Injury

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take par…

Researchers at a Korean hospital are following 210 adults who receive a cementless total hip replacement using the collarless Actis femoral stem. The study focuses on Asian patients, who tend to be younger at surgery and more often need the operation because of lost blood supply …

This trial compares two common diuretics—furosemide and mannitol—given during kidney transplant surgery to see which better prevents delayed graft function, a condition where the new kidney does not work right away and requires dialysis. The study enrolls adults receiving a decea…

This study tests two approaches for children under 18 with life-threatening bleeding from trauma. One compares whole blood to standard blood components; the other tests tranexamic acid against placebo. The goal is to see which reduces death within 24 hours. Up to 1,000 children w…

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that often requires a breathing machine. This trial compares two ways of using that machine: airway pressure release ventilation (APRV), which holds the lungs open longer with brief releases, and convent…

This early-stage trial tests a new antibody called HT31-1 in 24 healthy volunteers to see if it is safe and how the body processes it. The antibody targets a protein linked to inflammation in acute respiratory distress syndrome (ARDS), a severe lung condition often caused by infe…

This study tests whether personalized weight-bearing instructions using smart crutch tips can help heal tibia fractures faster. Thirty adults who had surgery for a broken shinbone will use sensor-equipped crutch tips that give real-time feedback on how much weight they put on the…

This study tests a technique called remote ischemic preconditioning (RIPC) during emergency surgery for a life-threatening aortic tear. RIPC involves briefly inflating a blood pressure cuff on the arm and thigh to temporarily restrict blood flow, which may help protect the heart,…

Researchers are collecting data on people who receive Equinoxe proximal humerus fracture plates, a type of hardware used to repair broken upper arm bones near the shoulder. The study follows participants for up to 10 years after surgery, tracking shoulder motion, pain, and daily …

This study tests whether giving tranexamic acid early after a traumatic brain injury can reduce harmful inflammation. Researchers will enroll 60 adults with mild or moderate head injuries. The goal is to see if this drug can help control the body's inflammatory response and impro…

Researchers are collecting data on ViviGen, a donated cellular bone matrix used as a graft during orthopaedic surgery. The study follows patients with acute fractures, delayed healing, non-union fractures, or spinal fusion to see how often they need a second operation within a ye…

This study tests whether a 5-day course of the steroid methylprednisolone can improve long-term recovery in adults with moderate to severe traumatic brain injury. 520 participants will receive either the drug or a placebo, added to standard care. Researchers will measure neurolog…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This Phase 3 trial tests whether antibiotic cement beads or negative pressure wound therapy (a wound vac) works better for severe open tibia fractures. 312 adults with these injuries will be randomly assigned to one of the two treatments. Researchers will compare death, amputatio…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study compares oral (pill) antibiotics to intravenous (IV) antibiotics for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to receive either oral or IV antibiotics for up to 6 weeks after surgery. Th…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This study compared three devices used to wire broken jaws together: Erich arch bars, IMF screws, and hybrid arch bars. Twenty-four adults with mandibular fractures were randomly assigned to one of the three devices. The goal was to see which device provides the best stability an…

This study tests a liquid agent called Onyx™ that is injected into arteries to block active bleeding outside the heart and brain. It includes 119 adults with severe bleeding from trauma, ulcers, or other causes. The goal is to see if it safely stops bleeding without needing furth…

Researchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…

This study tests whether a special tilt-table with robotic leg movers (called Erigo) helps people with severe brain injuries recover better than traditional tilting. The table slowly brings patients upright while moving their legs, which may improve blood flow, muscle tone, and a…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This trial tests whether citicoline, a neuroprotective agent, can prevent or slow cognitive decline in older adults who develop delirium while hospitalized for a hip fracture. Delirium is a common complication that can lead to lasting memory and thinking problems. Participants wi…

This study compares two common surgeries for a certain type of hip fracture in adults aged 60 and older: hip replacement (arthroplasty) versus internal fixation (using screws or pins). The goal is to see which approach helps people survive, walk independently, and spend more time…

This trial tests whether marking a safety zone on the face before surgery can help protect the facial nerve when fixing a broken jaw through a cheek incision. The safety zone is a triangle drawn between the ear, the outer corner of the eye, and the lower jaw edge. Researchers wil…

This study compares two ways to treat a broken elbow (olecranon fracture) in people over 65 who don't use their arms heavily. Half will get surgery with a metal plate and screws, and the other half will get a cast or splint. Researchers will measure elbow function, pain, and qual…

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial tests whether injecting a person's own bone marrow into a hip fracture site helps the bone heal faster and more completely. Adults aged 18 to 55 with a specific type of hip fracture will receive either standard screw fixation alone or screw fixation plus a bone marrow …

This trial tests whether a device that sends mild electrical pulses to the spinal cord can help people with a cervical spinal cord injury breathe more independently. Twenty adults with a C1-C5 injury who need a ventilator will have electrodes implanted near the injury site and re…

This study is testing a device called the TrueLok Elevate that uses a technique called transverse bone transport to help heal chronic lower limb ulcers. The device is attached to the leg and slowly moves a piece of bone to stimulate blood flow and tissue healing. Researchers will…

This study will test a new medical device kit (Novalung ultimate kit with Xenios 2.0) in 20 adult patients with severe heart-lung failure who need ECMO life support. The goal is to see if the device safely and effectively maintains blood oxygen levels during hospital use and grou…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests whether a vacuum dressing (negative pressure wound therapy) reduces infection compared to standard bandages after skin graft surgery for leg tumors. About 242 adults will be randomly assigned to one of the two dressings. The main goal is to see if the vacuum dres…

This trial tests whether adding bone cement to the standard metal nail used in hip fracture surgery helps the repair hold together better. People aged 75 and older with a certain type of hip fracture will be randomly assigned to receive either the standard surgery or the surgery …

This study tests whether giving plasma (a part of blood) as soon as possible to adults with severe burns over at least 20% of their body can lower the chance of death or organ failure. About 750 patients will be randomly assigned to receive either early plasma or standard fluids.…

This trial compares two surgical techniques for fixing a type of elbow fracture where the bone ends are separated but the joint remains stable. One method uses pins and wire (tension band wiring), while the other uses wire alone (cerclage fixation). Researchers will randomly assi…

This trial compares two common IV fluids—normal saline and balanced crystalloid—to see which one leads to better recovery in people with moderate to severe traumatic brain injury (TBI). Participants receive one of the fluids during their hospital stay, and their neurological outc…

This trial is testing an implantable wireless brain-computer interface (BCI) in people with tetraplegia caused by cervical spinal cord injury. The device is designed to read brain signals and translate them into commands to control external devices, such as a computer cursor or a…

This study will follow 120 adults aged 60 and older who have a pelvic fracture and are scheduled to receive the iFuse TORQ TNT implant, a screw-like device that stabilizes the pelvis. Researchers will check if the device stays in place, doesn't break, and doesn't require addition…

This phase II trial tests whether adapting radiation plans mid-treatment using MRI scans can reduce swallowing difficulties in patients with advanced oropharynx (throat) cancer. Participants receive standard chemoradiation, but half are randomly assigned to have their radiation p…

This trial tests whether a specialized physical therapy technique called blood flow restriction training (BFRT) can improve recovery in people who have experienced a patellar dislocation (kneecap slipping out of place). Participants will undergo 8 weeks of either BFRT or a sham v…

This study compares two surgical methods for treating severe tibial plateau fractures (Schatzker types V and VI) — a locking plate versus a hybrid Ilizarov external fixator. Adults aged 25 to 50 with such fractures will be randomly assigned to one of the two procedures. The main …

This trial tests whether a protein-rich diet combined with supervised resistance exercise can improve recovery in older adults who have had a hip fracture. Participants will follow this program for three months, and researchers will measure changes in physical function, muscle ma…

This trial tests whether adding legal support to standard violence recovery care can lower stress and reduce repeat firearm injuries. People treated for violent injuries at a trauma center receive either standard support or additional help with legal issues like benefits and hous…

This trial compares two surgical techniques for repairing a broken shin bone (tibial shaft fracture) using a metal rod inside the bone. The two approaches—medial parapatellar and transpatellar—differ in how the surgeon reaches the bone. About 56 adults with acute tibial fractures…

This trial tests whether a 14-week, individually tailored home-based rehabilitation program called 'Stronger at Home' can improve functional recovery in older adults who have had a hip fracture. Participants will receive visits from a physical therapist, a self-directed toolkit w…

This trial asks whether giving severely injured patients whole blood (Low-Titer Group O) is better than giving them separate blood components (red cells, plasma, platelets, and cryoprecipitate) during emergency transfusions. It enrolls about 1,100 adults with major traumatic blee…

This trial tests whether Angiotensin (1-7), a synthetic version of a natural protein fragment, is safe and effective for people with moderate to severe traumatic brain injury (TBI). Participants receive a daily injection for 21 days, along with blood tests, MRI scans, and cogniti…

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-i…

This trial tests whether applying tranexamic acid (TXA) directly to the surgical site during hip fracture surgery can reduce the need for blood transfusions in elderly patients. Participants receive TXA either as an injection through a drain tube or as a topical soak, compared to…

This study is tracking 200 adults who receive the Ennovate Cervical Spinal System, a metal implant used to stabilize the neck and upper back after fractures, disc disease, or tumors. Researchers will measure changes in pain and quality of life over time. The goal is to confirm th…

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This trial tests whether locking a metal nail only on one side of a broken upper arm bone (unipolar interlocking) works as well as locking it on both sides (bipolar interlocking). The simpler technique may lower the risk of nerve injury, infection, and radiation exposure. About 3…

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the …

This study tests whether clemastine, an allergy medicine, is safe for premature babies with white matter injury—a common brain injury in infants born early. Researchers will give the drug by mouth to 24 babies born at or before 32 weeks and now between 35 and 41 weeks old. The go…

This study tests a robot-assisted, gamified rehabilitation program for children aged 7-16 with acquired brain injury. The program combines 15 supervised hospital sessions with 15 home-based sessions on a tablet, guided by an interactive avatar. Researchers will measure improvemen…

This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The c…

This trial compares two ways to manage the wound after surgical removal of a chronic pilonidal sinus. Half of the 200 participants will receive a negative pressure wound therapy (NPWT) dressing that applies gentle suction to the wound, while the other half will receive standard o…

This trial tests whether an implantable brain-computer interface (BCI) can help people with tetraplegia from spinal cord injury regain hand function. Participants receive a surgically implanted BCI that reads brain signals and controls pneumatic gloves to assist with grasping and…

This trial investigates whether a single-use negative pressure wound therapy (NPWT) device, which applies gentle suction to the closed incision, can reduce surgical site infections, wound complications, and improve scar appearance compared to standard dressings after major lower …

This study investigates whether combining electrical stimulation of the abdominal and back muscles with specific breathing exercises can improve the strength of an unaided cough in people with acute spinal cord injury. Participants will use a device called the Xcite system to del…

This trial investigates whether two special wound dressings—one made from donated amniotic membrane and another from a synthetic material—can help heal diabetic foot ulcers and venous leg ulcers that have not responded to standard care. Adults aged 18 and older with these hard-to…

This study tests a new approach for liver transplantation: after keeping the donor liver warm on a machine, doctors skip the usual cold flush before implanting it. Instead, they use a room-temperature albumin rinse. The goal is to see if avoiding sudden temperature changes reduce…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This trial tests whether robot-assisted therapy using the ArmeoSpring exoskeleton improves arm and hand function more than conventional occupational therapy in people with cervical spinal cord injury. Each participant receives both therapies in random order, allowing direct compa…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spinal cord is safe and practical for people with spinal cord injury. It includes 30 adults with either non-traumatic spinal cord injury (from cervical myelopathy) or traumatic injur…

This study investigates whether a home-based, telehealth-supported program combining blood flow restricted exercise and transspinal stimulation can improve hand and arm function in people with chronic, incomplete tetraplegia. Participants will perform task-specific activities whi…

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compa…

This trial looks at two approaches for treating displaced wrist fractures in children aged 4 to 10. One group gets the standard sedated reduction (where the bone is realigned under sedation) followed by a cast. The other group gets only a cast without any realignment. The study m…

This study compares two radiotherapy schedules for men whose prostate cancer has returned after surgery. The standard treatment takes 5 weeks, while the shorter one takes 4 weeks. Researchers want to see if the shorter schedule causes no more side effects and controls the cancer …

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This pilot study tests a new way to make a custom pressure orthosis for burn scars using 3D scanning and printing. About 25 adults with healing hypertrophic burn scars will get the device. The main goal is to see if the manufacturing process works and the orthosis fits safely.

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This early study tests a new implantable sensor array, called Phantom X, that picks up muscle signals to control a bionic arm. Ten adults with below-elbow amputations will receive the implant and be followed for up to 21 weeks. The goal is to see if the device is safe and allows …

This trial investigates the safest time to restart direct oral anticoagulants (DOACs) after a traumatic brain bleed. Many older adults who fall and hit their head are on blood thinners for conditions like atrial fibrillation, and stopping them raises the risk of stroke or clots. …

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if …

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This small pilot study tests whether cutting a fibrous strand at the end of the spinal cord (filum terminale) can relieve symptoms of occult tethered cord syndrome better than medical management alone. Twenty people aged 2 to 80 who have not improved with standard care will be ra…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This pilot study tests whether giving trauma patients whole blood instead of separate red blood cells and plasma before reaching the hospital is feasible and improves outcomes. About 60 adults with severe traumatic bleeding will be randomly assigned to receive either two units of…

This study is testing whether epidural stimulation—a device placed near the spinal cord—can improve walking, standing, and bladder function in people who have had a spinal cord injury within the past year. Sixteen participants will receive stimulation combined with stand training…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study compares two common seizure medications, levetiracetam and lacosamide, to see which works better at preventing early seizures after a traumatic brain injury. Researchers will also track side effects like agitation and sedation. The trial plans to enroll 600 adults with…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This study tests whether adding a piece of donated hip bone (femoral allograft) to standard plate surgery helps people aged 40-70 recover better from severe shoulder fractures. Half the participants will get the graft plus a plate, the other half just the plate. Researchers will …

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests a special wound dressing made from sheep stomach lining, used with a vacuum device, to see if it helps cover exposed bone or tendon faster than the vacuum device alone. About 30 adults with soft tissue wounds on an arm or leg will take part. The goal is to see if…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study tests whether a spinal cord stimulator — a device that sends mild electrical pulses to the spinal cord — can help people with long-term bladder and bowel problems after a spinal cord injury. Ten adults with injuries older than 6 months will have the device implanted an…

This study tests a special silicone jacket that wraps around a donor kidney during transplant surgery to keep it warm. The goal is to see if the jacket is safe to use in different types of kidney transplants. Twenty adult recipients will be enrolled, and the study will track any …

This study tests whether starting leg cycling within the first week after a traumatic spinal cord injury can reduce complications like pneumonia and pressure sores, and improve nerve recovery. About 102 adults with recent spinal cord injuries will take part. The goal is to see if…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This Phase 3 trial tests whether a single injection of tranexamic acid, given within 3 hours of a mild head injury, can reduce brain bleeding, disability, and death in adults aged 50 and older. The study aims to enroll 5,000 participants and compares the drug to a placebo. If suc…

This study tests whether a special vacuum dressing placed on the surgical wound can reduce complications like infection and re-operation in people with soft-tissue sarcoma of the leg who had radiation before surgery. About 291 adults will be randomly assigned to get either the va…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study tests whether a daily injection of BPC 157, a synthetic peptide, can help people with a moderate hamstring tear heal faster. 120 adults aged 18-45 with a recent MRI-confirmed grade II strain will receive either BPC 157 or a placebo for 14 days, plus standard rehab. The…

This study tests a new device called MIRA, which is implanted under the skin to pick up electrical signals from muscles in the arm. These signals are then used to control a robotic prosthetic hand. The trial involves 5 adults with a below-elbow amputation who will use the device …

This early-stage trial tests a new device designed to deliver OPC1 cells directly into the spinal cord of people with traumatic spinal cord injuries. The study will enroll 10 participants with either recent or chronic injuries. The main goal is to see if the device and injection …

This study tests two non-invasive techniques to improve breathing in people with chronic spinal cord injury. Participants will receive spinal cord stimulation and breathe special air mixtures to strengthen breathing muscles. The study involves 20 adults with incomplete spinal cor…

This study compares two types of surgery for unstable ankle fractures in frail adults aged 60 and older. One group gets ankle fusion (joining the bones together), and the other gets open reduction and internal fixation (using plates and screws to hold the bones in place). A secon…

This study is for adults over 21 with chronic spinal cord injury (more than a year) who have lost motor function. Researchers will implant a spinal cord stimulator and combine it with advanced robotic rehabilitation to see if it can improve movement, like walking. The main goal i…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…

This study tests whether Maraviroc, a drug already approved for HIV, can prevent a serious lung injury called primary graft dysfunction (PGD) after a lung transplant. PGD is a major cause of death in the first year after transplant, and there are no approved treatments for it. Ab…

This study looks at whether antibiotics are needed after surgery for a broken jaw. Many doctors prescribe them to prevent infection, but overuse can lead to antibiotic resistance. The trial will compare three approaches: no antibiotics after surgery, a short course, or a longer c…

This study tests whether a special egg yolk powder called Salovum can help people with severe traumatic brain injury. Half of the 20 participants get Salovum, the other half get a placebo. Researchers will measure brain pressure, oxygen levels, and inflammation to see if the trea…

This study looks at a new way to fix a common elbow fracture in children using anchors with sutures instead of screws or pins. The goal is to reduce problems like hardware irritation and the need for a second surgery to remove implants. Nine children under 15 with displaced fract…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

Researchers at a Baghdad hospital are comparing four trauma severity scoring systems, ISS, NISS, RTS, and TRISS, to see which one best predicts whether an injured patient will die in the hospital. The study follows 150 trauma patients admitted to the emergency department, calcula…

This trial is testing whether advanced PET-CT scans can spot early signs of heart damage caused by standard radiation therapy for locally advanced non-small cell lung cancer. Ten adults with stage III lung cancer will receive a special PET-CT scan before and three months after th…

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study tests a digital tool called Neuralix, designed to assess memory and thinking skills in adults who have had moderate to severe head trauma. Researchers will check how well the battery detects cognitive issues in patients and compare results with healthy volunteers to se…

This study investigates whether a bedside ultrasound of the head, called cranial point-of-care ultrasound (cPOCUS), can accurately detect brain injuries in children who would normally receive a CT scan or MRI. The goal is to see if this safe, fast, and radiation-free tool could h…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study is testing a new device called Traq™ that measures how well both eyes work together, including fixation and eye movement speed. The goal is to see if these measurements can help tell apart people who have had a recent mild traumatic brain injury (concussion) from those…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study is testing whether a bedside ultrasound can accurately detect skull fractures in children aged 6 and under who have minor head injuries with a scalp bruise. Researchers will compare ultrasound results to a standard CT scan in 150 children. If ultrasound proves reliable…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study tests whether a very powerful 7 Tesla MRI can detect tiny brain injuries in people with post-concussion syndrome after a mild head trauma. Researchers will scan 100 patients one week after their injury and compare the results to standard tests. The goal is to see if th…

This study is testing whether a set of computerized attention tests can identify attention problems caused by a concussion in young rugby players aged 11 to 25. Thirty athletes who recently had a concussion will take the tests, and their results will be compared to those of 60 at…

This study looks at whether a special ultrasound (CEUS) can find hidden bleeding pockets (pseudoaneurysms) in the liver, spleen, or kidneys after an injury, just as well as the standard CT scan. About 385 adults with abdominal trauma will be followed over time with both tests. If…

This study is testing whether a simple saliva test can help detect concussions in professional rugby players. Researchers will measure specific proteins and genetic material in saliva before and after matches, and compare them with impact data from special mouthguards. The goal i…

This study looks at whether ultrasound can reliably detect broken bones in the elbow of children aged 5 to 15 after an accident. About 543 kids will get both an ultrasound and standard X-rays, and researchers will compare the results. If ultrasound proves accurate, it could offer…

This study is testing a new device called TES HT100 that uses low-power electromagnetic waves to screen for brain injuries in adults coming to the emergency room with mild head trauma or certain neurological symptoms. The device is non-invasive, takes about 5 minutes, and gives a…

This study tests whether a special dye called ICG, used with a new imaging device, can help surgeons see how healthy a patient's bone is during surgery. Ten adults with open fractures or bone infections will receive the dye and be imaged. The goal is to see if this technique can …

This study is working on a new way to diagnose concussions in athletes using a simple saliva test. Researchers will measure specific molecules in the saliva of 80 male athletes (professional, amateur, and occasional) before, during, and after exercise. The goal is to find reliabl…

This study tests a program called COACH that trains youth football coaches on safer practice planning to reduce head impacts and concussions. Researchers will track head impacts and cognitive changes in 880 players over a season. The goal is to see if the program is both practica…

Open tibia fractures break the skin and expose bone, which lets bacteria in and leads to infections that can cause disability. Researchers in Tanzania are testing whether applying the antibiotic gentamicin directly to the wound during surgery prevents infection better than saline…

People who suffer spinal cord injuries face a high risk of dangerous blood clots, and doctors usually prescribe enoxaparin, a daily injection, to prevent them. This trial compares enoxaparin with apixaban, an oral blood thinner, in 60 adults recovering from spinal cord injury at …

This trial tests whether giving an inhaled medication called dornase alfa to severely injured patients on breathing machines can lower their risk of developing acute respiratory distress syndrome (ARDS), a serious lung condition. The drug is thought to break down DNA fragments re…

This trial tests whether altering sex hormone levels can make muscles, tendons, and bones more resilient to the physical and mental stress of military-style training. Healthy adults aged 18-40 will undergo a 4-week training program, with some receiving goserelin to suppress hormo…

This study tests whether applying paraffin oil to the skin before using a tourniquet (a tight band that stops blood flow) during arm surgery can prevent skin injuries like redness, blisters, or burns. About 90 adults having elective upper arm surgery will be randomly assigned to …

This study tests a community-driven program to reduce gun violence in seven high-risk New Haven neighborhoods. It provides housing financial assistance and financial education to recently incarcerated people and their families, and trains local residents in trauma-informed counse…

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study tests a device called the Verus frame, which supports the leg during surgery to fix a broken shinbone. The goal is to see if it helps surgeons align the bone more accurately. Twenty-five adults with tibial fractures will be enrolled, and their results will be compared …

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study compares two approaches for breast cancer patients who still have cancer in their sentinel lymph node after chemotherapy: removing the underarm lymph nodes (surgery) or treating them with radiation. The goal is to see if radiation can reduce the risk of arm swelling (l…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce urinary incontinence in people with recent spinal cord injury. Twenty adults with at least two leaks per day will take a purified CBD drug (Epidiolex) twice daily for 90 days. The main goal is to see…

Researchers are testing whether epidural electrical stimulation can improve bladder function in people with spinal cord injuries. The trial enrolls adults with injuries above T11 who have trouble urinating and rely on catheters. Participants receive an implanted spinal cord stimu…

This early-stage study is checking if insulin nasal spray is safe for people with spinal cord injury. Up to 12 adults who had an injury at least 4 months ago will use the spray or a placebo daily for up to 24 days. Researchers will monitor side effects and see if virtual training…

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

Researchers are testing whether combining transcranial random noise stimulation (tRNS) with neurofeedback can improve attention in adults who have sustained a brain injury from stroke, trauma, or lack of oxygen. Participants receive sessions that pair 10 minutes of tRNS with 20 m…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

Researchers at the University of Alberta are testing whether breathing pure oxygen for two minutes at a time can change sensation and movement in adults with long-standing, severe spinal cord injuries. The study enrolls 25 people aged 18 to 65 whose injuries occurred at least thr…

Researchers at the University of Louisville are studying children who have a cervical spinal cord injury that happened before or during birth. The study combines activity-based recovery training, which uses tasks like stepping and standing, with transcutaneous spinal cord stimula…

This study tests a small, home-use device that sends mild electrical pulses to a nerve in the leg (tTNS) to improve bladder control in 20 children with spina bifida who have neurogenic bladder. Half the kids will use the real device, half a sham device, for 30 minutes daily, 5 da…

This study tests whether simple exercises (like drinking water and breathing in a certain way) can improve sleep quality in 60 U.S. service members with obstructive sleep apnea. Some participants have also had a traumatic brain injury. The goal is to see if these exercises reduce…

This study tests whether injecting the steroid dexamethasone around the hip joint during surgery can reduce pain, nausea, and hospital stay for people with a broken hip. About 110 adults aged 50-90 having hip replacement for a femoral neck fracture will take part. The goal is to …

This trial tests whether a structured educational program, including an illustrated booklet, can improve recovery after hip fracture surgery. Participants are randomly assigned to receive the program plus routine care or routine care alone. The study measures functional independe…

Researchers at the University of Washington are testing whether non-invasive electrical stimulation of the spinal cord through the skin, combined with intensive physical therapy, can improve walking and standing in people with spinal cord injuries. The trial enrolls 20 adults wit…

This study looks at whether playing music of a patient's choice during wound dressing can lower stress and make the experience better. About 50 hospitalized adults will be randomly assigned to either listen to music or receive standard care. Researchers will measure heart rate, b…

This trial tests whether a computer navigation system called ADAPT helps surgeons place screws more accurately during hip fracture repair. About 96 adults aged 50-85 with certain hip fractures will be randomly assigned to receive surgery with or without the navigation system. The…

This trial tests whether extracorporeal shock wave therapy (ESWT), which delivers sound waves to painful areas, can ease symptoms of complex regional pain syndrome type I (CRPS-I) that sometimes follows a wrist fracture. Sixty adults with CRPS-I will receive standard rehabilitati…

This study compares three different wrist positions (bent back, straight, or bent forward) in a 3D-printed hand splint used after flexor tendon repair. About 64 people who had surgery on finger tendons will be randomly assigned to one of three splint positions and follow the same…

This study tests two ways to numb the arm for wrist fracture surgery in people at high risk for severe pain. One method uses a long-acting numbing drug (liposomal bupivacaine) plus regular bupivacaine, and the other uses a steroid (dexamethasone) plus regular bupivacaine. The goa…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This study tests whether taking a short chain fatty acid supplement can reduce gut-related side effects in people receiving radiation therapy for cancers in the abdomen or pelvis. About 122 adults will be randomly assigned to receive either the supplement or a placebo. The goal i…

This study tests whether taking high-dose branched chain amino acids (BCAAs) can help teens and young adults recover from a concussion more quickly. Researchers will compare recovery rates at 28 days between those taking BCAAs and those taking a placebo. The trial aims to enroll …

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study looks at whether a new type of nerve block, called the Quadro-Iliac Plane (QIP) block, helps people recover better after hip replacement surgery. Researchers will compare it to other standard blocks by measuring pain, how quickly people get up and move, and overall rec…

This study tests whether adding regional anesthesia, such as nerve blocks, to standard pain treatment can reduce opioid use and pain after pelvic or acetabular fracture surgery. Adults undergoing surgery for these fractures may receive ultrasound-guided nerve blocks with a long-a…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can improve thinking and memory in people still having symptoms 3 to 12 months after a mild concussion. Thirty adults will receive 10 sessions over about 3 w…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study tests a new type of talk therapy for veterans and service members who have both PTSD and a mild or moderate traumatic brain injury. The therapy focuses on relaxation, stress management, and problem solving instead of asking patients to relive their trauma. The goal is …

This phase 2 trial tests whether ketamine-assisted psychotherapy (KAP) can safely ease PTSD and trauma symptoms in adults with severe burns covering more than 15% of their body. Twelve participants will receive two KAP sessions plus a preparatory talk therapy session. The main go…

This pilot study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) in 20 adults with a history of childhood trauma and current suicidal thoughts. The therapy combines coping skills training with trauma-focused treatment to address both suicide risk and t…

This trial tests whether adding rhythmic auditory stimulation — like a steady beat — to dynamic neuromuscular stability exercises improves balance, body awareness, and performance in badminton players recovering from a lateral ankle sprain. About 44 players aged 18 to 30 with a r…

This trial explores whether combining cognitive training with a gentle electrical brain stimulation technique, called tDCS, can help improve working memory in people who have had a moderate to severe head injury. Participants will go through a 5-month program that includes memory…

This trial tests whether brief, controlled episodes of breathing lowered oxygen — similar to being on a tall mountain — can improve leg strength and reaction time in people with incomplete spinal cord injury. Participants will receive different doses of this low-oxygen therapy or…

This trial tests whether a 3-month, home-based walking program can improve thinking skills like memory and processing speed in adults with traumatic brain injury (TBI). Participants will either start walking right away or wait 3 months. The study focuses on safety and whether peo…

This trial compares intravenous (IV) acetaminophen to oral acetaminophen for managing pain and preventing delirium in adults aged 60 and older after hip fracture surgery. Participants receive either IV acetaminophen plus a placebo pill, or IV placebo plus oral acetaminophen, ever…

This study tests two types of ankle foot orthoses (AFOs) — advanced braces that store and release energy versus conventional ones — in veterans and warriors with lower limb injuries. Researchers will measure mobility, balance, and confidence in daily activities to see if the newe…

This study tests whether training the brain-to-muscle pathway using transcranial magnetic stimulation (TMS) can improve arm and hand movement in people with incomplete spinal cord injury. Participants will undergo 30 sessions where TMS is used to strengthen the connection between…

This study tests whether a therapist-guided exercise program helps people aged 50 and older recover better from a wrist fracture compared to usual care advice. Participants will either receive supervised exercises or standard self-management advice. The main goal is to see if the…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study tests whether early, symptom-guided therapy can prevent long-term complaints after mild traumatic brain injury. About 655 adults aged 18-70 will receive either physical/occupational therapy, psychoeducation by phone, or usual care. The goal is to reduce post-concussion…

This study tests whether taking creatine supplements after a concussion helps people recover faster. Twenty adults aged 18–35 with a recent concussion will either take creatine or follow their usual diet. Researchers will track how many days it takes to become symptom-free and co…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study tests whether adding robot-assisted arm and hand exercises to standard occupational therapy helps people with cervical spinal cord injury regain upper-limb function. Thirty participants will be randomly assigned to receive either standard therapy alone or standard ther…

This study tests whether electrical stimulation of the lower spinal cord, combined with rehabilitation, can help people with incomplete spinal cord injuries walk short distances and improve bladder and sexual function. Fourteen adults with stable, incomplete injuries will receive…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study looks at mothers who feel severe pain during a C-section despite spinal or epidural anesthesia. It compares giving general anesthesia versus extra pain medicine to see which better prevents post-traumatic stress disorder (PTSD). The goal is to find a way to reduce trau…

This study tests whether adding virtual reality (VR) exercises to standard physical therapy can improve hand function, reduce pain, and speed recovery in adults with traumatic wrist or hand injuries. About 40 participants will receive either usual rehab alone or usual rehab plus …

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether applying mild electrical stimulation to the skin over the spine, starting just 3 days after a traumatic spinal cord injury, is safe and might help patients recover movement. Fifteen adults with acute spinal cord injury will receive either real or sham sti…

This study tests whether hypnosis before getting stitches in the emergency room can lower pain and stress. 180 adults with stitchable wounds will either receive standard care or a short hypnosis session before the procedure. The main measure is heart rate variability, and patient…

This study tests two different therapies to help people with ongoing memory problems after a concussion. One is traditional cognitive rehabilitation, and the other is a new cognitive-behavioral therapy (CBT) approach. Researchers want to see which one works better for improving h…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study tests whether using RECELL® — a device that creates a spray from a patient's own skin cells — can improve skin color matching after head and neck reconstructive surgery. Twenty adults who need this surgery will receive the treatment, and their color match, healing, and…

This study tests whether strengthening the ankle, the hip, or both together works best for people with chronic ankle instability. 45 participants aged 18-35 will do isometric exercises three times a week for four weeks. Researchers will measure improvements in stability, strength…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This pilot study tests whether a daily 10-minute paced breathing exercise (inhale 4 seconds, exhale 6 seconds) can help children and teens aged 9-18 recover from a concussion. Twenty participants will either do the breathing exercises at home for four weeks or receive usual care.…

This study tests whether putting tranexamic acid (a medicine that helps blood clot) into the surgical wound before closing it can reduce pain and the need for painkillers after wrist fracture surgery. About 90 adults having surgery for a broken wrist will be randomly assigned to …

This study tests whether using CPAP or BiPAP breathing machines can reduce tumor movement during radiation therapy for lung cancer, esophageal cancer, or lymphoma. About 31 adults with advanced but treatable cancers will try these machines during treatment. The goal is to see if …

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with recent traumatic spinal cord injuries who are on a breathing machine. The goal is to see if this treatment is safe and feasible, and if it improves oxygen l…

This study tests whether a semi-elemental liquid diet (a pre-digested formula) reduces stomach and bowel issues like vomiting, diarrhea, and bloating in patients with severe traumatic brain injury. About 100 adults will receive either the special formula or standard liquid nutrit…

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants w…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests whether gentle chest vibration or breath focus exercises can reduce symptoms of dissociation in people who have experienced trauma. Researchers will measure changes in brain activity and self-reported symptoms over 8 sessions. The goal is to understand if these s…

This study tests a portable virtual reality system that guides eye exercises to help veterans with mild traumatic brain injury improve their eye coordination. About 80 veterans will be split into two groups: one receiving active therapy and the other a sham version. The goal is t…

This pilot study tests whether a topical diclofenac gel (Voltaren) works as well as oral ibuprofen for reducing pain in children aged 6-18 with ankle or knee sprains. Sixty participants will use either the gel or oral medicine three times a day for three days, then report their p…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study tests whether adding blue light therapy to standard wound care helps donor sites (the area where healthy skin is taken for grafting) heal faster in burn patients. About 25 adults with deep burns will have two donor sites: one treated with standard care alone, the other…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study tests whether non-invasive spinal stimulation, used at home with exercise, can safely improve arm and hand function in people with recent cervical spinal cord injury. 46 participants will be randomly assigned to start the program immediately or after a 12-week delay. T…

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether a nasal spray of fentanyl or ketamine can relieve moderate to severe pain from limb injuries in children (ages 2-17) faster than oral morphine. About 300 children in the emergency room will be randomly assigned to one of the three medicines. The goal is t…

This study looks at whether using special prismatic lenses along with computer brain games can help improve thinking and behavior in people who have had a traumatic brain injury. About 50 adults will take part, with half getting the lenses plus games and the other half getting ga…

This study tests whether breathing low oxygen, along with spinal cord stimulation and walking practice, can improve walking for people with chronic spinal cord injury. About 60 adults with some walking ability will take part. The goal is to see if these combined treatments can he…

This study tests whether using a blood flow restriction (BFR) cuff during physical therapy helps people recover better after ankle ligament reconstruction surgery. About 105 adults will be split into two groups: one gets standard therapy, the other adds BFR. Researchers will meas…

This study is testing whether adding a sensor-based device to standard physical therapy can improve both thinking and movement in frail older adults recovering from hip fracture surgery. Thirty participants aged 65-89 will use the device for part of their rehab. The goal is to se…

This study tests whether a long-acting form of the anesthetic bupivacaine, combined with regular bupivacaine, can control pain better than the standard drug ropivacaine after hip replacement. Sixty adults with hip fractures or necrosis will receive one of the two treatments via a…

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests whether using ultrasound to guide a numbing injection (hematoma block) works better than the traditional method of injecting without imaging for people with a broken wrist. About 115 adults in the emergency department will take part. The goal is to see which appr…

This study looks at whether starting physical therapy soon after surgery for a specific knee fracture (tibial spine avulsion) helps people recover better than waiting longer. It includes 56 people aged 15-25 who had the surgery. Researchers will measure knee movement, muscle stre…

This study tests a structured rehabilitation program for active-duty soldiers who have had a mild traumatic brain injury (concussion). The program includes low-intensity aerobic exercise, balance, and cognitive activities tailored to each soldier's symptoms and job demands. Resea…

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study tests whether adding psychological coaching to standard care helps people with a broken shoulder recover better. It includes 70 adults who had surgery for a proximal humerus fracture and score high on a neuroticism test. Participants receive focused cognitive behaviora…

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study tests a guided online version of cognitive behavioral therapy for insomnia in 80 people who have had a moderate or severe traumatic brain injury at least a year ago and currently have insomnia. Participants will either receive the online therapy (6 modules over 6-9 wee…

This study looks at whether core stabilization exercises can improve hand function and emotional health in men recovering from traumatic hand injuries. Fifty-one men aged 20-50 will be split into three groups: standard hand rehab alone, standard rehab plus supervised core exercis…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests whether a gentle brain stimulation technique called tDCS can improve motor and thinking skills in children aged 10-15 who have had a mild concussion. Ten participants will receive tDCS and be evaluated with balance, coordination, and brain imaging tests. The goal…

This study is testing a non-invasive device called PNRT that uses gentle light and motion to help people with lingering dizziness and other symptoms after a mild traumatic brain injury. Researchers will enroll 80 adults to see if the device is safe, tolerable, and can reduce dizz…

This study compares standard radiation therapy to a newer method called dose painting for people with head and neck cancer. The goal is to see if dose painting causes fewer severe mouth ulcers one year after treatment. About 100 participants will be randomly assigned to receive e…

This study tests whether a guided therapy using psilocybin (the active ingredient in magic mushrooms) can safely help US Veterans with PTSD. Fifteen participants will receive two psilocybin sessions combined with talk therapy. The goal is to reduce PTSD symptoms and improve long-…

This study tests a bilingual program called 1stBIEN for Hispanic children (ages 3-17) recovering from traumatic brain injury. The program provides in-person education, mobile videos, and a navigator to help families access outpatient care and school support. Researchers will meas…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with computer-based brain games can improve attention, memory, and decision-making in veterans aged 65 and older who have had a mild traumatic brain injury. Participants will do exercises from home …

This study tests a new rehab program called STAR-C for people with lasting cognitive issues after a mild traumatic brain injury (concussion). It compares three groups: in-person therapy, online therapy via telehealth, and a waitlist that gets no treatment. The goal is to see if S…

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This study looks at how people with moderate to severe traumatic brain injury (TBI) walk and navigate in complex, real-life-like virtual environments, such as streets with other people. Researchers want to understand the specific difficulties these individuals face during everyda…

Researchers at a hospital in Iraq are studying whether a chest injury scoring system can predict which trauma patients will die or need intensive care. The study enrolls about 166 patients over age 16 who arrive at the emergency department with chest trauma. Doctors score each pa…

This study looks at how well people recover 12 months after an Achilles tendon rupture treated without surgery, using a specific rehabilitation program called the SMART protocol. Researchers will measure ankle strength with a machine and ask participants about their daily functio…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

Researchers at Xiangya Hospital are building a tool that uses several types of brain monitoring to predict whether patients with severe acute brain injury will be awake, comatose, or deceased 90 days after ICU admission. The study enrolls 200 adults aged 18 to 80 with conditions …

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study is a registry that will collect information from about 200 people who receive a total jaw joint (TMJ) replacement. Researchers will track their health, jaw function, and any complications for up to 5 years after surgery. The goal is to learn more about how these replac…

This study tests whether an AI tool called LuAna helps doctors find lung problems in chest X-rays more accurately than doctors working alone. About 1,470 adults with breathing issues will have their X-rays read first by doctors, then with AI support. The goal is to see if AI boos…

This study follows 1,000 caregivers and their high-risk infants who use the SNOO Smart Sleeper Bassinet at home. Researchers will track any serious injuries or deaths linked to the device to see how safe it really is. The goal is to gather real-world safety data for babies at hig…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study tests whether short episodes of breathing low-oxygen air can improve breathing strength in people with chronic spinal cord injury. Participants will try three different breathing sessions (low oxygen, low oxygen with extra carbon dioxide, and normal air) to see which w…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

Researchers are studying the bacteria that live in burn wounds and how they relate to patient outcomes. The trial compares standard laboratory cultures with next-generation DNA sequencing to see if the newer method gives a clearer picture of the wound microbiome. Up to 400 adults…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to learn about its safety and how it works in the body. Participants will help researchers understand if the device is promising for future use.

Researchers are studying how aging and spinal cord injury affect two nerve pathways that help control leg movement: the corticospinal and reticulospinal tracts. The trial enrolls adults with chronic spinal cord injury and healthy controls. Participants receive transcranial magnet…

Researchers at a French hospital are interviewing girls and young women aged 12 to 25 who receive care in child and adolescent psychiatry and who view pornographic content. Through semi-structured interviews, the study explores when and how participants first encountered pornogra…

This study looks at how cannabidiol (CBD) influences stress in 160 people aged 18-25 who experienced early life trauma. Participants receive either CBD or a placebo, then undergo brain scans and stress tests. The goal is to understand the brain and hormone changes behind CBD's st…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

Women with spinal cord injury often deal with urinary incontinence, but most research has focused on women after menopause. This pilot study asks whether the natural drop in estrogen after ovulation could make incontinence more frequent. Twenty-four women will track their menstru…

Researchers at Lille University are following 350 people, including cancer patients recently diagnosed with breast, gynecological, testicular or digestive cancer, their caregivers, and healthcare professionals. Over one year, participants answer questionnaires about post-traumati…

This study looks at whether unconscious patients with brain injuries who show brain activity in response to music and language on an EEG are more likely to wake up and recover. Researchers will monitor 300 adults in the ICU, along with healthy volunteers, to see if these brain si…

This study looks at 40 veterans with chronic spinal cord injury to find any remaining nerve connections below their injury. Researchers will use MRI scans and non-invasive stimulation to measure these connections. The goal is to understand who might benefit from future treatments…

This study is creating and testing a Turkish version of a questionnaire that measures how people recover from ankle fractures. Researchers will ask 150 adults with ankle fractures to fill out the new Turkish questionnaire along with two other standard forms. The goal is to make s…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study is testing whether a mobile health app system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and wellness. About 160 participants will use the app for one yea…

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …

This study is building a detailed collection of medical information and biological samples from 105 people with spinal cord injury. Researchers will track how injuries change over time, what complications arise, and how the body responds. The goal is to create a research platform…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

Researchers are studying how severe burn injuries change the body's ability to control temperature during work and rest in a hot environment. The trial compares burn survivors with healthy adults, measuring core temperature and heart rate during these cycles. The goal is to under…

This study is looking at 800 veterans to see if mild traumatic brain injury (concussion) increases the risk of dementia later in life. Researchers will test memory, brain waves, brain scans, and proteins in blood and spinal fluid. The goal is to find early warning signs of diseas…

This study aims to build a large database of information from cancer patients receiving standard radiotherapy. By systematically collecting clinical details, patient-reported outcomes, and imaging data, researchers hope to better understand radiation effects and long-term outcome…

This study follows 185 adults in the Netherlands who are hospitalized with serious trauma injuries. Researchers will ask them to fill out short questionnaires about their quality of life, pain, fatigue, and daily functioning at several points over a year. The goal is to see wheth…

This study looks at adults who had a traumatic brain injury at least a year ago. Researchers want to see whether those with growth hormone deficiency have worse quality of life, fatigue, mood, and sleep than those without it. Participants complete questionnaires and a test for gr…

This study will test a new way to assess concussion in football players by having them perform cognitive and motor tasks right on the field, like counting whistles while dribbling. Researchers aim to standardize these 'ecological' tests so they can be used as a baseline before th…

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and c…

This study explores whether measuring the natural variability in a person's breathing can help predict complications after lung surgery. Researchers will use a sensor belt to continuously monitor chest movements in patients undergoing lung resection, both before anesthesia and af…

This study looks at whether certain biological signs—like genetic markers, blood chemicals, and heart rate patterns—can predict who will recover well from a wrist fracture and who might develop chronic pain or a condition called Complex Regional Pain Syndrome. Researchers will al…

This study looks at whether the bacteria in your gut can help predict who might experience side effects from stereotactic radiosurgery (SRS), a precise type of radiation used to treat brain tumors. Researchers will collect stool and blood samples from 150 patients before and afte…

This study looks at whether doctors can rely on feeling a patient's pulse (in the neck, groin, or wrist) to know if their blood pressure is dangerously low during shock. Researchers will compare pulse checks with standard blood pressure readings in 5,000 critically ill adults in …

This study tests a special method of removing the breathing tube after abdominal surgery to prevent lung problems. It involves 270 adults at moderate or high risk of lung complications. The goal is to see if a protective extubation approach is practical and followed correctly by …

This study aims to understand and improve fertility in men with spinal cord injury. Researchers will collect and analyze semen samples from participants to assess sperm count, motility, and other factors, and correlate these with patient characteristics. The goal is to help men w…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This study is a large registry that tracks cancer patients who receive both radiotherapy and molecular therapies, such as immunotherapy. The goal is to better understand how these two treatments interact and to identify how often severe side effects occur. By collecting data from…

This study explores whether two computer-based tasks can measure decision-making fatigue in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will compare results from TBI patients with those from healthy volunteers to see if the tasks are practical…

This study looks at whether vitamin D levels in the blood and cervical fluid before treatment can predict how well chemoradiotherapy works for locally advanced cervical cancer. Researchers will measure vitamin D in 100 women undergoing standard treatment and track their response …

This study looks at why some older adults with serious conditions like cancer or fractures become vulnerable or frail. Researchers will follow about 1500 patients to find out how common different causes of vulnerability are and how they affect outcomes like survival and quality o…

This study follows 100 people with advanced gum disease (Stage III or IV) who undergo regenerative periodontal surgery. Researchers track how the surgical site heals in the first one to two weeks and then check whether that early healing pattern relates to gum health and bone cha…

This observational study tracks 7,000 men and women with cancer to see how treatments like chemotherapy, radiation, and immunotherapy affect fertility. In women, researchers measure a hormone called AMH to gauge ovarian reserve; in men, they analyze sperm quality. The goal is to …

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This pilot study tests whether StimolIrpinia, a multimedia collection of local images, videos, and cultural information, can support cognitive rehabilitation in people with severe acquired brain injury. Ten hospitalized patients will use the tool in six 30-minute sessions over tw…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study looks at two different methods for setting the pressure on a breathing machine (ventilator) in people with a serious lung condition called ARDS. The goal is to see which method improves oxygen levels better over 24 hours. About 52 adults with moderate to severe ARDS wi…

This study follows 500 children aged 8-17 who have had a concussion within the past week. Researchers track their symptoms, fatigue, social interactions, thinking skills, school needs, and biological markers like saliva inflammation and puberty hormones over a year. The goal is t…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study looks at whether a new blood test can help emergency room doctors better assess patients with mild traumatic brain injury (TBI). The test checks for brain injury markers in the blood and may reduce the need for CT scans. Researchers will study how well the test works i…

This study collects and stores brain tissue from adults who have had a traumatic brain injury and require surgery to remove a bruise on the brain. Researchers will analyze the tissue to understand the molecular and cellular processes involved in brain damage and repair. The goal …

This study looks at whether starting body-weight-supported treadmill training (BWSTT) at different times within the first 6 months after a spinal cord injury affects walking ability. 108 participants will be randomly assigned to start therapy within 60 days, 3 months, 6 months, o…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study looks at whether two different training programs can improve emotional health in people who have had a moderate to severe traumatic brain injury. About 48 adults will take part in 8 one-on-one sessions over a month, learning either to recognize emotions or adopt health…

This study compares brain health in 300 former professional football players (ages 29-59) to a similar group of men who did not play football. Participants will undergo cognitive tests, balance and eye-movement exams, sleep assessments, and high-resolution MRI scans. The goal is …

This study looks at whether a harmless thermal camera can help doctors see how surgical wounds are healing after skin surgery. About 120 adults having skin lesions removed will have their wounds photographed with the camera. The goal is to catch problems like infection or slow he…

This study compares carbon dioxide emissions from orthopedic surgeries performed with different materials and setups. Researchers will track waste, energy use, and sterilization methods for procedures like carpal tunnel release or wound revision. The goal is to identify ways to r…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study is testing whether a new 3D ultrasound system can help people with blood vessel disease better understand their condition. Researchers will give 270 patients a 3D image of their blocked or narrowed vessels instead of the usual hand-drawn sketch. They want to see if thi…

This study follows about 400 young rugby players (ages 12-18) from Rugby Club Toulonnais over two seasons. Researchers will record every injury that needs medical care, noting how often injuries happen, how serious they are, and what types occur. The goal is to understand injury …

This study looks at how a serious burn injury changes the way cells produce energy. Researchers will collect blood, urine, and tissue samples from 125 children and adults admitted to the burn center. No new treatments are tested; the goal is simply to learn more about the body's …

This study looks at blood from people with ARDS, a severe lung condition with no specific medicines. Researchers will take immune cells from the blood and test a new blocking agent in the lab to see if it can reduce lung damage. The goal is to learn more about the disease and fin…

This study looks at two ways to treat pelvic fractures in people aged 60 and older: surgery or non-surgical care. Researchers will follow 120 patients to see if a larger trial comparing these treatments is possible. The goal is to understand patient and surgeon preferences and wh…

This study uses special MRI scans to look at how well a donated kidney works in the recipient and how the donor's remaining kidney adapts over one year. It includes 80 adults (donors and recipients) and aims to help doctors choose the best kidneys for transplant. The goal is to b…

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study will use data from 1,200 hip fracture patients to build a machine learning model that predicts mobility and daily living independence three months after injury. The goal is to help patients and doctors set realistic expectations for recovery. No new treatments are bein…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study tests whether a simple manual chest compression technique works as well as electrical impedance tomography (a special imaging method) to find the best ventilator pressure for people with acute respiratory distress syndrome (ARDS). Thirty adults on ventilators will have…

This study is observing nearly 2,700 active-duty service members to find out what makes them more likely to get muscle or bone injuries. Participants will do physical tests and answer questions to identify risk factors. The goal is to create better ways to prevent injuries and he…

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study looks at whether surgery improves walking in older adults with pelvic ring fractures. Researchers will compare walking patterns and hospital outcomes between those who get surgery and those who don't. The goal is to see if surgery leads to better recovery and quality o…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study follows 150 adults who need surgery for a broken upper arm bone (proximal humerus fracture) using the ALPS plating system. Researchers will measure shoulder strength, movement, and pain, and track any complications. The goal is to see how well this surgical tool perfor…

This study aims to translate and culturally adapt the Groningen Frailty Indicator (GFI) questionnaire for Greek patients with hip fractures. Researchers will enroll 89 adults over 65 who are undergoing hip fracture surgery. The goal is to create a reliable Greek version of the GF…

This study looks at adults aged 18-70 who have a specific type of broken back (thoracolumbar burst fracture) but no nerve damage. Half will get surgery to fuse the spine, and half will wear a brace for six weeks instead. Researchers want to see if avoiding surgery works just as w…

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study looks at whether people with a torn ACL have weakness in the soleus, a calf muscle that helps protect the knee. Researchers will test leg strength in 55 participants with ACL tears and compare them to healthy individuals. The goal is to better understand muscle changes…

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep with a movement monitor and ask participants about their daily life and mental health. The goal is to unde…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if it can quickly detect problems that could lead to paralysis. About 120 adults having planned aortic repair will take part. I…

This study looks back at the last 10 years in Denmark to understand how many people use breathing machines at home through a tube in their windpipe. Researchers will track which diseases lead to this need and how many patients survive one year after starting. The goal is to spot …

This study looks at how spinal cord injury changes the gut's nervous system and intestinal barrier. Researchers will take colon biopsies from 40 people with spinal cord injury and compare them to healthy controls. The goal is to understand gut problems after injury and find possi…

This study looks back at medical records of 5,000 adults who had blunt trauma to the chest or belly area. Researchers want to learn how often the adrenal gland is injured and how that affects recovery. The goal is to better understand this rare injury, not to test a new treatment…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This study looks at whether wearing a rigid neck collar is needed for stable neck fractures. About 616 adults with these fractures will be treated either with a collar for 12 weeks or without one. The goal is to see if both approaches lead to similar healing, while avoiding colla…

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This study looks at whether online driver training can help reduce crash risk for new teen drivers. Researchers will enroll 1,300 adolescents aged 16-17 in Pennsylvania who have a learner's permit. Participants will complete online safety education or skills training, and their d…

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This study looks at whether it's safe and satisfying to shower early after orthopedic fracture surgery, compared to waiting longer. About 56 adults with arm or leg fractures will be randomly assigned to bathe early or follow the traditional delayed approach. The goal is to see wh…

This study measures how loose the knee is during surgery for ACL reconstruction, ACL revision, or meniscus transplantation. Researchers use a navigation system and a special device to track knee movement in real time. The goal is to gather data that may help improve surgical tech…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study is collecting information from 760 adults who receive ERISMA or Idys spine implants during surgery. Researchers will track complications, pain levels, and quality of life for two years after the procedure. The goal is to confirm the devices are safe and work well in ev…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study looks at two different methods to check consciousness in people with severe brain injuries. The goal is to see if a shorter, simpler test works as well as the longer standard one. About 110 patients will take part, and the results could help doctors make better treatme…

This study looks at how glucose spreads in the body of adults with severe burns (covering at least 30% of their skin). Researchers will measure glucose levels after a small injection over the first four days. The goal is to see if this measurement can help guide fluid treatment i…

This observational study tracks 500 lung cancer patients receiving a second round of high-dose radiation to the chest. Researchers will collect data on side effects and survival to find safer ways to deliver repeat radiation. The goal is to help doctors personalize treatment and …

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study checks how well a tool called the STUMBL score predicts serious outcomes like death or ICU need in people with blunt chest injuries (from car crashes or falls). About 188 adults in Iraq will be scored when they arrive at the ER, and their results will be tracked. The g…

This study tests whether a simple procedure called remote ischemic preconditioning (RIPC) — briefly restricting blood flow to an arm or leg — can reduce brain injury after non-cardiac surgery. The trial will include 216 older adults at risk for postoperative delirium. Researchers…

This study will enroll 200 multiple trauma patients at a trauma center in Iraq to see which of two scoring systems—the Revised Trauma Score (RTS) or the MGAP score—better predicts who will die or have complications. Patients will be scored upon arrival and followed during their h…

This study looks at how a concussion (mild traumatic brain injury) before age 6 might change brain structure and behavior. Researchers will use MRI scans to compare 30 children who had a concussion with 30 children who had a limb injury. The goal is to better understand the short…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This study compares two scoring systems, MGAP and GAP, to see which better predicts outcomes like death, hospital stay length, and need for surgery in people with multiple injuries. About 522 adults with trauma will be scored when they arrive at the emergency department, and thei…

This observational study looks at how acquired brain injury affects speech and breathing in adults with dysarthria. About 100 participants will have their voice recorded and take breathing tests. The goal is to find better ways to identify the severity and type of dysarthria, hel…

This study explores whether breathing slightly higher levels of carbon dioxide (CO2) can safely increase the movement of proteins from the brain into the blood, which may indicate better waste clearance. Researchers will compare healthy adults and those with a history of traumati…

This study aims to understand how upper-limb assistive devices—like grasping gloves, mealtime aids, and robotic arms—impact the daily lives of people with motor impairments. Researchers will interview and survey 150 regular users (including those with stroke, spinal cord injury, …

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study looks at whether a single dose of estradiol (a hormone) can reduce the number of intrusive, unwanted memories that form after a traumatic event. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The go…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study aims to understand how muscles change over time in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size, length, and quality in 229 children. The goal is to link these changes to brain injury and treatments, helping improve fu…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.

This study is collecting information from 11,000 people who have had a heart attack or heart muscle injury. Researchers want to learn more about these conditions to improve future treatment. The study does not test a new drug or procedure, but instead gathers data to better under…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at whether a blood test marker called Monocyte Distribution Width (MDW) can help predict complications and survival in elderly patients with hip fracture. Researchers will follow 100 patients aged 65 and older, measuring MDW and other inflammatory markers at admi…

This study follows 1,000 adults with diabetic foot ulcers for up to 5 years to learn why some have worse outcomes, including death. Researchers will track health events and build a risk score to identify those most at risk. The goal is to better understand the disease and improve…

This observational study tracks 200 adults with severe burns (over 30% of body surface) to see if giving albumin in the first 24 hours after injury improves outcomes. Researchers will measure death rates, kidney failure, and severe lung problems within 28 days. The goal is to gat…

This study aims to improve emergency care for injured children in Tanzania by finding and fixing delays in the healthcare system. Researchers will work with local clinics and hospitals to create a better triage process, helping kids get the right care faster. About 284 patients, …

This study looks back at the records of 4,500 adults with mild head injuries treated in emergency rooms in the Emilia-Romagna region of Italy. Researchers want to see how often serious complications like brain bleeding occur and compare two common rules doctors use to decide if a…

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This study tests whether combining non-invasive brain and spinal cord stimulation during a movement task can improve hand function and thinking in people with stroke or spinal cord injury. 45 participants will receive both types of stimulation separately and together to see if th…

This study follows 150 adults for one year after ankle arthroscopy to record any complications that arise. Participants will be checked by their surgeon and physical therapist at 15 days, 3 months, 6 months, and 1 year after surgery. They will also fill out questionnaires and do …

This study follows 30 adults with severe burns to see how their gut bacteria change over time. Researchers collect stool samples and measure inflammation and other health markers. The goal is to understand how these microbiome shifts relate to recovery, not to test a new treatmen…

This study looks at whether the Iowa Level of Assistance (ILoA) scale is a reliable tool for measuring functional recovery in patients after joint replacement surgery. Researchers will have multiple physiotherapists assess the same patients to see if their scores agree. The goal …