological readiness for extubation, as assessed by Glasgow Coma Scale score and bedside neurological examination. * Adequate oxygenation before extubation, including PaO2/FiO2 greater than 200 mmHg and PEEP less than 7 cmH2O. Exclusion Criteria: * Pre-existing tracheostomy. * Known upper airway obstruction, including airway stenosis or airway tumor. * Suspected cerebrospinal fluid leak or complex skull base fracture. * Unplanned self-extubation. * Requirement for immediate prophylactic reintubation before initiation of post-extubation oxygen therapy. * Requirement for non-invasive ventilation before initiation of the study exposure. * Missing key clinical data required for outcome assessment or propensity score matching.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bach Mai Hospital, Hanoi, Viet Nam.
Hanoi, Hanoi, 00000, Vietnam
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Other studies related to the condition(s) this trial covers.
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