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Can sound waves soothe aching knees?

NCT ID NCT07738692

Symptom relief Sponsor: Horus University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether different types of ultrasound therapy can ease pain and stiffness in people with knee osteoarthritis. Adults aged 45 to 65 with mild-to-moderate knee arthritis will receive ultrasound treatment, sometimes with a metformin gel applied to the skin. The study measures changes in pain, joint function, and range of motion to see if this approach offers relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultrasound therapy (with or without metformin gel as a coupling medium)
What this could lead to
If effective, this could offer a non-invasive way to reduce knee pain and improve mobility in people with osteoarthritis.
What could go wrong
The trial is small and early, so results may not apply broadly. Ultrasound therapy may provide only temporary relief, and the addition of metformin gel is experimental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jan 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 45 to 65 years. * Body mass index (BMI) 18.5-29.9 kg/m². * Diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria. * Kellgren-Lawrence grade I-III. Exclusion Criteria: * Rheumatologic conditions such as rheumatoid arthritis. * Prior knee surgery. * Previous lower-extremity fracture involving the knee joint. * Diabetes mellitus. * Neuropathy or sensory disorders. * Intra-articular corticosteroid injection or platelet-rich plasma treatment within the previous 6 months. * Thrombosis of the lower limbs. * Contraindications to therapeutic ultrasound, including open epiphysis, infection, cardiac disease, metal implants, pacemaker, pregnancy, or thrombophlebitis. * Wound or laceration in the soft tissues surrounding the knee. * Skin disease around the treatment area. * Use of pain medications during the study that could influence outcomes. * Knee physiotherapy within the previous 3 months. * Other knee procedures, including aspiration or knee arthroplasty.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthritis osteoarthritis

Contacts and locations

Locations

  • Horus University

    Quweisna, Monufia Governorate, 16916, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.