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New surgery may save more lives from deadly aortic tear

NCT ID NCT06676371

Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical methods for acute Type A aortic dissection, a life-threatening tear in the main artery. One method is the standard hemiarch replacement, and the other is a more complex total arch replacement with a frozen elephant trunk device. Researchers will enroll 150 adults in Hong Kong to see which approach leads to better 30-day survival. The goal is to find the best way to treat this emergency and reduce deaths.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical procedure (total arch replacement with frozen elephant trunk or conventional hemiarch replacement)
What this could lead to
If it works, this could establish a better surgical approach for a life-threatening aortic tear, potentially lowering the risk of death within 30 days.
What could go wrong
This is an early-stage randomized trial with 150 participants, so results may not apply to all patients. Both surgeries are complex and carry risks like bleeding, stroke, or organ failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient 's age is between 18 and 80 years. 2. Patient is willing and able to give informed consent. 3. Patient has acute type A aortic dissection with entry tear beyond ascending aorta. 4. Patient not in coma/irreversible end organ failure/cardiac massage for resuscitation Exclusion Criteria: 1. There is no identifiable entry tear in the aorta 2. The ascending entry tear extends into aortic arch 3. Patient has entry tear only in ascending aorta 4. Patient with Type B aortic dissection 5. Patient has co-morbidity (i.e. active malignancy (progressive, stable or partial remission)) causing expected survival to be less than 2 years. 6. Patient has any other medical, social, or psychological problems, that in the opinion of the investigator, preclude the patient from participating in this study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic dissection type A

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Prince of Wales Hospital

    Hong Kong, Hong Kong

  • Siriraj Hospital - Mahidol University

    Bangkok, Thailand

  • University Hospital Vienna

    Vienna, Austria

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