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Your gut bacteria might predict brain radiation injury risk

NCT ID NCT07767981

Knowledge-focused Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 19, 2026 · Updated 2 times

Summary

This study looks at whether the bacteria in your gut can help predict who might experience side effects from stereotactic radiosurgery (SRS), a precise type of radiation used to treat brain tumors. Researchers will collect stool and blood samples from 150 patients before and after their standard SRS treatment, and track their recovery over time. By comparing the gut microbiome and metabolic profiles of patients who develop radiation injury versus those who don't, the study aims to uncover biological clues that could improve risk prediction and guide future care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Observational study with no intervention; examines gut microbiome and metabolites
What this could lead to
If successful, this could lead to a simple stool or blood test to predict which patients are at higher risk for radiation-induced brain injury, enabling personalized monitoring and preventive strategies.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to all patients or treatment settings, and the microbiome is highly variable, making it challenging to identify reliable signatures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients receiving stereotactic radiosurgery at the University of Chicago Medical Center as part of standard clinical care for their presumed diagnosis. Participants will be prospectively enrolled and followed longitudinally to evaluate changes in the gut microbiome and metabolomic profiles and their relationship with adverse effects following stereotactic radiosurgery.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Admitted to the University of Chicago Medical Center * Receiving stereotactic radiosurgery as standard of care for their presumed diagnosis * Able to provide informed consent Exclusion Criteria: * Anticipated survival of less than 6 months * Known or suspected infectious colitis within the month prior to enrollment * Rectal disease that prevents fecal sampling * Foreseeable inability to complete the study

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Conditions

The condition(s) this trial relates to.

radiation injury toxic encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adverse radiation effects Radiation necrosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Chicago

    RECRUITING

    Chicago, Illinois, 60637, United States

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