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Ventilator pressure showdown: which setting saves lungs best?

NCT ID NCT07188038

Knowledge-focused Sponsor: Vastra Gotaland Region Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 03, 2026 · Updated 2 times

Summary

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short periods. Researchers will measure diaphragm activity, breathing effort, and lung mechanics using special catheters and ultrasound.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors choose the best ventilator settings to protect the lungs and diaphragm in critically ill patients.
What could go wrong
This is a small, early-stage study with only 25 participants, so results may not apply to all patients. It measures short-term effects, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Mechanical ventilation with pressure support or mechanical ventilation with possibility to transition to pressure support * Oxygen requirement ≤ 50% * Pressure support ≤ 12 cmH2O * PEEP ≤ 12 cmH2O * Age ≥ 18 years * Adequate intravascular volume status Exclusion Criteria: * Circulatory instability * Brain death diagnosis/brain death evaluation * Norepinephrine dose \> 0.4 µg/kg/min * Muscle relaxation administered within 2 hours * Pregnancy * Contraindication to esophageal catheterization (e.g., esophageal varices) * Conditions with increased risk of pneumothorax (such as severe COPD (Chronic Obstructive Pulmonary Disease) or extensive emphysema) * Untreated pneumothorax * Symptomatic airway obstruction Discontinuation criteria during ongoing study intervention: * Heart rate \> 120 beats/min * Systolic blood pressure \> 180 mmHg * Inspired oxygen fraction \> 70% * Respiratory rate \> 35/min * RASS (Richmond Agitation Sedation Scale) ≥ 2 * Doubling of norepinephrine dose or increase of norepinephrine dose to \> 0.5 µg/kg/min to maintain mean arterial pressure * Bradycardia \< 45 beats/min

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory distress syndrome pneumonia respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS (acute respiratory distress syndrome) Pneumonia Respiratory failure Respiratory insufficiency

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Central intensivvårdsavdelning, Sahlgrenska University Hospital

    RECRUITING

    Gothenburg, Västra Götaland County, 413 45, Sweden

  • Thorax intensivvårdsavdelning, Område 6, Sahlgrenska University Hospital, Västra Götalandsregionen

    NOT_YET_RECRUITING

    Gothenburg, Västra Götaland County, 413 45, Sweden

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