Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can specialized exercise ease knee arthritis disability?

NCT ID NCT07733518

Symptom relief Sponsor: Riphah International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This trial tests whether eccentric strengthening exercises or low-load blood flow restriction training can improve muscle function, strength, and daily mobility in people with knee osteoarthritis. Participants aged 40 to 70 with mild to moderate knee arthritis will follow a four-week supervised exercise program. The study measures changes in muscle activity, pain, stiffness, and physical function to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
eccentric gastrocnemius strengthening exercises and low-load blood flow restriction training
What this could lead to
If effective, this could offer a non-drug exercise option to improve muscle strength and reduce disability in knee osteoarthritis.
What could go wrong
This is a small, early-stage trial with only 48 participants, so results may not apply broadly. The exercises may be difficult for some people with knee pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age group 40-70 * Both genders male and female * Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee. * Pain stable enough to permit exercise on Numeric Pain Rating Scale 3/10. * Participants must demonstrate a gastrocnemius muscle strength of grade ≥3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position. * Participants must be able to ambulate independently and participate in supervised exercise. Exclusion Criteria: * • Presence of a prosthetic knee in the affected limb. * Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA. * Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension ≥160/100 mmHg). * Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation). * History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding/clotting disorders. * Current anticoagulant therapy that increases bleeding risk (unless cleared by physician). * Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Knee arthritis osteoarthritis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Muscle Weakness osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthritis osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Railway General Hospital, Rawalpindi

    RECRUITING

    Rawalpindi, Punjab Province, 46000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.