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Scientists hunt for biomarkers to predict spinal stenosis progression

NCT ID NCT07232836

Knowledge-focused Sponsor: Poznan University of Physical Education Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 17, 2026 · Updated 3 times

Summary

This study explores whether inflammation from fat tissue around the spine contributes to spinal stenosis, a condition that narrows the spinal canal and causes pain. Researchers will collect tissue and blood samples from 100 patients undergoing spinal surgery to measure levels of various inflammatory molecules. The goal is to identify biomarkers that could help monitor disease and guide future non-surgical treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify biomarkers to monitor spinal stenosis and point to new non-surgical treatments targeting inflammation.
What could go wrong
This is an early observational study, not a treatment trial. It may not lead to any new therapies, and the findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for the experimental group: 1. Spinal stenosis in the lumbar spine with a referral for surgical treatment using endoscopic spinal decompression. 2. Age: 40-90 years. 3. Current MRI results. 4. Consent to participate in the study. Inclusion Criteria for the control no spinal stenosis group: 1. Intervertebral disc herniation in the lumbar spine with a referral for surgical treatment using endoscopic discectomy. 2. Age: 18-40 years. 3. Current MRI results. 4. Consent to participate in the study. Exclusion Criteria: History of: * rheumatoid arthritis of the intervertebral joints, * joint pain located elsewhere if it is more severe than the pain caused by stenosis, * pathologies and/or medications that may disturb the balance between pro- and anti-inflammatory factors (e.g. inflammatory diseases, rheumatoid arthritis, ankylosing spondylitis, acute infection), * uncontrolled diabetes, poorly controlled hypertension, clinically significant liver function impairment, acute coronary event, unstable angina pectoris, symptoms of heart failure, pacemaker implantation, * neurological diseases within the last 6 months, * previous spine surgery at the lumbar level, * mechanical injuries to the spine after an accident, * advanced osteoporosis, * pregnancy, lactation.

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Conditions

The condition(s) this trial relates to.

Inflammation lumbar spinal stenosis spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ligamentum flavum hypertrophy Spinal stenosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi w Poznaniu

    RECRUITING

    Poznan, Wielkopolska, 61-545, Poland

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