SURGICAL SITE INFECTION

This study tests whether using chlorhexidine (an antiseptic) to flush the surgical area during colorectal cancer surgery works better than using saline (salt water) to prevent infections and other complications. About 532 adults aged 18-85 with operable colorectal cancer will tak…

This study compares two types of stitches used to close wounds after abdominal surgery: one coated with an antibacterial substance and a standard uncoated one. About 3,000 adults having emergency or planned abdominal surgery will take part. The goal is to see if the coated stitch…

This study tests whether a vacuum-sealed dressing (negative pressure wound therapy) can reduce wound complications like infection or reopening after emergency abdominal surgery. About 720 adults with a large midline incision will be randomly assigned to get either the vacuum dres…

This study tests whether washing the wound and abdominal cavity with a diluted iodine solution during emergency abdominal surgery reduces the risk of surgical site infections compared to using saline. About 1,100 adults aged 18 to 80 with certain types of wounds will take part. T…

This study compares giving antibiotics only during heart surgery versus continuing them for 24 or 48 hours after, to see if shorter use prevents surgical site infections just as well. About 9,180 adults having heart surgery through the breastbone will take part. The goal is to re…

This study tests if giving antibiotics through a vein or using stitches coated with antimicrobial medicine can prevent surgical site infections in children having open groin surgery for hernias or hydroceles. About 174 children will be randomly assigned to receive one of these tr…

This study tests whether giving an extra dose of the antibiotic gentamicin directly into the surgical wound during a planned C-section can lower the chance of infection. About 100 women will take part, with half getting the extra antibiotic and half receiving standard care. Resea…

This study tests a new, gentle treatment called cold atmospheric plasma (CAP) for wounds where tubes enter the body in patients on life support. These wounds often heal slowly and get infected. The study will compare standard care alone to standard care plus CAP in 65 adults. The…

This study looks at whether showering with surgical drains in place after breast reduction or tummy tuck surgery increases the chance of infection or other complications. About 100 adults will be randomly assigned to either shower or not shower while they have drains. The goal is…