New combo aims to tame aggressive blood cancers in 62-Patient trial
NCT ID NCT06661915
First seen Oct 31, 2025 · Last updated Jun 14, 2026 · Updated 33 times
Summary
This study tests whether adding iadademstat to the drug ASTX727 works better than ASTX727 alone for people with advanced myeloproliferative neoplasms (MPNs), a group of blood cancers. About 62 adults whose cancer has progressed to a more aggressive phase will be randomly assigned to one of the two treatments. The goal is to see if the combination can improve the rate of complete leukemia response, but this is not a cure—patients may need ongoing therapy.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025, United States
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Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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NYP/Weill Cornell Medical Center
New York, New York, 10065, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304, United States
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UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612, United States
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UChicago Medicine Northwest Indiana
Crown Point, Indiana, 46307, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, Florida, 33065, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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UM Sylvester Comprehensive Cancer Center at Doral
Doral, Florida, 33166, United States
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UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, Florida, 33021, United States
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UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, 33176, United States
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UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, 33324, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, 66211, United States
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University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, Florida, 33181, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.