Can a simple antibiotic shot stop open fracture infections?
NCT ID NCT04964947
First seen May 18, 2026 · Last updated Jun 23, 2026 · Updated 5 times
Summary
This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics to work well. The study enrolls 600 adults with open fractures of the arm or leg and will track infections for one year.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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University of Kentucky
Lexington, Kentucky, 40536, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tobramycin injection
What this could lead to
If it works, this could provide a simple, low-cost way to prevent serious infections after open fractures, reducing the need for repeat surgeries.
What could go wrong
This is a single trial with 600 participants, so results may not apply to everyone. Tobramycin can cause allergic reactions or kidney issues, and the added benefit over standard care may be small.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.