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Can discarded bone reveal the secrets to stronger bones?

NCT ID NCT05732870

Knowledge-focused Sponsor: Relation Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing the cells and genetics in these samples, they hope to identify new targets for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Relevant orthopaedic surgery (collection of discarded bone waste and blood for analysis)
What this could lead to
If successful, this could identify new drug targets for preventing or treating bone diseases like osteoporosis and osteoarthritis.
What could go wrong
This is an observational study, not a treatment trial. It will take years to analyze data, and findings may not lead to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Dec 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants undergoing range of orthopaedic surgeries.

Ages

18 to 110 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint (including hip, knee, shoulder, wrist, elbow, ankle). 2. Patient with fractured neck of femurs undergoing hemiarthroplasty or total hip arthroplasty, or other internal fixation procedure. 3. Patients undergoing acute low-velocity or fragility fracture fixation surgery. 4. Patients aged between 18-110 years old with capacity to consent. Since deteriorating bone health including diseases like osteoporosis are primarily conditions of older age there is no practical upper age-limit. However, study involvement is limited by suitability for surgery which encompasses multiple factors considered on an individual case basis including age, frailty, comorbidities, baseline mobility, renal function and ability to consent (for instance due to dementia or delirium). We note that our inclusion criteria is purposefully broad as we aim to deduce trends across a wide range of conditions and backgrounds. Exclusion Criteria: 1. Patients unable to provide informed consent. 2. Patients with suspected/established underlying malignancy. 3. Patients with suspected/established osteomyelitis. 4. Patients with suspected/established bloodborne disease 5. Patients who are currently a subject of a clinical trial involving an investigational medicinal product.

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Conditions

The condition(s) this trial relates to.

bone disorder bone fracture bone marrow disorder osteoarthritis osteoporosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone diseases Bone fracture Bone marrow disease Osteoarthritis Osteoporosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Barts Health NHS Trust

    RECRUITING

    London, United Kingdom

  • Chase Farm Hospital

    RECRUITING

    London, United Kingdom

  • Fitzrovia Hospital/QASMC

    RECRUITING

    London, United Kingdom

  • Harley Street Specialist Hospital

    ACTIVE_NOT_RECRUITING

    London, Greater London, W1G 8HU, United Kingdom

  • King's College Hospital

    NOT_YET_RECRUITING

    London, United Kingdom

  • Luton & Dunstable University Hospital

    ACTIVE_NOT_RECRUITING

    London, United Kingdom

  • Royal National Orthopaedic Hospital NHS Trust

    NOT_YET_RECRUITING

    London, United Kingdom

  • West Middlesex University Hospital

    RECRUITING

    London, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.