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Which strengthening exercise best fixes wobbly ankles? new study aims to find out

NCT ID NCT07606534

Symptom relief Sponsor: University of Liege Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether strengthening the ankle, the hip, or both together works best for people with chronic ankle instability. 45 participants aged 18-35 will do isometric exercises three times a week for four weeks. Researchers will measure improvements in stability, strength, and balance to find the most effective approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
isometric strengthening exercises (ankle, hip, or combined)
What this could lead to
If successful, this could help clinicians choose the most effective strengthening program to improve ankle stability and reduce the risk of future sprains in people with chronic ankle instability.
What could go wrong
This is a small, early-stage trial with only 45 participants, so results may not apply to everyone. The exercises are isometric and may not fully reflect real-world movement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a history of at least one major ankle sprain that occurred at least 12 months prior to enrolment in the study, was associated with inflammatory symptoms (pain, swelling, etc), created at least one interrupted day of desired physical activity. * Have had at least two episodes of feeling like an "unstable" ankle in the six months preceding the study. * The Cumberland Ankle Instability Tool (CAIT) with a score of less than 24. * The Foot and Ankle Ability Measure (FAAM) Sport scale with a score below 80%. * Between 18 and 35 years old * Must be able to understand the study procedures and provide written informed consent Exclusion Criteria: * Have had a recent injury of less than three months prior to enrolment in the study. * A history of surgery on the musculoskeletal structures of the lower limbs. * Have a history of fracture of one of the lower limbs requiring realignment. * Being diagnosed with a neuromuscular disease. * The appearance of swelling or pain in the lower limb during the experiment.

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Conditions

The condition(s) this trial relates to.

ankle injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle sprain Chronic ankle instability, cai

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Liege

    RECRUITING

    Liège, 4000, Belgium

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