Bone disorder

Researchers are testing a new cell therapy called anti-FLT3 CAR-T (HG-CT-1) in adults and children with acute myeloid leukemia (AML) that has come back or stopped responding to standard treatment. The study is a Phase 1 dose-escalation trial, meaning its first goal is to find out…

Researchers test whether adding venetoclax to a standard conditioning regimen called FLAMSA-treosulfan is safe for people with high-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or secondary acute myeloid leukemia who are receiving a donor blood stem cell trans…

Older adults with acute myeloid leukemia (AML) often fare poorly with chemotherapy alone, and a stem cell transplant can offer better long-term survival but carries a high risk of transplant-related death. Researchers are comparing two drug combinations given before a haploidenti…

Myelofibrosis is a bone marrow disease that can lead to leukemia. A stem cell transplant from a matched donor can cure it, but many patients cannot find a match. This trial tests a new transplant protocol using half-matched family donors, with a special drug regimen before transp…

This trial compares different surgical and antibiotic approaches to treat infections in artificial hip and knee joints. It tests whether cleaning the joint while keeping the implant in place (DAIR) or replacing the joint entirely leads to better cure rates. It also examines wheth…

This study tests a new approach to prevent leukemia from coming back after a stem cell transplant. It uses donor T cells that have been engineered to recognize and attack a specific target (HA-2) on leukemia cells. The trial enrolls adults with acute myeloid leukemia (AML) or mye…

This early-stage trial tests two oral drugs, ziftomenib and quizartinib, together in adults with relapsed or hard-to-treat acute myeloid leukemia (AML) that has certain genetic markers. The goal is to find a safe and effective all-pill treatment for common AML subtypes. About 44 …

This study tests whether two drugs, venetoclax and revumenib, can control minimal residual disease (MRD) in people with acute myeloid leukemia (AML). MRD means small numbers of cancer cells remain after initial treatment, raising the risk of relapse. The trial enrolls about 8 par…

Researchers are testing whether adding an experimental drug called RVU120 to venetoclax can help adults with acute myeloid leukemia (AML) that has come back or stopped responding to earlier venetoclax-based treatment. The trial enrolls about 98 adults who have already failed a hy…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This study tests whether adding the drug venetoclax to standard chemotherapy can better treat acute myeloid leukemia (AML) that is newly diagnosed or has come back. About 116 adults with AML or high-risk MDS will receive the combination. The goal is to see if the combo improves r…

This phase II trial tests whether adding gilteritinib to the usual two-drug therapy (azacitidine and venetoclax) can help older or frail adults with a specific type of acute myeloid leukemia (FLT3-mutated) achieve deeper remission. About 147 participants will be randomly assigned…

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

This phase II trial is testing whether adding the drug venetoclax to standard chemotherapy can improve remission rates in younger patients with intermediate-risk acute myeloid leukemia (AML). About 153 participants will receive either standard chemo or a combination with venetocl…

This study tests a new oral drug, QTX-2101, combined with standard ATRA therapy for adults newly diagnosed with a low-risk form of acute promyelocytic leukemia (APL). The goal is to see if the oral capsule works as well as the current intravenous treatment. About 150 participants…

This phase 2 trial is testing a combination of five drugs (fludarabine, cytarabine, filgrastim-sndz, gemtuzumab ozogamicin, and idarubicin) in 270 people with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome that have specific genetic changes. The goal…

This phase 2 trial tests whether the drug olverembatinib can safely control chronic myeloid leukemia (CML) in people who are newly diagnosed. About 50 adults will take the drug by mouth. Researchers will track side effects and how well the drug works. The study is currently recru…

This study tests whether giving donor white blood cells (lymphocytes) soon after a stem cell transplant can lower the chance of cancer returning in people with high-risk blood cancers like leukemia or lymphoma. Participants receive chemotherapy, a stem cell transplant, and then a…

This early-stage study tests a new drug, PRT12396, in about 100 people with polycythemia vera or myelofibrosis—rare blood cancers. The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the drug controls the disease, but this …

This phase II trial tests whether adding enasidenib to standard ASTX727 and venetoclax improves remission rates in older adults (or younger unfit patients) with newly diagnosed IDH2-mutated acute myeloid leukemia (AML). About 93 participants will be randomly assigned to receive e…

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink advanced squamous cell cancers of the nasal cavity and sinuses better than chemotherapy alone. About 35 adults with newly diagnosed, untreated stage II to IVb disease …

This study tests an oral drug called pacritinib in people aged 12 and older with myelodysplastic syndromes (MDS) or related blood cancers (MDS/MPN). The goal is to find the best dose and see if it can shrink or control the disease. Participants take capsules twice daily for up to…

This early-phase trial tests a personalized treatment for people with blood cancers like leukemia. Doctors take a patient's own T cells, modify them in the lab to recognize unique cancer mutations, and infuse them back after a short course of chemotherapy. The goal is to see if t…

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This phase II trial tests several experimental drug combinations against the standard treatment for high-risk acute myeloid leukemia (AML) in patients aged 59 or younger. The goal is to see if newer regimens, including venetoclax and liposome formulations, can better shrink cance…

Researchers at a Korean hospital are following 210 adults who receive a cementless total hip replacement using the collarless Actis femoral stem. The study focuses on Asian patients, who tend to be younger at surgery and more often need the operation because of lost blood supply …

This early-stage trial is testing whether two drugs that lower metal levels in the body can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) respond better to chemotherapy. The study will enroll 58 adults and aims to find the safest dose and check f…

This phase 3 trial tests whether adding pelabresib to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. About 460 adults who have not taken JAK inhibitors before will receive either the combination or a …

This trial tests an experimental drug called DDY391 in about 220 adults with moderate to severe psoriatic arthritis, a condition that causes joint pain, swelling, and skin patches. Researchers want to see whether DDY391 can reduce joint symptoms better than a placebo and at what …

This study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …

This study tests whether giving a chemotherapy drug (decitabine) plus a targeted therapy (ruxolitinib, fedratinib, or pacritinib) before a stem cell transplant helps people with advanced myeloproliferative neoplasms (MPN) get to transplant and have better outcomes. About 25 adult…

This phase I trial tests a new treatment for adults with acute myeloid leukemia (AML) who have minimal residual disease (MRD) — small amounts of cancer cells that remain after standard therapy. The treatment uses the patient's own T cells, genetically modified to recognize a prot…

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. Th…

Researchers are testing an experimental drug called GenaKumab in children and teens with active systemic juvenile idiopathic arthritis, a condition that causes joint inflammation and recurring fevers. The trial enrolls about 290 participants aged 2 to under 18 who have had sympto…

This trial tests whether fospropofol disodium, a newer form of propofol, can improve the surgical field quality during endoscopic sinus surgery compared to standard propofol anesthesia. The study includes adults aged 18-65 with chronic rhinosinusitis who are scheduled for sinus s…

This large phase 3 trial is testing whether a new formulation of two chemotherapy drugs (CPX-351) and a targeted drug called gilteritinib can improve outcomes for children and young adults with newly diagnosed acute myeloid leukemia (AML). The study compares these new approaches …

This phase 2 trial tests whether adding the targeted drug venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The study aims to see if this combination can reduce the amount of c…

This early-phase trial tests a two-step approach for people with acute myeloid leukemia or related blood cancers that have returned or not responded to treatment. First, patients receive intensive chemotherapy (CLAG-M or FLAG-Ida) followed immediately by a reduced-intensity stem …

This phase 3 trial will test whether adding the drug quizartinib to the standard two-drug combination (venetoclax and azacitidine) helps adults with newly diagnosed acute myeloid leukemia (AML) live longer. The study includes 376 people aged 18 and older who cannot receive intens…

This early-stage study tests an experimental oral drug, AJ1-11095, in about 76 adults with myelofibrosis (a type of bone marrow cancer) whose disease has stopped responding to standard JAK2 inhibitor therapy. The main goals are to check the drug's safety, find the best dose, and …

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This study tests whether giving high-dose ruxolitinib and busulfan before a stem cell transplant can reduce spleen size and help the transplant work better in people with myelofibrosis. About 30 adults aged 18 to 75 with an enlarged spleen and a matched donor will take part. The …

This study tests two different doses of the drug quizartinib as a maintenance therapy for adults with a specific type of acute myeloid leukemia (FLT3-ITD positive) who are in their first complete remission after initial treatment and have not had a stem cell transplant. The goal …

This trial tests whether nicorandil, a drug currently used for heart conditions, can reduce disease activity and symptoms in people with rheumatoid arthritis. About 70 adults with moderate-to-severe RA will take either nicorandil or a placebo twice daily for three months, while c…

This study tests an oral drug called revumenib in people with certain types of leukemia that have relapsed or not responded to standard therapy. The trial has two parts: first, finding the best dose, then testing that dose in four groups based on leukemia type. About 447 particip…

This study tests a drug called ponatinib in 50 adults with chronic myeloid leukemia (CML) whose cancer did not respond to or they could not tolerate other targeted therapies. The goal is to see if ponatinib can control the disease by blocking a protein that helps cancer cells gro…

This Phase 3 trial tests an oral drug called nizubaglustat (AZ-3102) in people aged 4 and older with Niemann-Pick type C disease, GM1 gangliosidosis, or GM2 gangliosidosis. The study lasts 18 months and compares the drug to a placebo to see if it is safe and can slow disease prog…

This early-phase study tests a new type of immune therapy for people with certain blood cancers (leukemias) that have returned or not responded to standard treatments. The therapy uses the patient's own T cells, which are modified in the lab to recognize and attack cancer cells c…

Researchers are testing a new once-weekly injection called NNC0487-0111 in about 400 Japanese adults with overweight or obesity. Half the participants receive the drug and half receive a placebo, assigned by chance. The main goal is to measure how much body weight changes over th…

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

This study tests a new mix of drugs for people newly diagnosed with a specific type of acute myeloid leukemia (AML). The treatment combines a targeted drug (venetoclax) with two chemotherapy drugs, then switches to another chemo drug plus venetoclax. The goal is to see if this ap…

This study tests whether adding two targeted drugs, blinatumomab and venetoclax, to standard chemotherapy can improve outcomes for infants with a type of leukemia called acute lymphoblastic leukemia (ALL). About 153 infants will participate. The goal is to see if these combinatio…

This study is for people with a high-risk type of leukemia called CMML. It tests a stronger chemotherapy combination (including thiotepa) given before a stem cell transplant from a donor. The goal is to see if this approach helps patients live longer without the cancer coming bac…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study tests an experimental drug called CGT9486 (bezuclastinib) in people with advanced systemic mastocytosis, a rare and serious blood disorder. The drug aims to control the disease by blocking a key protein that drives abnormal mast cell growth. About 140 adults with aggre…

This study tests whether adding pivekimab sunirine to the standard drugs venetoclax and azacitidine helps adults with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. About 660 participants will be randomly assigned to receive ei…

This early-stage trial tests a personalized cell therapy called lifileucel for people with advanced uveal melanoma (a rare eye cancer) or certain sarcomas (connective tissue cancers). The treatment involves removing immune cells from the patient's tumor, growing them in a lab, an…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This early-phase trial is testing a combination of two drugs—Hyper-CVAD chemotherapy and venetoclax—in 22 children and young adults whose leukemia has returned or not responded to treatment. The main goal is to find a safe dose and monitor side effects. If the combination proves …

This study tests an experimental drug called DISC-0974 in about 150 adults with myelofibrosis or myelodysplastic syndrome (MDS) who also have anemia. The goal is to see if the drug can reduce the need for blood transfusions and increase red blood cell levels. The study is in earl…

This early-stage trial is testing an experimental drug called AMX-883, taken by mouth, for people with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or not responded to standard treatments. The study will first test AMX-883 alone, th…

This study tests whether injecting sodium thiosulfate directly into abnormal calcium deposits can shrink them and reduce pain. It includes people with three rare conditions: systemic sclerosis, dermatomyositis, and a genetic disorder called iPPSD2. Participants receive up to 11 i…

This study tests a new oral medication, upadacitinib, in children aged 1 to 17 with active systemic juvenile idiopathic arthritis (sJIA), a rare and serious form of arthritis that can affect the whole body. About 90 participants will receive either upadacitinib or the standard in…

This study tests whether using stem cells from both a half-matched family donor and a cord blood donor can improve survival without cancer returning. It is for people with certain high-risk blood cancers like leukemia or myelodysplastic syndromes. The approach aims to control the…

Researchers are comparing olverembatinib, an experimental drug, with bosutinib, an approved drug, in adults with chronic phase chronic myeloid leukemia (CML-CP). The trial enrolls patients whose disease has not responded well to at least two prior targeted treatments. A separate …

This early-phase trial is testing whether a long-acting antibiotic called dalbavancin, given once every 28 days along with a short course of oral antibiotics, can prevent serious bloodstream infections in children and young adults with high-risk leukemia. The study will enroll 29…

This early-stage study tests an oral drug called AUTX-703 in 34 adults with relapsed or hard-to-treat acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal is to check safety and find the right dose. It's an open-label trial, meaning everyone knows they'r…

This study tests two different drug combinations for younger adults with a specific type of acute myeloid leukemia (CBF-AML). One group gets standard chemotherapy plus a targeted antibody, while the other gets the same chemotherapy plus a newer targeted pill. The goal is to see w…

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain and skin plaques. Researchers will compare different doses of the drug to a placebo in 140 adults to see if it improves symptoms like joint tenderness an…

This study is testing a new drug called BGB-11417 (sonrotoclax) in people with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or related blood cancers. The drug works by blocking a protein that helps cancer cells survive. The trial will give the drug alone or toge…

This early-phase study tests whether adding the experimental drug ipatasertib to standard chemotherapy and radiation is safe and effective for people with advanced head and neck cancer. Ipatasertib may help stop cancer cell growth. About 46 participants will receive the combinati…

This early-phase trial tests whether giving patients a special infusion of donor immune cells (with certain T and B cells removed) after a stem cell transplant is safe and can help prevent their blood cancer from coming back. The study enrolls high-risk patients with hard-to-trea…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This phase II study is testing a combination of two drugs, enasidenib and azacitidine, in people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial enrolls 50 adults with a specific IDH2 gene mutation. The goal is to see if the combinati…

This study tests a new drug, INCA033989, against the best current treatments for people with a rare blood cancer called essential thrombocythemia who have a specific gene mutation (CALR). About 426 adults who have already tried at least one prior therapy will be randomly assigned…

Researchers are testing whether a balloon catheter coated with the drug sirolimus can safely open narrowed coronary arteries in adults with heart disease. The balloon inflates to press the drug into the artery wall, aiming to keep the vessel open without leaving a permanent stent…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This study tests a combination of three drugs—ivosidenib, venetoclax, and azacitidine—in people with blood cancers like acute myeloid leukemia (AML) that have a specific IDH1 mutation. The goal is to see if the combo is safe and works better than current treatments. About 96 adul…

This study compares two surgical approaches for hip dysplasia: the standard periacetabular osteotomy (PAO) alone versus PAO combined with hip arthroscopy. Researchers will enroll 106 people aged 15-55 with mild or no arthritis. The goal is to see if adding arthroscopy leads to be…

This early-phase trial is testing a new drug called Debio 1562M in about 134 people with acute myeloid leukemia (AML) that has come back or not responded to other treatments. The study first checks safety and finds the right dose, then looks at whether the drug can shrink the can…

This study tests a standardized, optimized approach to cord blood transplantation for adults with high-risk blood cancers like leukemia and lymphoma. The method includes specific chemotherapy, radiation, and stem cell dosing, followed by careful monitoring. Researchers hope to im…

This study is testing whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant, can prevent graft-versus-host disease (a common complication where donor cells attack the patient's body) while still being effective. The trial involves 260 adults with b…

This phase 2 trial tests a drug called olutasidenib combined with other targeted therapies for people with relapsed or hard-to-treat blood cancers that have a specific IDH1 mutation plus other signaling mutations. The study aims to see how safe and tolerable these drug combinatio…

This early-phase study tests a new drug called rezatapopt combined with the standard drug azacitidine in 24 adults with a specific type of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has a TP53Y220C mutation. The main goal is to check safety and find the b…

This study tests a gene therapy for GM1 gangliosidosis, a fatal disorder that destroys nerve cells. The therapy uses a harmless virus to deliver a working gene, helping the body produce a missing enzyme. Up to 54 children with Type I (ages 6-12 months) or Type II (ages 1-12 years…

This study tests a new drug called sonelokimab for adults with active psoriatic arthritis who have not improved with or cannot take standard TNF-blocker medications. About 600 participants will receive either sonelokimab, a placebo, or an existing drug (risankizumab) for comparis…

This study tests a daily pill called olutasidenib given after a stem cell transplant to people with certain blood cancers (like AML or MDS) that have an IDH1 mutation. The goal is to see if the drug is safe and tolerable as maintenance therapy. About 31 participants will take the…

This phase 2 trial tests whether adding the drug narlumosbart and precise radiation therapy to standard first-line treatment can help people with advanced non-small cell lung cancer that has spread to the bones. The study will enroll 27 adults who have not had prior systemic ther…

This study tests a combination of two drugs, venetoclax and azacitidine, in about 100 adults in India with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for standard intensive chemotherapy. The goal is to see if the combo can put the cancer into remissio…

Researchers are testing an experimental drug called LP-108, a BCL-2 inhibitor, combined with azacitidine in adults with acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. The trial aims to find the highest dose people can tolerate and the best …

This study tests a drug called olutasidenib in people with certain early blood conditions (CCUS, lower-risk MDS, or CMML) that have a specific IDH1 gene change. The goal is to see if the drug can control the disease and is safe. About 15 participants will take the drug and be mon…

This study tests a combination of three drugs—olutasidenib, decitabine, and venetoclax—in people with acute myeloid leukemia (AML) that has a specific IDH1 gene mutation. The goal is to find a safe and effective dose for those whose cancer has returned or not responded to treatme…

This study tests whether a lab-grown cartilage implant (MACI) works better than a standard surgery (microfracture) for teens aged 10-17 with knee cartilage damage. About 45 participants will receive either treatment and be followed for improvements in pain and sports function. Th…

This early-stage study tests a new drug called JNJ-88549968, a bispecific antibody designed to direct the body's immune T cells to attack cancer cells with a specific CALR mutation. The trial will enroll about 220 adults with essential thrombocythemia or myelofibrosis who carry t…

This study tests an experimental drug called BL-M11D1 combined with either standard chemotherapy or another targeted therapy in 216 adults newly diagnosed with acute myeloid leukemia (AML). The goal is to see if the combination is safe and works better at controlling the cancer. …

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to rec…

This Phase 3 trial tests whether adding the drug venetoclax to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) or a related high-risk condition. About 650 participants aged 18 to 75 will receive either venetoclax or a placebo alongside chemo. …

This study tests the long-term safety and effectiveness of an oral drug called zasocitinib (TAK-279) in adults with active psoriatic arthritis, a condition causing joint pain and skin patches. About 1,182 participants who completed a one-year parent study will take either a lower…

This early-stage study is testing an experimental drug called pivekimab sunirine in about 18 children whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to check the drug's safety and how it moves through the body. Partici…

This study tests a new treatment for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells…

This study tests a drug called Vyxeos in adults with acute myeloid leukemia (AML) whose cancer did not go away after standard chemotherapy. Vyxeos combines two chemo drugs inside a tiny fat bubble (liposome) to deliver them more effectively. The trial will check for side effects …

This study tests a new medicine called MAS825 for people with Still's disease, a rare inflammatory condition causing fever, rash, and joint pain. About 20 children and adults with active disease will receive the drug to see if it safely controls symptoms. The goal is to improve d…

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This study is testing a drug called secukinumab, given as an IV infusion, in 20 children aged 2 to 17 with juvenile psoriatic arthritis. The main goals are to see how the drug moves through the body and to check its safety over up to 6 years. This is an early-stage trial, so it f…

This Phase 3 trial tests whether the experimental drug zasocitinib (TAK-279) can reduce joint swelling and pain in people with active psoriatic arthritis. About 600 adults will receive either the drug or a placebo for up to 60 weeks. The main goal is to see if more people on the …

This early-stage trial tests a combination of two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose of momelotinib when given with gilteritini…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This early-stage trial is testing a new antibody drug called GEN3018 in people whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) has come back or stopped responding to treatment. The main goal is to check safety and find the right dose. Up to 78 parti…

This Phase III trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (doxorubicin) helps people with advanced dedifferentiated liposarcoma or undifferentiated pleomorphic sarcoma live longer without their cancer worsening. About 365 adults whose…

This early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected ar…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this comb…

This trial tests whether injecting a person's own bone marrow into a hip fracture site helps the bone heal faster and more completely. Adults aged 18 to 55 with a specific type of hip fracture will receive either standard screw fixation alone or screw fixation plus a bone marrow …

This phase 3 trial tests whether adding the drug sapablursen to standard treatment helps people with polycythemia vera, a blood disorder causing too many red blood cells. About 250 participants who currently need regular blood removal (phlebotomy) will receive either sapablursen …

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This study tests a combination of two drugs, trametinib and azacitidine, for children newly diagnosed with juvenile myelomonocytic leukemia (JMML), a rare blood cancer. Lower-risk patients get just these two drugs, while higher-risk patients also receive standard chemotherapy. Th…

This study tests a combination of three drugs—ASTX727, venetoclax, and gilteritinib—for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome that has a FLT3 mutation. The drugs work in different ways to stop cancer cells from growing. The trial aims to f…

This study tests a combination of two drugs, azacitidine and enasidenib, in people with a high-risk blood cancer called myelodysplastic syndrome (MDS) that has a specific genetic change (IDH2 mutation). The goal is to see if the drugs can stop cancer growth and improve outcomes. …

This early-stage trial tests a combination of two drugs—peposertib and a low-dose form of the chemotherapy doxorubicin—in people with advanced sarcomas that have spread or can't be removed by surgery. The goal is to find the safest dose and see if the combo can shrink tumors or s…

This study tests a new type of immune cell therapy for people with myeloid cancers (like AML or MDS) that have come back or not responded to treatment. The cells are taken from donated cord blood, engineered to better recognize and attack cancer cells, and given after chemotherap…

This early-phase trial is testing a combination of two oral drugs—venetoclax and decitabine/cedazuridine—in children and teens whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. The study aims to find the safest dose and check for early signs tha…

This phase 3 trial tests the drug radotinib in adults with chronic-phase chronic myeloid leukemia (CML) who have not responded to or could not tolerate earlier treatments such as imatinib. Participants take radotinib twice daily, and researchers measure how well it reduces leukem…

This phase 1 study is testing a combination of three drugs—ziftomenib, venetoclax, and azacitidine—in children and young adults (ages 2 to 21) with acute leukemia that has returned or not responded to treatment. The main goal is to find the safest dose of ziftomenib when given wi…

This study is watching how well asciminib works and how safe it is in adults with a type of blood cancer called chronic myeloid leukemia. It includes people who are newly diagnosed or have already tried one other treatment. The main goal is to see how many patients reach a very l…

This Phase 3 trial tests a gene therapy called FLT201 for adults with Gaucher disease type 1. The goal is to see if a single dose can keep blood counts stable so patients can stop their regular enzyme replacement or substrate reduction therapy. The study will enroll 45 people who…

This early-phase trial is testing whether a drug called camonsertib, combined with a precise type of radiation, can help control head and neck cancers that have come back or cannot be removed by surgery. About 39 adults with these cancers will receive the drug along with focused …

This study looks at whether giving the drug venetoclax for a shorter time, along with the combination drug ASTX727, works as well as the usual longer course for adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for strong chemot…

This early-stage trial tests an experimental pill called WJ01024 in people with myelofibrosis, a bone marrow disorder that often causes an enlarged spleen. The study has two parts: one gives WJ01024 alone to patients whose previous JAK inhibitor treatment stopped working, and the…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This early-stage trial tests whether adding special cells (DUOC-01) into the spinal fluid is safe for children with inherited metabolic diseases that damage the brain. Participants are ages 1 week to 21 years and are already receiving a standard umbilical cord blood transplant. T…

This trial tests whether people with rheumatoid arthritis who have stable disease can stop taking methotrexate or leflunomide while continuing their TNF inhibitor, restarting the drug if needed. Researchers compare this approach to staying on the combination therapy. They track d…

This study screens people with acute myeloid leukemia (AML) for specific genetic markers to assign them to a treatment sub-study with a targeted drug or combination. It aims to improve response rates by personalizing therapy based on each person's cancer profile. The trial enroll…

This early-phase trial is testing whether adding abemaciclib to the standard drug ruxolitinib is safe and effective for people with myelofibrosis, a type of bone marrow cancer. The study will enroll 18 adults who have been on ruxolitinib for at least 12 weeks. Researchers will mo…

This Phase 3 study tests whether the drug apremilast (Otezla) can safely reduce joint inflammation and pain in children aged 5 to 17 with active juvenile psoriatic arthritis. About 60 participants will receive either apremilast or a placebo pill for 16 weeks. The main goal is to …

This study tests a new drug called SLS009, alone or with other medicines, in people with blood cancers like leukemia and lymphoma that have come back or not responded to treatment. It also includes newly diagnosed patients with high-risk leukemia. The goal is to see if the drug i…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This pilot study tests the drug olutasidenib, with or without azacitidine, in 25 adults with a specific type of acute myeloid leukemia (IDH1-mutated) that has returned or not responded after venetoclax treatment. The goal is to see if the cancer can be brought into remission. Par…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy before a stem cell transplant can help prevent cancer from returning in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 participants aged 12 to 6…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This study looks at whether adding a bone marrow injection to standard knee surgery can improve pain and function for people with cartilage or meniscus injuries. Fifty adults aged 18 to 64 will be randomly assigned to get either the bone marrow injection or a placebo saltwater in…

This phase 3 trial is testing whether adding revumenib, a drug that blocks a protein called menin, to the usual two-drug combination (azacitidine and venetoclax) can improve outcomes for adults newly diagnosed with acute myeloid leukemia (AML) that has a specific genetic change (…

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participan…

This study tests two chemotherapy drugs, treosulfan and melphalan, given before a stem cell transplant in 220 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see which drug works better at helping patients survive longer with fewer side …

This study tests a drug called asciminib in children aged 1 to 18 with a specific leukemia (Ph+ CML-CP). The goal is to see if the drug can control the cancer by reducing the number of cancer cells. About 50 children will take the drug, and researchers will check how well it work…

This study tests whether taking two oral medications (decitabine and ivosidenib) together can control acute myeloid leukemia (AML) in patients aged 60+ or those too frail for standard chemo. About 50 participants will take the pills in 28-day cycles until the disease worsens or s…

This trial tests whether a smartphone app-guided rehabilitation program (MOKneeTOR) is as effective as traditional hospital-based physiotherapy for people with knee osteoarthritis. Participants will be randomly assigned to either use the app for 24 weeks or attend outpatient phys…

This trial tests whether the combination of venetoclax and azacytidine works better than the standard chemotherapy regimen of daunorubicin plus cytarabine in adults aged 18 to 64 with newly diagnosed acute myeloid leukemia that has adverse risk features. Participants are randomly…

This early-phase trial tests a new treatment called CD64 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to target and attack leukemia cells. The m…

This trial tests rusfertide, an injected drug, in Japanese adults with polycythemia vera, a rare blood cancer that causes too many red blood cells. The goal is to see if rusfertide can keep red blood cell levels under control and reduce the need for phlebotomy (blood removal). Al…

This study tests a new drug called TQH3906 for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 156 adults will receive either TQH3906, a placebo, or an existing drug (tofacitinib) for 12 weeks. The main goal is to see if TQH3906 impr…

This study tests whether adding the drug ruxolitinib to standard medications (cyclophosphamide and tacrolimus) can prevent severe graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers like leukemia. About 124 adults will receive the drug com…

This study tests a combination of a PD-1 inhibitor (camrelizumab), a chemotherapy drug (azacitidine), and donor immune cells (DLI) in 43 adults with acute myeloid leukemia that has returned after a stem cell transplant. The goal is to see if this approach can help patients achiev…

This study is testing a shoulder replacement device in 300 people with shoulder arthritis, bone death, or rotator cuff tears. Participants receive the implant and are followed for 10 years to see how well it works and if it is safe. The goal is to improve pain and shoulder functi…

This study tests a specially engineered donor graft called Orca-Q in children and young adults with blood cancers who need a stem cell transplant. The graft is designed to help the new cells take hold and reduce complications. The trial is currently on hold, but aims to enroll 40…

This early-phase trial is testing a new drug called miRisten in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to prior treatments. The drug works by blocking a molecule that helps cancer cells grow. The main goal is to check safety and find the best …

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This phase 3 trial tests whether adding the drug bleximenib to standard chemotherapy helps adults with a certain genetic type of acute myeloid leukemia (AML). About 875 people will get either bleximenib or a placebo alongside chemo, then be followed for 4 years. The goal is to se…

This study tests a surgical technique called the Bone Ring Technique (BRT) for placing dental implants in people with severe bone loss in the upper jaw. Normally, this requires two separate surgeries over many months, but BRT combines sinus lifting and implant placement into one …

This phase 2 trial compares a drug combo (ASTX727 plus iadademstat) against ASTX727 alone for people with advanced myeloproliferative neoplasms (MPNs), a group of rare blood cancers. The study aims to see if adding iadademstat improves complete response rates. However, the trial …

This study tests a drug called risankizumab in children with juvenile psoriatic arthritis, a condition causing joint pain and swelling. About 40 kids will receive either risankizumab or the standard drug adalimumab for 24 weeks, with responders continuing for up to 2 years. The g…

This phase 2 trial tests whether telitacicept, an experimental biologic given as a weekly injection, can improve symptoms in people with difficult-to-treat rheumatoid arthritis. Participants receive either telitacicept plus standard therapy or standard therapy alone for 24 weeks.…

This trial tests a procedure called trans-arterial embolization for people with chronic back pain caused by facet joint arthritis. Doctors inject tiny beads into the blood vessels feeding the painful joints to reduce blood flow and potentially ease pain. The study includes 40 adu…

This trial tests whether doing Schroth exercises at home works as well as doing them with a physiotherapist for teenagers with mild to moderate scoliosis. Participants aged 10-18 with a spinal curve between 10 and 45 degrees will be randomly assigned to either supervised or home-…

This early-stage trial tests a combination of two drugs, ivosidenib and ruxolitinib, in people with advanced blood cancers (MPNs) that have an IDH1 mutation. The main goal is to find the safest dose and see if the combo helps control the disease. About 18 adults will take part.

This study tests a daily oral drug called TYRA-300 in 92 children aged 3–10 with achondroplasia (a common form of dwarfism). The goal is to see if it safely increases their growth rate. Researchers will try different doses to find the best one. It's a Phase 2 trial, so it's still…

This trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can help people with sinonasal cancer, a rare cancer of the nasal cavity and sinuses. Participants receive toripalimab along with carboplatin and docetaxel, then undergo sur…

This trial tests two ways to correct flat head syndrome in infants: caregiver-led repositioning and a custom-fit helmet. Researchers will measure head shape changes in treated infants and compare them with a group of typically developing infants. Infants with torticollis will als…

This early-stage trial is testing whether adding high-dose vitamin C (given through an IV) to the usual two-drug combination (azacitidine and venetoclax) is safe and effective for people newly diagnosed with acute myeloid leukemia who cannot handle intensive chemotherapy. About 3…

This early-phase study tests a new drug called lonitoclax combined with azacitidine in 66 adults whose acute myeloid leukemia has returned or not responded to prior treatment. The main goal is to find a safe dose and check for early signs that the combination might help control t…

This trial tests whether a combination of venetoclax and azacitidine can work as well as or better than standard intensive chemotherapy for adults with newly diagnosed acute myeloid leukemia that has an NPM1 mutation. Participants are aged 18 to 70 and healthy enough for intensiv…

This trial compares a 3D-designed Boston brace with the standard Boston brace in 170 teens with idiopathic scoliosis, a spinal curve affecting about 3% of children. Participants wear the brace 20 hours a day until they reach skeletal maturity. Researchers measure whether the 3D b…

This study looks at how well a combination of two drugs—venetoclax (a pill) and azacitidine (an injection)—works for adults newly diagnosed with acute myeloid leukemia (AML), a cancer of the blood and bone marrow. The participants are people who are older or have health issues th…

This phase II trial is testing whether the drug ivosidenib, taken as a pill, can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic neoplasia (MDS) who have an IDH1 mutation and have recently undergone a stem cell transplant. Participants will sta…

This trial tests whether a single injection of a patient's own bone marrow concentrate (BMAC) can reduce knee pain and improve function better than the standard corticosteroid injection in people with knee osteoarthritis. Adults aged 18-70 with moderate knee arthritis and persist…

This study tests a 3-month virtual program called Choose to Move Replacement Ready for people on waitlists for hip or knee replacement due to osteoarthritis. The program offers choice-based physical activity and group support to help participants stay active, reduce pain, and imp…

This trial tests whether a new robotic system, KUNWU®, can accurately achieve the planned knee alignment during total knee replacement, regardless of which of two implant types is used. Adults with knee osteoarthritis needing surgery will be randomly assigned to receive either th…

This pilot study tests whether drinking tea made from soursop leaves can reduce the number of cancer cells in people with relapsed or refractory acute myeloid leukemia (AML) or multiple myeloma (MM) — blood cancers that have not responded to standard treatments. About 20 particip…

This trial tests whether adding metformin, a common diabetes medication, to a program of diet and exercise can reduce knee pain and improve function in overweight or obese adults with knee osteoarthritis. Participants will receive either metformin or a placebo for six months, alo…

This trial tests whether giving patients special immune cells, called TAA-T, after a stem cell transplant can help prevent high-risk blood cancers like acute myeloid leukemia from coming back. The cells are designed to recognize three common tumor markers and attack any remaining…

This trial tests whether transferring gut bacteria from a healthy donor (fecal microbiota transplantation, or FMT) can reduce disease activity in people with axial spondyloarthritis (axSpA) who haven't fully responded to biologic therapy. Participants receive a single enema with …

This trial tests whether a new type of hip resurfacing implant, called the H1, can be as successful as a standard total hip replacement for people with hip arthritis. Participants will receive either the H1 implant or a traditional replacement, and researchers will compare their …

This trial investigates different types of steroid injections for back, neck, and related pain to see which are most effective and safe. It compares various steroids, doses, and injection sites, including epidural and facet joint injections. The study measures pain relief and fun…

This phase 3 trial is testing whether an investigational drug called INT230-6, which combines three anti-cancer agents and is injected directly into tumors, can help people with advanced soft tissue sarcoma live longer than those receiving standard care. The study enrolls adults …

This study tests whether giving sarilumab (Kevzara) through an IV with longer intervals between doses is safe and works well for adults with moderate-to-severe rheumatoid arthritis. Participants receive the drug intravenously, with or without other standard arthritis medications.…

This trial is testing whether a chemotherapy combination called HAD, given at intermediate doses, works better than the standard regimen for people with a specific genetic subtype of acute myeloid leukemia (AML) known as CEBPA double-mutated. The study enrolls adults aged 14 to 5…

This trial asks whether people with rheumatoid arthritis who have low disease activity can safely reduce their JAK inhibitor dose without losing control of their symptoms. Participants will either follow a step-by-step dose-tapering plan or continue their usual full-dose medicati…

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This trial compares three common surgical procedures for thumb basal joint arthritis: trapeziectomy with ligament reconstruction, trapeziectomy with suture suspensionplasty, and arthroscopic trapeziectomy alone. The goal is to see which technique best restores grip and pinch stre…

This early-access program tests whether a weekly infusion of tralesinidase alfa directly into the brain's fluid spaces is safe and tolerable for children with Sanfilippo syndrome type B, a rare genetic disorder that causes severe neurological decline. The study enrolls about 10 c…

This trial tests whether a novel surgical technique called vertebropexy—which uses a donor ligament to stabilize the spine—can match or outperform standard decompression or fusion surgery for degenerative lumbar spinal disease. The study enrolls adults needing single- or two-leve…

This study looks at postmenopausal women with severe osteoporosis who have finished a course of either romosozumab or teriparatide. Researchers want to see which follow-up drug—zoledronate, denosumab, teriparatide, romosozumab, or abaloparatide—best maintains or improves bone den…

This trial tests whether adding an antibiotic-impregnated bone graft substitute (Cerament G) to standard surgery improves healing of heel bone infections (calcaneal osteomyelitis) in people with diabetes. Thirty participants will be randomly assigned to receive either partial rem…

This study tests different chemotherapy doses and a drug to prevent graft-versus-host disease in adults aged 18 to 60 with newly diagnosed acute myeloid leukemia. Participants receive either idarubicin or daunorubicin during initial chemo, followed by high or intermediate doses o…

This study compares two treatment strategies for people with active rheumatoid arthritis (RA) who have already tried a type of biologic called a TNF inhibitor. Participants are randomly assigned to switch to either a different class of biologic (non-TNFi) or a newer oral medicati…

This phase 3 trial tests whether a combination of two experimental drugs (futibatinib and zimberelimab) plus standard chemotherapy can help people with advanced biliary tract cancer live longer compared to current standard immunotherapy combinations. The study enrolls about 784 a…

This trial tests a special bone graft that releases the antibiotic tobramycin to treat infected knee replacements. The graft is placed during the first stage of revision surgery, with the goal of clearing the infection and promoting new bone growth. About 200 adults with infected…

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who rece…

This study tests a new implant called KeriFuse for fusing the last joint of fingers damaged by osteoarthritis. The implant is a staple made of a special metal that returns to its original shape after being placed, which may help the bone heal faster. About 50 adults with painful …

This trial tests a two-part treatment for people with acute myeloid leukemia (AML) that has not responded to standard therapy. First, patients receive a stem cell transplant from a healthy donor, but the stem cells are gene-edited to hide from the second treatment: specially engi…

This study tests whether adding pioglitazone (a diabetes drug) to standard tyrosine kinase inhibitors (TKIs) can help people with chronic myeloid leukemia (CML) who lost remission after stopping TKI therapy. Participants take the combination for at least six months, then stop all…

This study looks at whether giving the osteoporosis drug romosozumab in two separate 6-month blocks, with breaks for another drug called zoledronate, can build more bone than the standard 12-month course. It involves 270 postmenopausal women with osteoporosis and a recent fractur…

This study tests a new tool called OPTIBIO that uses blood markers and patient data to help doctors decide if it's safe to reduce biological therapy in rheumatoid arthritis patients who are in remission. About 184 adults with RA in stable remission will be randomly assigned to ha…

This study compares two types of partial knee replacements for people with arthritis on the inner side of the knee. One implant has a fixed bearing (the plastic piece stays still), while the other has a mobile bearing (the plastic piece can move slightly). Researchers will track …

This study tests whether taking a once-daily JAK inhibitor for rheumatoid arthritis in the evening works better than taking it in the morning. About 90 adults with RA who qualify for this medication will be randomly assigned to morning or evening dosing. Researchers will compare …

This study tests whether giving iron supplements to teens with iron deficiency before scoliosis surgery can reduce the need for blood transfusions and improve thinking and physical recovery afterward. About 275 participants aged 10-26 will receive either iron pills or a placebo f…

This phase II trial tests whether adding targeted total marrow irradiation to standard chemotherapy before a stem cell transplant can improve outcomes for people with high-risk acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndromes. The study will enroll 3…

This study is following over 5,200 people who have had or will have spine surgery using Stryker devices, such as spinal fusion or deformity correction. The goal is to see how well these devices improve pain and function, and to track any side effects or complications. Participant…

This study tests a new gene therapy for children with a severe inherited bone disease called osteopetrosis. The therapy uses the child's own blood stem cells, modified to fix the genetic defect, and then returned to the body. The goal is to improve blood cell production and survi…

This phase 2 trial tests whether a combination of pentoxifylline and vitamin E can help heal jaw bone damage caused by certain osteoporosis or cancer drugs. The study will enroll 17 adults with stage 2 medication-related osteonecrosis of the jaw. Researchers will measure how many…

This study tests a device called Vessel-X® that uses a special container to deliver bone cement into fractured vertebrae caused by osteoporosis. The goal is to reduce cement leakage and improve safety compared to standard procedures. About 146 adults aged 40 to 95 with spinal fra…

This early-phase trial is testing whether adding the drug daratumumab to standard chemotherapy can help adults aged 60 and older with a high-risk form of acute myeloid leukemia (AML). The main goal is to find the safest dose of daratumumab when given alongside chemotherapy. The s…

This early-stage trial tests a new treatment called ICG415 CAR-T cells for adults with acute myeloid leukemia that has come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, engineering them to recognize and attack leukemia cel…

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study tests whether a 20-day fasting schedule before hip replacement surgery can reduce complications like infections. 130 adults will either follow the fasting plan or receive standard care. Researchers will measure changes in gut bacteria and immune markers to see if fasti…

This study tests whether custom 3D-printed titanium implants can safely and effectively rebuild facial bones in 30 adults with defects from injury, cancer surgery, or birth conditions. Each implant is designed from CT scans to match the patient's unique anatomy. Researchers will …

This trial investigates whether montelukast, a common asthma medication, can reduce inflammation and prevent cartilage breakdown after anterior cruciate ligament (ACL) reconstruction. The study enrolls adults aged 25 to 50 who also have a meniscus tear, a group at high risk for r…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

Researchers at 32 medical centers in Europe, the USA, and South Africa are testing two new questionnaires designed to measure how severe chronic rhinosinusitis feels and how well it is controlled. About 1,000 patients with chronic rhinosinusitis, with or without nasal polyps, fil…

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

This Canadian study tests whether adding two questions about morning stiffness and lower back pain to a standard screening tool (PEST) can help dermatologists identify psoriatic arthritis earlier in people with moderate-to-severe plaque psoriasis. About 502 adults who are candida…

This study aims to improve how doctors diagnose Cushing's syndrome, a condition caused by too much cortisol. Researchers will test the accuracy of the desmopressin stimulation test in 140 people aged 18-70 who have or may have Cushing's, plus healthy volunteers. Participants will…

This study is developing an artificial intelligence platform to analyze knee ultrasound images and predict outcomes after ultrasound-guided injections for degenerative knee disorders like osteoarthritis. Researchers will first train the AI to identify normal and abnormal knee str…

This study tests a portable ultrasound system to measure the position of the shoulder blade (scapula) in patients with shoulder arthritis while they stand. The goal is to see if this non-radiation method can give results similar to CT scans taken when lying down. Thirty adults sc…

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

Researchers are testing whether washing the surgical site with antimicrobial solutions after the first cut lowers the amount of Cutibacterium acnes, a bacterium commonly found on the skin, during shoulder replacement surgery. Adults scheduled for a first shoulder replacement are …

This phase 3 trial tests whether xylitol dental wipes can reduce bloodstream infections in children with acute myeloid leukemia (AML). Xylitol, a natural sugar that limits mouth bacteria growth, is applied via wipes during chemotherapy. The study will compare infection rates betw…

This trial tests whether a 48-month program of dietary weight loss, exercise, and weight maintenance can prevent knee osteoarthritis in women aged 50 and older who have obesity and no or infrequent knee pain. Participants are randomly assigned to the diet-and-exercise program or …

This study tests whether a fecal microbiota transplant (FMT) can prevent graft-versus-host disease (GvHD) in 150 adults with blood cancers who receive a stem cell transplant. Patients get a single FMT enema within four weeks of transplant. The main goal is to see if FMT improves …

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This study tests whether a nasal spray called OPN-375 can reduce symptoms of chronic sinusitis (like stuffy nose, discharge, and facial pain) in adolescents aged 12 to 17. About 84 teens will receive either the spray or a placebo twice daily for 12 weeks. The main goal is to see …

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests a device that uses focused sound waves to block pain signals in the knee, offering a needle-free option for people with chronic osteoarthritis pain. Ten adults with moderate to severe knee pain will receive a one-hour treatment and be followed for six months. The…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

This study tests a new, ultrasound-guided acupotomy technique to improve symptoms in people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. About 60 adults with active disease will receive the treatment to see if it reduces pain and improves …

Avascular necrosis of the talus happens when the ankle bone loses its blood supply and collapses. Researchers are testing a custom-made implant shaped like the patient's own talus to replace the damaged bone. The study follows 50 adults for five years to see whether the implant r…

This study tests a 6-week physiotherapy program designed to improve pain, function, and joint awareness in adults with knee osteoarthritis. The program uses sensory modulation and graded weight-bearing exercises, and the trial compares outcomes between male and female participant…

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

Researchers are studying the Exactech Vantage Mobile-Bearing Total Ankle System, an implant used to replace a damaged ankle joint. The study enrolls 400 adults with ankle arthritis or related joint failure who are scheduled for total ankle replacement. Participants receive the im…

Researchers are studying the Exactech Vantage Total Ankle System, an implant used to replace a damaged ankle joint in people with arthritis or a failed previous replacement. The study enrolls 370 adults who are candidates for total ankle replacement and follows them for up to 10 …

Researchers are testing whether a nerve block called a PENG block reduces pain after periacetabular osteotomy, a major hip realignment surgery. In the study, 90 adults scheduled for this surgery receive either ropivacaine, a local anesthetic, or a saline placebo injected around s…

This study tests whether cannabidiol (CBD) can safely improve behavior, mood, sleep, and daily function in people with Sanfilippo syndrome, a rare genetic disorder. Thirty-five participants will receive either CBD or a placebo, then switch after a break. Caregivers will report on…

This study tests a program called EASE that combines psychological support with regular symptom checks and early access to palliative care. Researchers want to see if it reduces traumatic stress and physical symptoms in people newly diagnosed with acute leukemia. Half of the 266 …

This study tests whether a modified version of the muscle relaxant metaxalone (640 mg) can reduce low back and leg pain in people with acute sciatica or spinal stenosis. Fifty adults aged 18 to 80 with new-onset pain will take either the drug or a placebo for 7 days. Researchers …

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

Researchers are testing two physical therapy approaches for adults aged 40 to 60 with chronic neck pain and confirmed cervical spondylosis. Both groups do deep neck flexor training guided by a pressure biofeedback device, and one group also adds shoulder-blade stabilization exerc…

Researchers are testing whether giving the steroid dexamethasone during total knee replacement helps with pain, nausea, and recovery, and whether it matters if the drug goes into a vein or is injected around the knee joint. The trial enrolls 159 adults with knee osteoarthritis ha…

This study tests a home-based exercise program called CAREFit-BMT for people with high-risk acute myeloid leukemia who are about to have a stem cell transplant. The program includes aerobic and strength training to improve heart function before the procedure. Researchers will enr…

This study tests three different numbing medicine combinations for pain after total knee replacement. 90 adults having knee surgery will get one of three options: a long-acting numbing drug, or a standard numbing drug plus one of two additives. The goal is to see which approach r…

Researchers are testing whether adding gait re-education on an R-Force anti-gravity treadmill to standard physiotherapy helps adults with knee osteoarthritis. The trial enrolls 80 people aged 40 to 70 who have radiologically confirmed knee arthritis and ongoing knee pain. Partici…

Researchers are studying whether skipping opioids during functional endoscopic sinus surgery leads to better recovery. The trial follows 104 adults with chronic sinusitis who receive anesthesia with dexmedetomidine and other non-opioid pain relievers instead of standard opioid dr…

This study compares two surgical treatments for rhizarthrosis, a type of arthritis at the base of the thumb. One group gets a new prosthesis (HORUS implant), the other gets the standard trapezectomy. Researchers will measure hand function and pain in 50 patients over the short te…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This trial tests whether botulinum toxin type A injections can improve lower-lip asymmetry in children with hemifacial microsomia, a condition where the lower lip moves unevenly during smiling or speaking. The study enrolls children under 18 with this condition and a crooked-mout…

This study tests whether a newer multi-tined electrode provides longer pain relief than a standard single-tip electrode during radiofrequency ablation for lumbar spondylosis, a common cause of lower back pain. About 25 adults with chronic lower back pain from worn facet joints wi…

Researchers at the University of Alberta are comparing two virtual physical therapy programs with usual care for rural adults who have hip or knee osteoarthritis and are not waiting for joint replacement surgery. Participants first continue their usual arthritis care for 12 weeks…

Researchers are testing whether an augmented reality guidance system helps surgeons make more accurate bone cuts and align knee implants during total knee replacement. The study enrolls about 50 adults with advanced osteoarthritis who are scheduled for a primary knee replacement …

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

This study tests whether giving a numbing medicine (bupivacaine) as a mist before surgery can lower pain and the need for extra painkillers in children aged 1-7 having cleft palate repair. Half the children get the mist, half get a placebo, and neither the doctors nor families kn…

This study will follow 86 adults with knee osteoarthritis to see if injections of sugar-water (dextrose) or local anesthetic around the knee nerves provide better pain relief and function. Participants will be assessed for six months after their routine injection. The goal is to …

This study tests whether giving a steroid (dexamethasone) during shoulder replacement surgery can improve recovery. Researchers will measure pain, nausea, shoulder movement, and how long patients stay in the hospital. The study involves 74 adults with shoulder arthritis who are h…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This trial compares two injection sites for steroid shots in people with moderate-to-severe knee osteoarthritis. Participants get the injection on either the inside or outside of the knee, then report pain and function over 12 weeks. The goal is to see if one spot provides better…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This trial tests whether remote tai chi, taught through web-based sessions twice a week for 12 weeks, can reduce knee pain in adults aged 50 and older with knee osteoarthritis. Researchers compare adding remote tai chi to routine care against routine care alone, measuring pain, p…

This trial tests two digital platforms, one for children with cancer and one for their parents, designed to improve communication with healthcare providers and address physical, emotional, social, and spiritual needs during treatment. Researchers will recruit 120 families of chil…

This phase 2 trial is testing whether daily doses of THC, CBD, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 participants will take one of the study drugs or a placebo for 16 weeks, with regular pain assessments, blood tests, and brain…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This trial tests two common injections for pain in the shoulder, elbow, wrist, or hand caused by arthritis or tendon problems. One injection is triamcinolone, a corticosteroid that reduces inflammation. The other is ketorolac, a non-steroidal anti-inflammatory drug (NSAID). Parti…

This study tests whether hyaluronic acid injections into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also measure changes in inflammation-related substances in blood and joint fluid. 50 adults aged 45-75 with moderate knee os…

This trial tests whether adding Pain Neuroscience Education to standard pre-operative physiotherapy helps adults aged 35 to 60 recover better after lumbar spine surgery. Participants scheduled for a laminectomy receive either standard exercises alone or the same exercises plus th…

This study tests two different nerve block methods to control pain in people with multiple broken ribs. The goal is to see which technique provides better pain relief, helps patients breathe deeper, and shortens hospital stays. Thirty-six adults with at least two rib fractures wi…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study follows 270 adults having knee replacement surgery to see if the steroid dexamethasone (given as a pill or through a vein) helps with early recovery. Researchers will measure pain, mobility, nausea, and need for extra painkillers. The study does not assign treatments—p…

This trial tests whether using two probes during radiofrequency ablation eases knee osteoarthritis pain better than the standard one-probe approach. Radiofrequency ablation uses heat to quiet the nerves that send pain signals from the knee. Researchers will enroll 64 adults over …

This pilot study will test whether a non-invasive vagus nerve stimulation (nVNS) device can reduce jaw pain and improve mood in 10 premenopausal women with temporomandibular disorders (TMD). Participants will receive the treatment twice a week for 8 weeks and undergo brain scans,…

This phase 3 trial tests whether ecnoglutide, a GLP-1 drug similar to semaglutide, can reduce knee pain and body weight in obese adults with knee osteoarthritis. Participants receive either ecnoglutide injections or a placebo for several months. The study measures changes in pain…

This study tests whether a personalized exercise program can improve physical function and quality of life in adolescents and young adults who have survived sarcoma. Participants first complete a triage tool to assess their needs, then receive a 12-week exercise plan that may inc…

This trial tests whether a personalized mobile app can improve recovery after reverse shoulder replacement surgery. About 170 adults undergoing this procedure will be randomly assigned to either use the interactive app or receive standard care. The main goal is to see if the app …

This pilot study tests whether giving teenagers a carbohydrate drink before scoliosis surgery helps them recover faster and feel better. Participants will be randomly assigned to either receive the drink or follow standard fasting rules. The study looks at whether the drink impro…

This study tests whether a tailored physical activity program can help older adults maintain thinking and memory after a stem cell transplant for blood cancers. Participants aged 60 and older will follow a progressive, light-to-moderate exercise plan with support from therapists …

This study investigates whether a low-carbohydrate diet can reduce pain and improve quality of life in adults with knee osteoarthritis, compared to a standard USDA-recommended diet. Participants will follow a 6-week diet plan with all meals provided, and researchers will measure …

This trial tests a program called ACT, which trains doctors and nurses to have compassionate, structured conversations with blood cancer patients and their families about end-of-life care. The goal is to help patients understand their prognosis and make informed decisions, potent…

This study tests whether improving sleep before total knee replacement surgery can reduce pain after the operation. Adults aged 60 and older with knee osteoarthritis and sleep difficulties will receive either cognitive-behavioral therapy for insomnia, bright light therapy, or a c…

This trial tests whether eccentric strengthening exercises or low-load blood flow restriction training can improve muscle function, strength, and daily mobility in people with knee osteoarthritis. Participants aged 40 to 70 with mild to moderate knee arthritis will follow a four-…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This trial tests whether a combination of electrotherapy (low-level laser and interferential current) or shock wave therapy, alongside stretching and strengthening exercises, can reduce pain and improve grip strength in menopausal women with tennis elbow. The study includes 45 wo…

This trial investigates whether Reiki, a gentle hands-on energy therapy, can help reduce pain and improve recovery in people undergoing lumbar spine surgery. Sixty participants will be randomly assigned to receive either two sessions of real Reiki or a sham (placebo) treatment al…

This trial compares two types of nerve blocks for pain control after bilateral total knee replacement. One combines a standard numbing medication with two steroids, the other uses a long-acting liposomal bupivacaine. Researchers want to see if the steroid-enhanced block provides …

This phase 2 trial tests whether a nerve block containing bupivacaine plus two steroids (dexamethasone and methylprednisolone) can provide better pain relief after total knee replacement than the standard combination of bupivacaine and liposomal bupivacaine (Exparel). About 250 a…

This study tests whether a 30-minute virtual reality session with nature scenes and music can reduce pain, anxiety, and improve comfort in people who just had hip replacement surgery. Participants choose from forest, beach, underwater, or outdoor footage. The goal is to see if VR…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether an enhanced recovery after surgery (ERAS) protocol helps people recover faster after total knee replacement. About 120 patients aged 50-70 will either get standard care or the ERAS plan, which includes pre-surgery exercise, shorter fasting, and early walk…

This trial compares two injection treatments for knee osteoarthritis: a combination of platelet-rich plasma (PRP) and hyaluronic acid versus hyaluronic acid alone. Researchers want to see if the combined approach provides better pain relief and function after one year. The study …

Lateral epicondylitis, often called tennis elbow, causes pain and tenderness on the outside of the elbow and can linger despite treatment. Researchers are comparing 128 people with chronic lateral epicondylitis to healthy controls to see whether those with elbow pain have lower p…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study looks at how much of the drug bimekizumab passes into breast milk. Researchers will collect milk samples from 20 breastfeeding mothers with conditions like psoriasis or arthritis over several weeks. The goal is to understand potential exposure for nursing infants, not …

This study tests a new way to screen patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) by analyzing their bone marrow and blood for specific biomarkers. The goal is to quickly match patients with a treatment trial that targets their cancer's unique mark…

Researchers are studying whether blood levels of luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are linked to the presence, severity, and long-term outcomes of endocrine disorders such as osteoporosis, thyroid disease, and adrenal gland problems. The study enroll…

This study tracks the natural course of fucosidosis, a rare genetic disorder, in up to 57 people. It collects medical history and ongoing health data without giving any experimental treatment. The goal is to better understand the disease and help design future therapies.

This study looks at whether adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy are willing to let a computer randomly assign them to either lower- or higher-intensity treatment. The goal is to see if this approach is acceptable to patients…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study looks at thumb osteoarthritis, a common cause of pain and weakness at the base of the thumb. Researchers will assess 93 people using a broad approach that includes physical, psychological, and social factors. They will also test whether artificial intelligence can pred…

This study is for people with certain autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn more about what causes these diseases and how they affect the body over time. Participants will have medical tests a…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study follows adults with melorheostosis, a rare disease that causes bone thickening, pain, and joint problems. Researchers will track how the disease progresses over time, collect genetic samples from patients and their relatives, and look for biomarkers. The goal is to bet…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study looks at the long-term health of people who were cured of Cushing disease before age 21. Researchers want to understand how past high cortisol levels affect the body and mind years later. Participants will complete surveys and have check-ups every 5 years. The goal is …

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study explores whether inflammation from fat tissue around the spine contributes to spinal stenosis, a condition that narrows the spinal canal and causes pain. Researchers will collect tissue and blood samples from 100 patients undergoing spinal surgery to measure levels of …

This natural history study follows up to 4,000 people with inherited bone marrow failure syndromes (IBMFS) and their families to learn why they are prone to certain cancers. Researchers will track health over time, collect genetic samples, and look for clues that separate those w…

This study follows people with rare genetic disorders that cause harmful substances to build up in the body, leading to brain damage. Researchers will monitor up to 200 participants over time using exams, surveys, and lab tests. The goal is to better understand how these diseases…

This study follows up to 500 people with polyostotic fibrous dysplasia or McCune-Albright syndrome to learn how these conditions change over time. Researchers will collect medical data and tissue samples to better understand the disease. The goal is to improve future diagnosis an…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 patients through biopsy or surgery to assess quali…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This study looks back at medical records of adults with myelofibrosis who took pacritinib for at least a month. Researchers will track changes in spleen size, blood counts, symptoms, and survival to see how the drug performs in everyday practice. The goal is to understand real-wo…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

Trigonocephaly is a condition where a baby's skull fuses too early along the forehead, giving the head a pointed shape. Doctors often operate to relieve pressure on the growing brain, but some children may do just as well without surgery. This study follows children aged 0 to 8 w…

This study tests a telehealth program that helps older adults (60+) with blood cancers like leukemia or MDS talk to their doctors about their care wishes. The program also helps them fill out advance directive forms. Researchers want to see if it improves communication and reduce…

This study follows people of all ages who have or may have a RUNX1 gene variant, which can cause bleeding problems and increase the risk of blood cancers. Researchers will collect medical history, blood samples, and bone marrow over many years to understand how the condition deve…

This study looks at the financial stress that patients with bone or soft tissue sarcoma face after surgery. Researchers will ask 100 adults to fill out questionnaires about the costs of their cancer care and how that affects their quality of life. No new treatments are being test…

This pilot trial tests whether a single-use flexible bronchoscope can safely and effectively replace the semi-rigid pleuroscope for diagnosing pleural effusion—a buildup of fluid around the lungs. Hospitalized patients needing a tissue sample will be randomly assigned to one of t…

Researchers are building a registry to collect long-term health information from adults with myelodysplastic syndromes and therapy-related acute myeloid leukemia. The study gathers details on blood counts, bone marrow tests, genetic changes, and treatments. By following these pat…

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before an…

This study aims to understand the genetic and biological causes of Proteus syndrome, a rare condition causing abnormal growth of bones, skin, and other tissues. Researchers will follow up to 1,500 participants over time, using medical exams, imaging, and blood tests to track how …

This study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition causing fevers and organ damage. Researchers will follow 300 participants for up to 3 years, collecting blood samples and medical data to identify…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in brea…

This study looks at 60 adults with acute myeloid leukemia or related blood cancers who are receiving a gentler type of chemotherapy. Researchers will measure certain proteins in the blood to see if they can predict how well the treatment works. The goal is to better understand wh…

This study tests whether digital education or in-person classes help people over 50 with osteoporosis take better care of themselves. Six hundred participants will be split into three groups: one gets standard information, another attends three group sessions with a physiotherapi…

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…

This study looks at whether a protein called BDNF in the blood matches the degree of spinal disc wear seen on MRI and levels of an inflammation marker called IL-1β. Researchers will measure BDNF in blood samples from 59 people with low back or leg pain caused by disc degeneration…

This study will follow 8,000 Medicare patients with lumbar spinal stenosis who receive either the MILD procedure or interspinous process decompression. Researchers will track complications and whether patients need additional surgery within two years. The goal is to see which app…

Researchers in Italy are building a large registry of adults newly diagnosed with myelodysplastic syndromes, a group of blood cancers where the bone marrow does not make enough healthy blood cells. The study will collect data on up to 10,000 people to measure how many new cases o…

This study collects and stores medical information from people treated for orthopaedic conditions like osteoarthritis, scoliosis, and cerebral palsy. Researchers at the University of Florida will gather data during routine clinical care to create a resource for future research. T…

Researchers at University Hospital Bonn are following 300 adults who undergo knee or hip replacement surgery to understand how their recovery unfolds. The study measures quality of life, hand grip strength, and bone density before and after the procedure. The goal is to identify …

This study is collecting blood, bone marrow, and leftover tissue samples from 550 people with acute myeloid leukemia or follicular lymphoma. Researchers will analyze the samples to find genetic markers that may predict how well treatments work or why some stop working. The goal i…

This observational study looks at whether oral health and the bacteria in saliva are linked to disease activity in children with juvenile idiopathic arthritis (JIA). Researchers will compare children with active disease to those in remission, examining their teeth, gums, oral hyg…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study aims to learn more about alkaptonuria, a rare genetic disease that causes a pigment to build up in bones and tissues, leading to arthritis and other problems. Researchers will evaluate 300 patients over several years using advanced medical tests. The goal is to better …

This study looks at whether malnutrition changes how well older adults recover after shoulder surgery when they use virtual reality (VR) for rehabilitation. Researchers will track 60 frail adults aged 60+ to see if poor nutrition limits the benefits of VR therapy. The goal is to …

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study tests a small MRI coil placed inside the sphenoid sinus during pituitary tumor surgery. The goal is to see if it can provide clearer images of tiny tumors that standard MRI often misses. About 70 adults with pituitary tumors will take part. The coil is inserted through…

This study follows up to 1,000 people with osteogenesis imperfecta, also known as brittle bone disease, a rare condition that causes bones to break easily. Researchers aim to connect each person's genetic cause with their symptoms, disease progression, and response to current tre…

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This study looks at 40 adults with psoriasis—some with joint pain (psoriatic arthritis) and some without—to compare immune signals in their blood and skin. Researchers want to understand why some people develop joint problems. Participants give blood and skin samples for lab anal…

Researchers are following up with about 50 patients who received the IntraSPINE implant for lower back pain caused by degenerative disc disease. The goal is to see whether the implant still provides meaningful improvement in function and pain at least 9 years after surgery. They …

This study looks at how the antibiotic rifampicin is processed by the body in people with staphylococcal bone and joint infections, such as prosthetic joint infections and chronic osteomyelitis. Researchers will take blood samples from 40 participants to measure drug levels and b…

This observational study looks at how physical activity, sedentary time, and sleep relate to early signs of heart and blood vessel disease in adults with rheumatoid arthritis. Participants will wear activity monitors for a week, answer health questionnaires, and undergo heart and…

This study follows 160 people with inflammatory joint disease who are starting treatment with or without glucocorticoids, or receiving a glucocorticoid injection. Researchers will measure bone turnover markers (P1NP and CTX1) in blood samples every 4 weeks and up to 6 months afte…

This observational study aims to understand why some people with rheumatoid arthritis (RA) continue to experience chronic pain even when their inflammation is well-controlled. Researchers will compare two groups of RA patients—those with active disease and those in remission with…

This study looks at whether ultrasound measurements of thigh muscle and fat can predict how well patients with knee osteoarthritis respond to a genicular nerve block. Researchers will measure muscle thickness and fat under the skin before the procedure and check pain levels one m…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This study looks at whether certain markers of oxidative stress in the blood are linked to early signs of heart disease in people with rheumatoid arthritis. Researchers will measure these markers and check for thickening or stiffness in the carotid arteries. The goal is to better…

This study investigates whether a blood marker called anti-Müllerian hormone (AMH) can predict future infertility in children and adolescents who have undergone cancer treatment. Many young patients recover normal menstrual cycles or puberty after chemotherapy, but their ovarian …

This study enrolls people diagnosed with cancer to build a large registry using Olivia, an AI-powered health platform. The platform will collect and combine electronic health records and patient-reported outcomes from over 1,000 healthcare systems. The goal is to create a compreh…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study looks at whether tyrosine kinase inhibitors (TKIs), the standard treatment for chronic myeloid leukemia (CML), might be linked to erectile dysfunction (ED) in men. Researchers will track 350 male patients who started TKI therapy, using questionnaires and medical record…

This study looks at whether measuring the amount of venetoclax in the blood can help doctors give the right dose to people with newly diagnosed acute myeloid leukemia (AML). Currently, everyone gets the same dose, but drug levels vary a lot between patients. The goal is to find a…

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This study looks at whether screening adults with leukemia for social needs (like housing or food) and offering early social work help is practical and helpful. About 80 newly diagnosed patients will either get the screening and consultation or usual care. The goal is to see if t…

This study follows adults with a suspected bone or soft tissue tumor to see how their stress and anxiety levels change at three critical moments: before biopsy, after learning the diagnosis, and when treatment begins. Participants fill out standard questionnaires about anxiety, d…

This study uses a special MRI technique to measure energy molecules (ATP and phosphate) in the leg muscles of people with phosphate diabetes, a condition that causes bone pain and muscle fatigue. By comparing measurements at rest and during exercise, researchers hope to uncover t…

This study compares the prevalence of the HLA B leader gene in 658 people with psoriatic arthritis and a healthy control group. Researchers will also look at the related HLA B27 gene. The goal is to see whether this genetic marker, already known to affect outcomes in bone marrow …

This study will collect and analyze nasal tissue from 230 Greek patients with chronic sinusitis (with or without nasal polyps) to identify different inflammation patterns, called endotypes. By understanding these patterns, researchers hope to better match patients with the most e…

This registry will follow 1,000 adults with chronic-phase CML who are taking approved TKIs (like Gleevec or Tasigna) as their first or second treatment. Over 5 years, researchers will track side effects, treatment changes, and patient-reported experiences to understand how these …

This study investigates knee osteoarthritis and cartilage degeneration by combining MRI scans with gait analysis. Researchers aim to better understand how the disease affects both the structure and function of the knee joint. The study involves 25 participants with knee pain or c…

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study looks at a new tool called the Functional Muscle-Bone Incongruity Index (FKUI) that combines handgrip strength and bone density measurements. Researchers want to see if this combined approach gives a fuller picture of muscle and bone health than looking at each measure…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study gathers blood and bone marrow samples from 150 adults with myelodysplastic syndrome (MDS), a blood disorder that can turn into acute leukemia. Researchers want to find biological markers that help predict which patients are likely to progress to leukemia. The goal is t…

This study is testing a new device called BloodTrackR that lets people with rheumatoid arthritis collect a small blood sample at home using a finger prick and a smartphone app. Twenty participants will try the device and answer questions about how easy it is to use. The goal is t…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study looks at how people who have lost an arm or were born without one experience phantom limb sensations—like feeling their missing hand move. Researchers will interview participants and map these sensations to help design prosthetics that are easier to control and feel mo…

This study looks for proteins and other factors that might predict whether a teenager's scoliosis curve will get worse. Researchers will compare blood samples and health information from 500 teens with and without scoliosis over 6–12 months. The goal is to better understand what …

This observational study examines a specific group of patients with a type of acute myeloid leukemia (AML) that has an NPM1 mutation. Researchers want to see if a particular subset, called APL-like, is linked to early blood vessel problems like bleeding or clots. The study will l…

This study follows people with a rare and advanced cancer of the nasal cavity and sinuses called T4 sinonasal adenoid cystic carcinoma. All participants receive the standard treatment: surgery followed by radiation therapy. The goal is to measure how long people live without the …

This study looks at whether a simple, non-invasive fingertip sensor (called pleth variability index, or PVI) can help doctors track blood pressure and fluid needs during skull surgery in children aged 0 to 6 years with craniosynostosis. The researchers will compare PVI readings w…

This study investigates why some children still have speech problems (velopharyngeal insufficiency) after cleft palate surgery. Researchers will use real-time MRI to look at how the soft palate moves and its muscle structure in children aged 7 to 12. By comparing children with di…

This study uses leftover tissue from heart and orthopedic surgeries to learn more about how calcification (hardening) happens in bones and blood vessels. Researchers will grow cells from these tissues in the lab to study the process. The goal is to better understand the disease, …

This study is creating a central database and tissue bank for rare diseases affecting the kidneys and liver, such as ARPKD and Joubert syndrome. Researchers will collect medical information, genetic samples, and tissues from 200 participants to help doctors and scientists better …

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study is testing whether a blood test that looks at tiny genetic molecules called microRNAs can accurately detect bone problems in people with chronic kidney disease. Currently, doctors rely on a bone biopsy, which is invasive and not practical for most patients. The researc…

This study collects blood and bone marrow samples from 80 adults newly diagnosed with acute myeloid leukemia (AML). Researchers will measure inflammasome activity before and after standard chemotherapy to see if it relates to how well the treatment works. The goal is to better un…

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study compares two ways of tracking recovery after knee replacement surgery: traditional paper questionnaires filled out at the clinic versus digital surveys sent to a patient's smartphone. Researchers will enroll 50 adults aged 18-78 who own a smartphone, tablet, or compute…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …