Simple chest squeeze may replace High-Tech ventilator settings

NCT ID NCT07623590

Knowledge-focused Sponsor: Centre Hospitalier Saint Joseph Saint Luc de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a simple manual chest compression technique works as well as electrical impedance tomography (a special imaging method) to find the best ventilator pressure for people with acute respiratory distress syndrome (ARDS). Thirty adults on ventilators will have both methods tested in random order. Researchers will compare the pressure settings and lung collapse percentages from each method over 28 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this could show that a simple manual technique works as well as advanced imaging for setting ventilator pressure in ARDS patients.
What could go wrong: This is a small, early-stage study with only 30 participants, so results may not apply to all ARDS patients. The manual method may not be as accurate as expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Moderate to severe ARDS according to the Berlin criteria * Patient receiving sedation and continuous curarization * Free and informed consent from the patient or their loved one Exclusion Criteria: * ECMO * Pneumothorax * Chest trauma in the last 3 months * Uncontrolled shock (noradrenaline \> 5 mg/h) * Pregnant or breastfeeding woman * Protected adult within the meaning of the law * Lack of social security * Patient under AME

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS (acute respiratory distress syndrome)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Simple chest squeeze may replace High-Tech ventilator settings

What the study statuses mean