Disorder of facial skeleton

This early-phase study tests whether adding the experimental drug ipatasertib to standard chemotherapy and radiation is safe and effective for people with advanced head and neck cancer. Ipatasertib may help stop cancer cell growth. About 46 participants will receive the combinati…

This study tests whether a less invasive surgery called sentinel lymph node biopsy can replace standard neck dissection for early-stage oral cavity cancer. About 686 patients will be randomly assigned to one of the two procedures. The goal is to see if the gentler approach mainta…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This trial compares standard cleft palate surgery alone versus surgery augmented with platelet-rich fibrin (PRF) or gentamicin-loaded PRF in 90 children and adolescents with cleft palates. The goal is to see if these biological adjuncts improve wound healing, reduce wound breakdo…

This study tests whether a handheld device that strengthens the muscles used for breathing and swallowing can improve speech in children aged 5 to 17 with velopharyngeal dysfunction, a condition where the soft palate does not close properly, causing nasal-sounding speech. Partici…

This study tests a single surgery that combines sinus endoscopy with oral surgery to treat sinusitis caused by dental issues. 36 adults who haven't improved with standard dental or medical care will receive this procedure. The goal is to see if this combined approach works better…

This study tests a drug called tocilizumab, already used for arthritis, in children and young adults with a rare brain tumor called adamantinomatous craniopharyngioma that has come back or is growing. The goal is to see if the drug can shrink the tumor or stop it from growing. Ab…

This study is testing a drug called Tovorafenib for children and young adults with craniopharyngioma, a rare, non-cancerous brain tumor that can cause serious health problems. The drug is taken by mouth and works by blocking a protein that helps the tumor grow. The trial aims to …

This study tests an oral drug called MEKTOVI (binimetinib) in children and young adults with a rare brain tumor called adamantinomatous craniopharyngioma. The goal is to see if the drug can shrink or control the tumor in patients whose tumor has come back after treatment. About 3…

This study compares two bone grafting techniques for people with cleft lip and palate. One method uses a lab-made bone material, while the other uses the patient's own hip bone. The goal is to see which approach is more cost-effective, causes less pain, and heals just as well. Ab…

This study tests a modified surgery for removing part of the upper jaw in people with tumors. Instead of complex reconstruction, surgeons preserve the sinus membrane to see if new bone grows naturally. The goal is to improve chewing, swallowing, and speech while reducing complica…

This study tests the safety and effectiveness of anlotinib, a drug that blocks blood vessel growth, in 57 adults whose craniopharyngioma has come back after surgery. The main goal is to see if the drug shrinks the tumor. Researchers will also track how long the tumor stays contro…

This study tests a new 3D printed aligner for infants born with a complete cleft lip and palate. The device aims to make nasoalveolar molding (a treatment that reshapes the gums and nose before surgery) more accurate and easier to use. Twenty infants under 45 days old will receiv…

This phase 3 trial compares proton beam therapy to standard photon radiotherapy in 156 adults with primary brain tumors. The goal is to see if proton therapy, which delivers less radiation to healthy brain tissue, improves functional survival—meaning living longer without tumor r…

Radiation for head and neck cancer can sometimes cause a serious side effect: dead bone in the jaw (osteoradionecrosis). This pilot study tests whether adding a drug cocktail called PENTOCLO to standard hyperbaric oxygen therapy helps more than oxygen alone. Twenty-four adults wi…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study is testing a new radioactive tracer called 68Ga-MY6349 to see if it can help diagnose craniopharyngioma, a rare brain tumor, using PET/CT scans. The tracer targets a protein called Trop-2, which is often found on these tumors. Twenty participants with suspected or conf…

This study tests whether giving a numbing medicine (bupivacaine) as a mist before surgery can lower pain and the need for extra painkillers in children aged 1-7 having cleft palate repair. Half the children get the mist, half get a placebo, and neither the doctors nor families kn…

This study tests whether a quadratus lumborum block—a type of nerve block—can better control pain and reduce opioid use in children aged 6 to 18 who are having palate repair surgery with bone taken from the hip. Half of the participants receive the nerve block, while the other ha…

This trial tests a new anti-fog suction device that keeps the camera lens clear during nose-to-pituitary tumor surgery. Twenty adults with pituitary or craniopharyngioma tumors will either get the device or the usual water-squirt method. The goal is to see if the device reduces f…

This Phase 3 trial tests whether metformin, a widely used diabetes drug, can improve memory and thinking in children and teens who have finished treatment for a brain tumor. About 140 participants aged 7 to 21 will take metformin or a placebo for 16 weeks. Researchers will measur…

This study tests whether an opioid-free anesthesia approach using ketamine and dexmedetomidine can control pain and reduce agitation just as well as standard opioid anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. Researchers will measure …

This study tests whether custom 3D-printed oral stents can reduce mouth sores in head and neck cancer patients receiving radiation therapy. The stents are made from a mold of the patient's mouth and cover teeth and gums during treatment. Researchers will compare sore rates and pa…

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

This study tests whether using a navigation system during balloon sinus dilation improves success rates for people with chronic maxillary sinusitis. Fifty adults who have not had prior sinus surgery will be randomly assigned to receive either standard balloon dilation or navigati…

This study tests whether adding a pain medicine called Ketorolac to standard care helps children drink more fluids after cleft palate surgery. About 74 children with cleft palate (with or without cleft lip) will take part. The goal is to see if better pain control leads to improv…

This study compares three different sedatives (ketamine, nalbuphine, and dexmedetomidine) given to 60 children aged 6 months to 3 years who need stitches removed after cleft lip or palate surgery. The goal is to see which drug works fastest and safest to keep the child calm and c…

This study tests whether a custom 3D-printed mouth splint can help burn patients who have developed microstomia (a tight, small mouth opening). Ten participants will use the splint and be measured for changes in mouth size and function using a special survey. The goal is to ease …

This study looks back at medical records of 150 children who had cleft palate surgery. Some received standard pain relief with morphine, while others also got a maxillary nerve block. Researchers want to see if the nerve block group needed less morphine, had fewer side effects, a…

This study tests a custom 3D-printed silicone tray that covers the cleft during intubation (placing a breathing tube) in children with cleft lip and palate. The goal is to reduce injuries like bleeding or swelling and make the procedure safer. About 120 children will take part, a…

This study compares two ways to sedate children before cleft palate repair: a combination of two drugs (dexmedetomidine and ketamine) given through a nebulizer versus dexmedetomidine alone. The goal is to see which approach works better for calming the child before surgery and pr…

This study aims to uncover the genetic causes of pituitary and hypothalamic tumors in children. Researchers will collect blood and tumor samples from up to 2,000 participants to analyze DNA and look for inherited patterns. The study also trains doctors and tests new MRI technique…

This study investigates how children with cleft palate, their parents, and speech-language pathologists perceive high-intensity versus low-intensity speech therapy. High-intensity therapy involves five 30-minute sessions per week over two 2-week periods, while low-intensity thera…

This study investigates why some children still have speech problems (velopharyngeal insufficiency) after cleft palate surgery. Researchers will use real-time MRI to look at how the soft palate moves and its muscle structure in children aged 7 to 12. By comparing children with di…

This study aims to find genetic factors that may cause cleft lip and palate. Researchers will analyze the DNA of 30 people with the condition using advanced sequencing. The goal is to better understand the genetic roots of this birth defect, which could inform future research.

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study aims to find genetic changes that cause orofacial clefts (like cleft lip and palate) but are missed by standard tests. Researchers will use a new, high-resolution DNA mapping method called optical genome mapping on 26 people with clefts who have no known genetic diagno…

This study observes 200 adults with head and neck cancer who need facial reconstruction using a free bone flap after surgery. Researchers will track their medical visits, treatments, and costs over time using national health data. The goal is to describe typical care pathways and…