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Could a blood pressure cuff save organs during heart surgery?

NCT ID NCT07383909

Disease control Sponsor: Fujian Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times

Summary

This study tests a technique called remote ischemic preconditioning (RIPC) during emergency surgery for a life-threatening aortic tear. RIPC involves briefly inflating a blood pressure cuff on the arm and thigh to temporarily restrict blood flow, which may help protect the heart, brain, and kidneys from damage during surgery. The trial will compare 1,296 patients who receive RIPC to those who receive a sham procedure, tracking complications for up to 5 years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote ischemic preconditioning (RIPC) procedure
What this could lead to
If it works, this simple, non-invasive procedure could reduce serious complications like heart, brain, or kidney damage after emergency aortic surgery.
What could go wrong
This is a large trial, but the procedure is still experimental. It may not reduce complications, and there is always a risk of unforeseen issues during emergency surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,312 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years; 2. Acute type A aortic dissection requiring emergency surgery within 14 days of symptom onset; 3. Written informed consent provided by the participant or a legally authorized representative; 4. Willingness to comply with study follow-up. Exclusion Criteria: 1. Traumatic or iatrogenic aortic dissection; 2. Previous open cardiac or thoracic aortic surgery; 3. Persistent deep coma (Glasgow Coma Scale score ≤8), abdominal compartment syndrome, preoperative mechanical circulatory support, or norepinephrine-equivalent dose \>0.1 μg/kg/min; 4. Estimated glomerular filtration rate \<30 mL/min/1.73 m², total bilirubin \>342 μmol/L, or international normalized ratio \>2.0; 5. Evidence of ischemia in the limb planned for intervention, including decreased skin temperature, pain, or pallor, with or without sensory disturbance, paralysis, or diminished or absent peripheral pulses; severe deformity of the limb; or a history of arterial or venous surgery at the planned intervention site; 6. Peripheral arterial disease involving the limbs, Raynaud phenomenon, active phlebitis, or a history of lower-extremity deep vein thrombosis; 7. Current use of sulfonylureas or nicorandil; 8. Expected survival \<1 year; 9. Concurrent participation in another clinical trial that has not yet reached its primary endpoint; 10. Pregnancy or breastfeeding; 11. Immunodeficiency, a known bleeding or coagulation disorder, sickle cell anemia, or active or uncontrolled infection; 12. Any other condition considered unsuitable for enrollment by the investigator

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Conditions

The condition(s) this trial relates to.

ischemia reperfusion injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic dissection type A

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    16 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fujian Medical University Union Hospital

    RECRUITING

    Fuzhou, Fujian, 350001, China

  • Henan Provincial Chest Hospital

    NOT_YET_RECRUITING

    Zhengzhou, Henan, China

  • Qilu Hospital of Shandong University

    NOT_YET_RECRUITING

    Jinan, Shandong, China

  • Renji Hospital

    NOT_YET_RECRUITING

    Shanghai, China

  • Shengjing Hospital of China Medical University

    NOT_YET_RECRUITING

    Shenyang, Liaoning, China

  • The First Affiliated Hospital of Anhui Medical University

    NOT_YET_RECRUITING

    Hefei, Anhui, China

  • The First Affiliated Hospital of Dalian Medical University

    RECRUITING

    Dalian, Liaoning, China

  • The First Affiliated Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Harbin, Heilongjian, China

  • The First Affiliated Hospital of Sun Yat-Sen University

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, China

  • The First Affiliated Hospital of Xi'an Jiaotong University

    NOT_YET_RECRUITING

    Xi’an, Shanxi, China

  • The First Affiliated Hospital of Xiamen University

    NOT_YET_RECRUITING

    Xiamen, Fujian, China

  • The Fourth Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Harbin, Heilongjian, China

  • The Second Affiliated Hospital of AMU

    NOT_YET_RECRUITING

    Chongqing, China

  • The Second Xiangya Hospital of Central South University

    NOT_YET_RECRUITING

    Changsha, Hunan, China

  • Xiamen Cardiovascular Hospital, Xiamen University

    RECRUITING

    Xiamen, Fujian, China

  • Yan'an Hospital of Kunming City

    NOT_YET_RECRUITING

    Kunming, Yunnan, China

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